What Are the Most Common Sulfamethoxazole Side Effects?

Compound sulfamethoxazole injections are compound preparations, each containing the active ingredients sulfamethoxazole 0.4g and trimethoprim 0.08g.

Compound Sulfamethoxazole Injection

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Compound sulfamethoxazole injections are compound preparations, each containing the active ingredient sulfamethoxazole 0.4g and

Drug Name: Compound Sulfamethoxazole Injection

English name: Paediatric Compound Sulfamethoxazole Tablets

This product is a compound preparation, each containing the active ingredient sulfamethoxazole 0.4g and

This product is a white tablet.

In recent years, many clinical common pathogenic bacteria often show resistance to this product. Therefore, treatment of bacterial infections requires reference to drug sensitivity results. The main indication of this product is the following infections caused by sensitive strains.

(1) Escherichia coli, g

Common pediatric infants under 2 months are disabled. For the treatment of bacterial infections, infants over 2 months and weighing less than 40kg take SMZ 20-30mg / kg and TMP 4-6mg / kg once every 12 hours; children weighing 40kg

Prone to crystallized urine,

Tablet: containing SMZ 0.4g, TMP 0.08g; injection: 2ml (containing SMZ 0.4g, TMP 0.08g).

Compound Xinnuoming (complex tablet made of sulfamethoxazole and trimethoprim, of which sulfamethoxazole belongs to the middle-effect sulfamethoxazole and trimethoprim belongs to the sulfa synergist, the general formula is 5: 1, the Not only has the formula been reduced

Also in vitro

SMZ and TMP in this product have been

(1) Allergic reactions are more common and can manifest as

(1) Disable allergic to SMZ and TMP;

(2) Aggravated because this product prevents the metabolism of folic acid

Since this product can compete with bilirubin

(1) Combination of urinary alkalizing drugs can increase the solubility of this product in alkaline urine and increase excretion.

(2) Cannot be combined with para-aminobenzoic acid. Para-aminobenzoic acid can be taken up by bacteria instead of this product. The two antagonize each other.

(3) When the following drugs are used together with this product, this product can replace the protein binding site of these drugs, or inhibit their metabolism, so that the drug action time is prolonged or a toxic reaction occurs. Therefore, when these drugs are used simultaneously with this product, or in the application This product needs to be adjusted for subsequent use. Such drugs include oral anticoagulants, oral hypoglycemic agents, methotrexate, phenytoin, and thiopental.

(4) Combination with bone marrow suppressants may enhance the effect of such drugs

The blood concentration of this product should not exceed 200 g / ml. If this concentration is exceeded, the incidence of adverse reactions will increase and the toxicity will increase.

Excessive short-term use of this product will cause loss of appetite, abdominal pain, nausea, vomiting, dizziness, headache, drowsiness, unconsciousness, depression, fever, hematuria, crystal urine, blood disease, jaundice, bone marrow suppression, etc. General treatment is given after discontinuation

I am an unfortunate child and I feel that I cannot support it anymore ... "All relatives and medical staff are unwilling to believe that such a heavy word was spoken by a 6-year-old child. Yesterday morning, in the intensive care unit of the children's hospital Rosen (a pseudonym), who was issued two critical notices, had to rely on tracheal intubation and waited for a life-saving medicinecompound sulfamethoxazole injection.

Another child who was on the verge of lack of medicine! The cheap and old medicine compound sulfamethoxazole injection for this clinical shortage is actually the compound Xin Nuo Ming, a special effect drug that was commonly used in clinical practice more than a decade ago.

At 10 am on the 20th, when Rosen's family learned that the doctor urgently needed a compound sulfamethoxazole to rescue Rosen, everyone in the family quickly went to Shanghai's major drug stores and hospitals to find the medicine. However, including the Director of the Pharmacy Department of the Children's Hospital, all those who sought medicine that day were disappointed.

Because the compound sulfamethoxazole has only an average of more than 2 yuan, the low price makes the company unprofitable, the manufacturers have stopped production, and the old medicine is not available on the Shanghai market.

Doctors know that although there are many alternatives to this medicine, for Rosen, at the critical juncture of secondary infection with Pneumocystis carinii in the middle of leukemia chemotherapy, the alternative medicine of compound sulfamethoxazole cannot reach the drug. The best treatment effect. In fact, the day that Rosen began to have a fever, the doctor had already given him top antibiotics, but the results were not satisfactory.

Niu Jun, the secretary of the Youth League Committee of the Children's Hospital, learned that the medical staff and the family members of the children were looking for life-saving medicine, and thought of the Sunshine Loving Youth Volunteer website of the hospital, which not only has more than 2,000 registrations on the theme of college students and white-collar workers. Volunteers and more than 200 volunteers who have undergone professional training, understand leukemia-related knowledge, and regularly visit hospitals.

On the 21st, the drug-seeking post appeared on the website.

24 hours have passed. Yesterday morning, when Niu Jun rushed to the ward to understand Rosen's condition, the website volunteer Lele also rushed from the school to the hospital. This post on the website has attracted the attention of numerous volunteers and netizens.

Lele is one of the volunteers and one of more than 200 trained volunteers who care for children with leukemia. She told the Shanghai Oriental Morning Post reporter that many volunteers have reposted this drug-seeking post on major websites, and even volunteers have provided phone numbers for manufacturers of compound sulfamethoxazole produced throughout the country.

However, less time is left for Rosen Jr. At the same time that everyone was trying to find medicine for him, the hospital had to issue the first critical illness notice. The doctor told Rosen's family that if the medicine could not be found on the 22nd, the child might really have to leave.

Although the medical staff got the compound sulfamethoxazole tablets the day before, for the children who are already on the verge of danger, the little relief effect obtained by the tablets cannot replace the injections, and the pace of finding injections cannot stop.

Rosen's little aunt stood in the door of the intensive care unit and burst into tears several times. She did not want to recall the scene where a smart child chatted with her on QQ. "Although he is only 6 years old, he has received leukemia for more than two years Treatment, the good news of bone marrow aspiration in September has given us hope for success ... "

The sudden death notice also made Rosen's mother lie on Rosen's cot in the ward, crying speechlessly.

Yesterday at 3 pm, the volunteers finally got the news. In June of this year, the family of a child with the same condition as Rosen who was treated at Xinhua Hospital had found the compound sulfamethoxazole in Xinghua, Jiangsu!

After getting in touch with the patient's family members, everyone couldn't wait to call Xinghua's local Chinese medicine company, but the reality once again gave everyone a "big shot", and the local company did not have the medicine at present. However, after many petitions, the company's person in charge promised to find a way to look for it from the subordinate drug store.

At 3:30 in the afternoon, the exciting news finally reached Rosen's mother's ear. "The compound sulfamethoxazole was found!" The Rosen family who got the exact information of the drug sales location quickly drove to a local drug store in Xinghua. Pick up. Because Lu Yuan was not familiar with the traffic conditions, the local drug store promised that Rosen's family would stay in the store and wait for them after work at 5 o'clock. Everyone estimates that if nothing unexpected happens, Rosen's family will be able to rush to the pharmacy to get life-saving pills around 7 o'clock.

Deadline message

At the time of writing last night, the reporter was informed that Rosen had injected the compound sulfamethoxazole injection around 10 o'clock last night. Volunteers also let go. But does the medicine found guarantee a two-week dose for Rosen Jr.? How much stock is there in the local pharmacy? Shanghai Oriental Morning Post reporters will continue to pay attention.