What Are the Most Common Terbinafine Side Effects?

Terbinafine hydrochloride is a kind of acrylamine drug with broad-spectrum antifungal activity. This product can specifically interfere with the early biosynthesis of fungal sterols, highly selectively inhibit fungal squalene epoxidase, and block the ergot squalene epoxidation reaction during the formation of fungal cell membranes, thereby achieving killing or inhibiting fungi Role.

Terbinafine

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Terbinafine hydrochloride is a kind of acrylamine drug with broad-spectrum antifungal activity. This product can specifically interfere with the early biosynthesis of fungal sterols, highly selectively inhibit fungal squalene epoxidase, and block the ergot squalene epoxidation reaction during the formation of fungal cell membranes, thereby achieving killing or inhibiting fungi Role.

Drug Name

Terbinafine

Alias

Terbinafine Hydrochloride Tablets

Origin

: Sichuan Aobang Pharmaceutical Co., Ltd.

Storage

: Sealed and stored in a cool and dry place

Chemical name: (E) -N- (6,6-dimethyl-2-hepten-4-ynyl) -N-methyl-1-formamide naphthalene · terbinafine hydrochloride tablets

English name: Terbinafine Hydrochloride Tablets

Ingredients: The main ingredient of this product is Terbinafine Hydrochloride. This product is a white tablet.

Contraindications: Those who are allergic to terbinafine hydrochloride and other ingredients of this product are contraindicated.

Storage: sealed and stored in a cool and dry place.

Validity period: two years.

Specifications: 0.25g * 6 tablets / box.

Place of Origin: Sichuan Aobang Pharmaceutical Co., Ltd.

This product is suitable for:

1. Skin caused by Trichophyton rubrum (Trichophyton rubrum, Trichophyton versicolor, Trichophyton verrucosa, Trichophyton versicolor, Trichophyton purpura, etc.), Microsporum canis, Epidermophyton floccus , Hair and nail infections.

2. A variety of ringworm diseases (tinea corporis, jock itch, tinea pedis, tinea capitis, etc.) and yeast infections of the skin caused by Candida (Candida albicans, etc.).

3. Onychomycosis (onychomycosis) caused by mold. Absorption, distribution, elimination: According to the literature, a single oral administration of terbinafine 250mg, the peak plasma concentration within 2 hours after the drug reached 0.97 g / ml. The absorption half-life of this product is 0.8 hours and the distribution half-life is 4.6 hours. Its bioavailability is slightly affected by eating, but it is not necessary to adjust the dose. The drug-plasma protein binding rate is 99%, and it can quickly diffuse through the dermis and concentrate in the lipophilic stratum corneum. Terbinafine can also be secreted into the skin, so it can reach quite high concentrations in hair follicles, hair and sebum-prone skin. In the first few weeks of treatment, terbinafine can be on the deck. Biotransformed metabolites of this product have no antifungal activity and they are mainly excreted from the urine. Its elimination half-life is 17 hours and has no accumulation in the body. its

Oral, 0.25 grams each time for adults, once a day, the course of treatment is as follows: The course of skin infections: tinea pedis [toe (finger) type and palate type]: 2 to 6 weeks; ringworm, jock itch: 2 to 4 weeks;

This product is well tolerated with mild to moderate side effects and is often transient. The most common are gastrointestinal symptoms (fullness, loss of appetite, nausea, mild abdominal pain and diarrhea) or mild skin reactions (rash, urticaria, etc.). Individual cases of severe skin reactions (such as Stevens-Johnson Syndrome,

[Indications]

1. Skin caused by Trichophyton rubrum (Trichophyton rubrum, Trichophyton versicolor, Trichophyton verrucosa, Trichophyton versicolor, Trichophyton purple, etc.), Microsporum canis and Epidermophyton flocculent , Hair and nail infections.

2. A variety of ringworm diseases (tinea corporis, jock itch,

1. For patients with liver or kidney dysfunction (heparin clearance <50ml / min, serum creatinine> 300u mol / L), the terbinafine dose should be reduced by 50% (see "Adverse Reactions"). This product should be kept out of the reach of children.

2. Studies on pregnancy and mammals have shown that this product has no adverse effects on the fetus and fertility. Because this product has very limited experience in pregnant women. Therefore, the pros and cons should be weighed, and in principle pregnant women should not use it. Terbinafine can be excreted through milk, so mothers receiving oral treatment with terbinafine should not breastfeed.

3. Interaction studies have shown that terbinafine has little effect on the clearance of drugs metabolized by the cytochrome P450 enzyme system (such as cyclosporine, D860 or oral contraceptives). However, women using oral contraceptives should use this product with caution as very few people may have menstrual disorders. In addition, liver drug enzyme-inducing drugs (such as rifampicin) can speed up the plasma clearance of terbinafine, and liver drug enzyme inhibitors (such as cimetidine) can inhibit its clearance. The dose of terbinafine needs to be adjusted appropriately.

4 This product is not effective on tinea versicolor.

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