What Are the Pros and Cons of Taking Amoxicillin?

Amoxicillin capsule, the indication is that amoxicillin is suitable for the following infections caused by sensitive bacteria (strains that do not produce -lactamase): 1. otitis media caused by Streptococcus hemolyticus, Streptococcus pneumoniae, Staphylococcus or Haemophilus influenza , Sinusitis, pharyngitis, tonsillitis and other upper respiratory tract infections. 2. Urogenital infections caused by Escherichia coli, Proteus mirabilis or Enterococcus faecalis. 3. Skin and soft tissue infections caused by hemolytic streptococcus, staphylococcus, or Escherichia coli. 4. Acute bronchitis, pneumonia and other lower respiratory tract infections caused by hemolytic streptococcus, pneumococcus, staphylococcus, or haemophilus influenzae. 5. Acute simple gonorrhea. 6. This product can still be used to treat typhoid, typhoid carriers and leptospirosis; Amoxicillin can also be combined with clarithromycin and lansoprazole to eradicate stomach and duodenal Helicobacter pylori and reduce peptic ulcer Recurrence rate.

Amoxicillin capsule, the indication is that amoxicillin is suitable for the following infections caused by sensitive bacteria (strains that do not produce -lactamase): 1. otitis media caused by Streptococcus hemolyticus, Streptococcus pneumoniae, Staphylococcus or Haemophilus influenzae , Sinusitis, pharyngitis, tonsillitis and other upper respiratory tract infections. 2. Urogenital infections caused by Escherichia coli, Proteus mirabilis or Enterococcus faecalis. 3. Skin and soft tissue infections caused by hemolytic streptococcus, staphylococcus, or Escherichia coli. 4. Acute bronchitis, pneumonia and other lower respiratory tract infections caused by hemolytic streptococcus, pneumococcus, staphylococcus, or haemophilus influenzae. 5. Acute simple gonorrhea. 6. This product can still be used to treat typhoid, typhoid carriers and leptospirosis; Amoxicillin can also be combined with clarithromycin and lansoprazole to eradicate stomach and duodenal Helicobacter pylori and reduce peptic ulcer Recurrence rate.

Drug Name

Amoxicillin capsule

Drug type

Prescription medicines, essential medicines, medicines for medical workers' injuries

Use classification

Antibiotics

Amoxicillin capsule ingredients

Chemical name: (2S, 5R, 6R) -3,3-dimethyl-6-[(R)-()-2-amino-2- (4-hydroxyphenyl) acetylamino] -7-oxygen Substituted-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid trihydrate.
Chemical Structure:

Molecular formula: C ₁₆ H ₁₉ N ₃ O ₅ S · 3H ₂ O
Molecular weight: 419.46

Amoxicillin capsule properties

This product is a capsule and the content is white or off-white powder.

Amoxicillin capsule indication

Amoxicillin is suitable for the following infections caused by sensitive bacteria (strains that do not produce -lactamase):
1. Upper respiratory tract infections such as otitis media, sinusitis, pharyngitis, tonsillitis caused by Streptococcus hemolyticus, Streptococcus pneumoniae, Staphylococcus or Haemophilus influenzae.
2. Urogenital infections caused by Escherichia coli, Proteus mirabilis or Enterococcus faecalis.
3. Skin and soft tissue infections caused by hemolytic streptococcus, staphylococcus, or Escherichia coli.
4. Acute bronchitis, pneumonia and other lower respiratory tract infections caused by hemolytic streptococcus, pneumococcus, staphylococcus, or haemophilus influenzae.
5. Acute simple gonorrhea.
6. This product can still be used to treat typhoid, typhoid carriers and leptospirosis; Amoxicillin can also be combined with clarithromycin and lansoprazole to eradicate stomach and duodenal Helicobacter pylori and reduce peptic ulcer Recurrence rate.

Amoxicillin capsule specifications

0.5g (calculated based on C ₁₆ H ₁₉ N ₃ O ₅ S)

Amoxicillin capsule dosage

oral. Adults 0.5g once, once every 6 to 8 hours, the daily dose does not exceed 4g.
The daily dose for children is 20 40mg / Kg every 8 hours; the daily dose for infants under 3 months is 30mg / Kg every 12 hours.
Patients with severely impaired renal function need to adjust the dosage. Patients with an endogenous creatinine clearance rate of 10 to 30 ml / min are 0.25 to 0.5 g every 12 hours; patients with endogenous creatinine clearance rate of less than 10 ml / min are 0.25 to 0.5 per 24 hours. g.

Adverse effects of amoxicillin capsules

1. Gastrointestinal reactions such as nausea, vomiting, diarrhea, and pseudomembranous enteritis.
2. Allergic reactions such as rash, drug fever and asthma.
3. Anemia, thrombocytopenia, and eosinophilia.
4. Serum aminotransferase can be slightly increased.
5. Double infection caused by Candida or resistant bacteria.
6. Occasionally, central nervous system symptoms such as excitement, anxiety, insomnia, dizziness, and abnormal behavior.

Amoxicillin capsule contraindications

Penicillin allergy and penicillin skin test positive patients are contraindicated.

Notes for amoxicillin capsules

1. Penicillin oral medications can cause anaphylactic shock. They are more common in patients with a history of penicillin or cephalosporin allergy. Before taking the drug, you must ask for a detailed history of the drug allergy and do a penicillin skin test. If anaphylactic shock occurs, local rescue should be provided to maintain airway patency, inhale oxygen, and apply treatment measures such as epinephrine and glucocorticoids.
2. Patients with infectious mononucleosis are prone to rash when using this product and should be avoided.
3. Patients with a longer course of treatment should check liver and kidney function and blood routine.
4. Amoxicillin can cause false positives in urine glucose tests using Benedict or Fehling reagents.
5. The following situations should be used with caution:
(1) People with a history of allergic diseases such as asthma and hay fever.
(2) The dosage may need to be adjusted in the elderly and severely impaired renal function.

Amoxicillin capsules for pregnant and lactating women

Animal reproduction tests showed that amoxicillin at 10 times the human dose did not damage fertility and fetuses in rats and mice. However, there is not enough controlled studies in humans. Given that animal reproduction tests cannot fully predict human response, pregnant women should only use this product when it is really necessary. Because a small amount of amoxicillin is secreted in milk, the baby can cause allergies after taking it.

Amoxicillin capsules for children

See dosage, or as directed by your doctor.

Amoxicillin capsules for elderly

See dosage, precautions, etc., or as directed by your doctor.

Amoxicillin capsule drug interactions

1. Probenecid reduces competitively the renal tubular secretion of this product, and the simultaneous application of both can lead to an increase in amoxicillin blood concentration and a prolonged half-life.
2. Chloramphenicol, macrolides, sulfa and tetracyclines interfere with the antibacterial effect of amoxicillin in vitro, but its clinical significance is unknown.

Amoxicillin capsule overdose

A prospective study involving 51 pediatric patients suggested that amoxicillin did not cause significant clinical symptoms when administered at doses not exceeding 250 mg / Kg. There have been reports of a small number of patients with renal insufficiency and oliguria caused by amoxicillin overdose, but renal function impairment is reversible after discontinuation.

Amoxicillin capsule pharmacology and toxicology

Amoxicillin is a penicillin antibiotic. It is effective against aerobic gram-positive cocci such as Streptococcus pneumoniae and hemolytic streptococcus, penicillinase-free staphylococci, enterococcus faecalis, etc. -lactamase-producing strains of H. pylori and aerobic gram-negative bacteria such as Haemophilus, Haemophilus influenzae, Neisseria gonorrhoeae, and H. pylori have good antibacterial activity. Amoxicillin exerts a bactericidal effect by inhibiting the synthesis of bacterial cell walls, which can make bacteria quickly become spherical and dissolve and rupture.

Pharmacokinetics of amoxicillin capsules

It is absorbed quickly after oral administration, and about 75% to 90% can be absorbed from the gastrointestinal tract, and the effect of food on drug absorption is not significant. After oral administration of 0.25g and 0.5g, the peak plasma concentrations (Cmax) were 3.5 to 5.0 mg / L and 5.5 to 7.5 mg / L, respectively, and the peak time was 1 to 2 hours. This product is well distributed in most tissues and body fluids. Patients with acute episodes of pneumonia or chronic bronchitis had 0.5g or 0.53mg / L and 0.53mg / L of sputum in the sputum, respectively, 2 to 3 hours and 6 hours after taking 0.5g of this product. mg / L. Children with chronic otitis media take 1 g of this product 1 to 2 hours after oral administration of this product, and the drug concentration in the middle ear fluid is 6.2 mg / L. Patients with tuberculous meningitis have a concentration of 0.1 to 1.5 mg / L in the cerebrospinal fluid 2 hours after oral administration of 1 g of this product, which is equivalent to 0.9% to 21.1% of the blood concentration in the same period. This product can pass through the placenta. The concentration in umbilical cord blood is 1/4 to 1/3 of the maternal blood concentration, and it is also traced in milk, sweat and tears. The protein binding rate of amoxicillin is 17% to 20%. The blood elimination half-life (t _1/2 ) of this product is 1 to 1.3 hours. After administration, about 24% to 33% of the administered amount is metabolized in the liver, and within 4 hours, 45% to 68% of the administered amount is self-urined with the original drug. Excreted in the middle, and some drugs were excreted through the biliary tract. Patients with severe renal insufficiency can be extended to 7 hours. Hemodialysis can remove this product, while peritoneal dialysis has no effect.

Amoxicillin capsule storage

Shaded and sealed.

Amoxicillin capsule packaging

(1) Aluminum plastic blister packaging: 0.5g / capsule, 16 capsules / small box (2) Aluminum plastic blister packaging: 0.5g / capsule, 20 capsules / small box (3) Aluminum plastic blister packaging: 0.5g / Capsules, 24 capsules / box (1) Aluminum plastic blister packaging: 0.5g / capsules, 32 capsules / box

Amoxicillin capsule expiration date

36 months.

Amoxicillin Capsules

"Chinese Pharmacopoeia" 2010 edition two ^[1]