What Are the Pros and Cons of Using Transfusions for Anemia?

Blood transfusion should master the principle of blood transfusion, strictly control the scope of blood transfusion treatment, and those who can not be treated with blood transfusion should not be transfused.

Blood transfusion treatment

Chinese name: Blood transfusion treatment

The normal human platelet count is (100-300) × 109 / L, and about 1/3 of the platelets in the circulatory system are stored in the spleen. The in vivo survival time of normal human platelets is 8 to 11 days (measured by 51Cr labeling), and the half-life period is 3.7 to 4.0 days (measured by 111In labeling).

Whole blood refers to all components of blood, including blood cells and various components in plasma. The blood is collected into a container containing an anticoagulant or a preservation solution without any processing, that is, whole blood.

China sets 200ml of whole blood as 1U (unit). Due to individual differences in blood donors and storage time, there is a "permissible" range in the content of various components in each "unit" of whole blood. The nature of whole blood mainly depends on the type of anticoagulant or preservation solution and the storage time. With the extension of storage time, the content of some active components (2,3-DPG, ATP, white blood cells, platelets, coagulation factors, etc.) in the blood decreases, and the function gradually loses, while some harmful components (blood ammonia, free hemoglobin, blood potassium) Etc.) will gradually increase, and its rate of change has a greater relationship with the type of anticoagulant or preservation solution.

Indications for blood transfusion therapy

(1) Bone marrow and organ transplantation.

(2) Patients with a history of non-hemolytic transfusion fever.

(3) Patients with a history of GVHD after transfusion.

(4) Patients with high-dose chemotherapy and radiotherapy.

When the above patients need blood transfusion, choose the blood and its components after irradiation treatment. For the indications, contraindications and precautions of various components, please refer to the corresponding content.

Purpose of irradiation for blood transfusion therapy

The blood and its components are irradiated with radiation to inactivate the lymphocytes and viruses in the blood and its components, prevent the occurrence of blood transfusion GVHD, and reduce the occurrence of blood transmissible infectious diseases.