What Are the Side Effects of Proton Pump Inhibitors?

Proton pump inhibitors (PPIs) are an important class of drugs that inhibit gastric acid secretion after H2 receptor blockers. They are also the class of drugs that have the strongest inhibitory effect on gastric acid secretion. At present, the drugs commonly used in this class are omeprazole, lansoprazole, pantoprazole, rabeprazole and esmeprazole.

Basic Information

Drug Name

Proton pump inhibitor

Foreign name

proton pump inhibitors

Whether prescription drugs

prescription

Main indications

Duodenal ulcer

Dosage form

powder

Athletes use with caution

Inadvertent use

Whether to include health insurance

Incorporate

Pharmacological effects of proton pump inhibitors

Gastric wall cells secrete acid through the H, K-ATPase on the membrane, in the manner of H to K exchange, the intracellular H is pumped out. After being absorbed into the blood, the drug diffuses into human gastric parietal cells and covalently binds to HK-ATPase to irreversibly inactivate pump molecules. Gastric acid secretion only resumes when new pump molecules are synthesized and inserted into the cell membrane. Therefore, this class of drugs has a strong and long-lasting effect of inhibiting gastric acid, and can reduce the secretion of pepsin. This class of drugs acts on the last part of gastric acid secretion, so this class of drugs can effectively inhibit the secretion of gastric acid whether or not there are other factors that stimulate gastric acid secretion. However, proton pump inhibitors are not acid-resistant and are easily degraded in acidic environments. To avoid this, oral dosage forms often use capsules, enteric tablets and other preparations to avoid the damage of gastric acid.

Application scope of proton pump inhibitor

Proton pump inhibitors can be used clinically to treat peptic ulcer, gastroesophageal reflux disease, Zhuo'ai syndrome, and upper gastrointestinal bleeding. It has become the first-line drug for abnormal gastric acid secretion and related diseases. Combined with amoxicillin, clarithromycin and other drugs to treat Helicobacter pylori infection.

Proton pump inhibitor adverse reactions

Mainly nausea, flatulence, diarrhea, constipation, epigastric pain, etc. Rashes, ALT, and bilirubin elevations also occur, and are generally mild and transient, and most do not affect treatment.

Proton pump inhibitor precautions

The safety of PPI for pregnant women and children has not been established. It is not suitable for pregnant and lactating women and children. In addition, PPI may mask the symptoms of gastric cancer. For those suspected of having malignant tumors with gastric ulcer, it must be excluded after malignant lesions. To avoid misdiagnosis. Use with caution in patients with a history of drug allergies and elderly people. Patients with liver and kidney dysfunction should be used with caution; those with severe liver dysfunction should reduce the dose and regularly measure changes in liver enzyme spectrum, limit the daily dose, and are not recommended for long-term maintenance treatment.

(Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.)