What Are the Symptoms of Trazodone Withdrawal?

Trazodone is a tetracyclic atypical antidepressant, which can selectively antagonize the reuptake of serotonin (5-HT) and has a weak effect of preventing norepinephrine (NA) reuptake. However, it has no effect on dopamine (DA), histamine, and acetylcholine, nor does it inhibit the activity of monoamine oxidase inhibitor (MAO) in the brain. In addition, this product also has an antagonistic effect on 5-HT2A receptor or 5-HT2C receptor. The 5-HT2 receptor located in the presynaptic membrane belongs to the self-receptor, and plays a negative feedback regulation effect on the release of 5-HT; this product also suppresses negative feedback regulation and increases the release of 5-HT to achieve an antidepressant effect. This product also has a central sedative effect and a slight muscle relaxation effect, but has no anti-spasmodic and central excitatory effects, can improve sleep, significantly shorten the sleep latency of patients with depression, prolong overall sleep time, and improve sleep quality.

Basic Information

Drug Name

Trazodone

Alias

Clopiper

Applicable to depression and anxiety accompanied by depression and mood disorders after withdrawal from drug dependence. Patients with intractable depression are ineffective with other antidepressants and are often effective with this product. It is especially suitable for patients with senile depression or heart disease.

Oral: Initially 50 to 100 mg / day, divided into doses, with an increase of 50 mg / day every 3 to 4 days, with a maximum amount of 400 mg / day. The long-term maintenance dose should be kept at the lowest effective dose.

Adverse reactions were few and mild. The most common adverse reactions were drowsiness with occasional skin irritation, blurred vision, constipation, dry mouth, high blood pressure or hypotension, tachycardia, dizziness, headache, abdominal pain, nausea, vomiting, muscle pain, tremor, and synergy.

Epilepsy, mild to moderate liver dysfunction, renal dysfunction, and acute recovery of myocardial infarction should be used with caution. Use with caution for pregnant and lactating women.

Gastrointestinal symptoms such as nausea, vomiting, diarrhea, and abdominal tenderness can occur after sudden withdrawal. A few patients develop hypotension and syncope after taking it. Trazodone should be taken after a meal. Fasting conditions or fasting may increase dizziness or dizziness.

It is not advisable to participate in activities that require high concentration and alertness during medication, such as driving and working at heights.

Patients who are allergic to this drug should not use it in patients with severely impaired liver function, severe heart disease, arrhythmia, and acute conscious disturbance. Not recommended for children and adolescents under 18.

Not for use with MAOIs. SSRIs such as fluoxetine and paroxetine can reduce the clearance of this product and can also cause 5-HT syndrome with it. This product inhibits the metabolism of carbamazepine and phenytoin in the liver and increases the blood concentration of the latter. This product inhibits the antihypertensive effect of central antihypertensive drugs (such as clonidine). Combined with chlorpromazine, triflurazine, perphenazine, mesodazine, thioridazine and other drugs, it can produce a synergistic hypotensive effect and cause hypotension. Combined with droperidol, it can increase the cardiotoxicity of the latter.

Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.