What Are the Uses of IV Labetalol?

Laberolol hydrochloride for injection, 1. It is suitable for treating various types of hypertension, especially hypertension crisis. It is also suitable for hypertension with coronary heart disease and hypertension with a history of angina pectoris or heart failure. 2. Suitable for controlling blood pressure before surgery 3. Suitable for hypotensive treatment of pheochromocytoma. 4. Suitable for pregnancy-induced hypertension. ^[1] .

Drug Name: Laberolol Hydrochloride for Injection
Hanyu Pinyin: Yan Suan La Bei Luo Er

Drug type: Sympathetic inhibitor
Use classification: Antihypertensive drugs

Labelol hydrochloride for injection

Main ingredients
Labelol hydrochloride Chemical name: 5- [1-hydroxy-2 (1-methyl-3 phenylpropylamino) -ethyl] salicylamide hydrochloride Molecular formula: C ₁₉ H ₂₄ N ₂ O ₃ · HCl
Molecular weight: 364.87

Labelol hydrochloride for injection

This product is white or off-white lyophilized block.

Labelol hydrochloride for injection indications

1. Suitable for treating various types of hypertension, especially hypertension crisis. It is also suitable for hypertension with coronary heart disease and hypertension with a history of angina pectoris or heart failure.
2. Suitable for controlling blood pressure before surgery 3. Suitable for hypotensive treatment of pheochromocytoma.
4. Suitable for pregnancy-induced hypertension.

Labelol hydrochloride for injection

(1) 25mg (2) 50mg

Laberolol Hydrochloride for Dosage and Administration

1. Intravenous bolus: 25 50mg at a time, plus 10% glucose injection 20ml, slowly bolus within 5-10 minutes, if the antihypertensive effect is not ideal, it can be repeated once after 15 minutes until the ideal hypotensive effect . The total dose should not exceed 200 mg, and the maximum effect usually occurs within 5 minutes after bolus injection, which is maintained for about 6 hours.
2. Intravenous drip: 100mg of this product, diluted with 5% glucose injection or 0.9% sodium chloride injection to 250ml, intravenous drip rate is 1-4mg / min, until a good effect is achieved, then stop the drip, The effective dose is 50-200 mg, but it may be more than 300 mg for patients with pheochromocytoma.

Adverse reactions of labetalol hydrochloride for injection

Patients occasionally have dizziness, gastrointestinal upset, fatigue, paresthesia, and exacerbation of asthma. Individual patients have orthostatic hypotension.

Contraindications of Labetalol Hydrochloride for Injection

1. Forbidden in patients with bronchial asthma.
2. Cardiogenic shock, cardiac block ( to degree atrioventricular block) are disabled.
3. Severe or acute heart failure, sinus bradycardia and other patients are disabled.
4. Those who are allergic to this product are prohibited.

Precautions for Labetalol Hydrochloride for Injection

1. It should be used with caution in the following cases: history of allergies, congestive heart failure, diabetes, emphysema or non-allergic bronchitis, liver insufficiency, hypothyroidism, Raynaud's syndrome or other peripheral vascular disease, and renal failure.
2. Intravenous medication should be in the supine position. Do not overspeed during infusion to prevent blood pressure from falling too fast. After injection, lie still for 10-30 minutes.

Labelol hydrochloride for injections for pregnant and lactating women

This product can be safely and effectively used in pregnancy-induced hypertension, does not affect fetal growth and development, and the concentration in milk is 22% to 45% of maternal blood, and has no side effects on lactating infants.

Labelol hydrochloride for injection drug interactions

1. Simultaneous application of this medicine and tricyclic antidepressants can cause tremor.
2. This product can reduce the reflective tachycardia of nitroglycerin, but the antihypertensive effect can be synergistic.
3. Be very cautious when used in combination with verapamil calcium antagonists.
4. This product can enhance the effect of halothane on blood pressure.