What Factors Affect a Sufficient Famotidine Dosage?

Motidine for injection, indications are upper gastrointestinal bleeding caused by peptic ulcer, and gastric and duodenal mucosal erosion and bleeding caused by various reasons other than tumors, esophagus, and varices of the gastric fundus.

Motidine for injection, indications are upper gastrointestinal bleeding caused by peptic ulcer, and gastric and duodenal mucosal erosion and bleeding caused by various reasons other than tumors, esophagus, and varices of the gastric fundus.

Drug Name

Motidine for injection

Drug type

Prescription medicines, essential medicines, medicines for medical workers' injuries

Use classification

Drugs that inhibit gastric acid secretion

Motitin Ingredients for Injection

The main ingredients of this product are: famotidine, excipients: aspartic acid, mannitol.
The chemical name of famotidine is: [1-amino-3-[[[2-[(diaminomethylene) amino] -4-thiazolyl) -methyl) thio] propylene] sulfonamide chemistry Structural formula:

Molecular formula: C ₈ H ₁₅ N ₇ O ₂ S ₃
Molecular weight: 337.45

Injection usage morphine traits

This product is white loose block or powder.

Motitin indications for injection

Upper gastrointestinal bleeding caused by peptic ulcer, and gastric and duodenal mucosal erosion and bleeding caused by various reasons other than tumors, esophagus, and varicose veins of the gastric fundus.

Motidine Specifications for Injection

20mg

Injection Motidine Usage Dosage

This product is used in patients with peptic ulcer complicated by upper gastrointestinal bleeding or gastric and duodenal mucosal erosion bleeding, which must reduce gastric acid secretion and is not suitable for oral administration. This product is intravenously infused with 20mg diluted with 250ml of 5% glucose for a period of more than 30 minutes, or a slow bolus of intravenous injection of 20ml of physiological saline (not less than 3 minutes). Twice a day (with an interval of twelve hours), the course of treatment is five days. Once the condition permits, the intravenous medication should be quickly changed to oral administration.

Motidine adverse reactions

A few patients may have dry mouth, dizziness, insomnia, constipation, diarrhea, rash, facial flushing, increased blood pressure, menstrual disorders, and decreased white blood cells. Occasionally a slight increase in transaminase and so on.

Motitin contraindications for injection

Allergic to this product, severe renal insufficiency, pregnant women, lactating women are prohibited.

Motidine precautions for injection

1. This product will conceal the symptoms of gastric cancer, so it should be administered after the tumors, esophagus, and varicose veins are excluded.
2. Patients with liver and kidney dysfunction should be used with caution.

Motidine for pregnant women and lactating women

Banned for pregnant and lactating women

Motidine for children

The safety of pediatric medication has not been established, so it is not recommended for children.

Motidine for injection

This product is mainly excreted through the kidney. Because elderly patients often have renal dysfunction, blood concentrations will accumulate, so the dose should be reduced or the interval between doses should be extended.

Injection usage motidine drug interactions

This product has been reported to have a slight effect on the pharmacokinetics of theophylline, warfarin, diazepam, and nifedipine; probenecid inhibits excretion of famotidine from the renal tubules.

Motidine overdose for injection

Excessive use (80mg / day) can cause elevated serum prolactin, breast swelling, sensitivity and swelling, and the symptoms disappear after stopping the drug.

Motidine Pharmacology and Toxicology

This product is a fluorenylthiazole H ₂ receptor blocker. It has a high affinity for H ₂ receptors. It has a significant inhibition on gastric acid secretion. Increased pepsin has an inhibitory effect. This product does not change the gastric emptying rate, does not interfere with pancreatic function, and has no adverse effects on the cardiovascular system and kidney function. This product is different from cimetidine, but has similarities with ranitidine, that is, the adverse reactions of androgen antagonism such as male breast development, impotence, lack of sexual desire and breast tenderness in women, Breast milk etc. No teratogenic, carcinogenic, inhibitory drug enzymes and androgens effects.

Pharmacokinetics of Motidine for Injection

After intravenous injection, the plasma clearance rate is (25/29) h, the renal clearance rate is 18 L / h, and t _1/2 is 3 hours. It is widely distributed in the body, with high concentrations in the digestive tract, liver, kidney, submandibular gland and pancreas, but does not penetrate the placental barrier. It is mainly excreted from the kidney (80%) as the prototype and metabolites (S-oxides), and the amount of bile excretion is small, and it can also appear in milk.

The interaction with other drugs is not obvious; however, there are reports of a slight effect on the pharmacokinetics of theophylline, warfarin, diazepam, and nifedipine. ^[1]

Motitin Storage for Injection

Shaded, sealed and stored at room temperature.

Motitin packaging for injection

Xilin bottled 1. Ordinary type: 20mg / bottle, 1 bottle (2 bottles or 10 bottles) / small box;
2. Pre-flushing type: 20mg / bottle, 5 bottles (1 bottle, 2 bottles or 10 bottles) / box, equipped with single-use prefilled injection drug dissolver (with needle).

Motidine for injection

36 months

Motitin Implementation Standards for Injection

YBH02822009