What Is a Metered-Dose Inhaler?

Inhalation, a pharmaceutical dosage form. These drugs use aerosol inhalation to treat asthma. Such as tiotropium bromide powder inhaler, budesonide powder inhaler, peppermint inhaler, cobiter atomized inhaler and so on.

Inhalant

Inhalation, a pharmaceutical dosage form. These drugs use aerosol inhalation to treat asthma. Such as tiotropium bromide powder inhaler, budesonide powder inhaler, peppermint inhaler, cobiter atomized inhaler and so on.

Chinese name

Inhalant

Foreign name

Tiotropium Bromide Powder for Inhalation

Nature

A drug

Types of

Imported drugs

Pharmaceutical ingredients

The main ingredient of this product is tiotropium bromide

Generic name

Tiotropium bromide powder inhaler

Drug specifications

18g

Drug Standard

H20050268

Tiotropium bromide powder inhaler

Phonetic name: Saituoxiuanfen Xiruji

English name: Tiotropium Bromide Powder for Inhalation

Manufacturer: Boehringer Ingelheim Pharma GmbH & Co. KG

Drug description

.

Drug properties: This product is a hard capsule for inhalation, containing white

The use of aerosol inhalation treatment is one of the effective methods for the treatment of asthma. The effect of inhalation treatment is related to the inhalation device and the correct use method. Now introduce the commonly used inhalation device and correct use method:

Pressure quantitative aerosol inhaler

Pressure quantitative aerosol inhaler Pressure quantitative aerosol inhaler is composed of three components: medicine, propellant, surface active substance or lubricant. Aerosols using this type of inhalation device include Vantorin aerosol, Chuankang aerosol, Aiquanle aerosol, Bicotonone aerosol, cositone aerosol, and Promic aerosol. Wait.

Use method is:

Remove the cover of the sleeve, and gently shake the medicine tank to mix it before use.

Exhale your head slightly and exhale slowly, exhaling the air in your lungs as much as possible.

Hold the inhaler mouthpiece tightly in your mouth, hold your breath, press the inhaler with your index finger and thumb to release the medicine, and at the same time do a slow and deep inhalation synchronized with the spray, preferably longer than 5 seconds ( Some devices have a flute sound. If you do not hear the flute sound, it means that the medicine is not inhaled).

Hold your breath for 5-10 seconds as far as possible, so that the drug is fully distributed to the lower airway to achieve a good therapeutic effect.

Put the cover back on the spout.

Rinse your mouth with water to remove any medicine left on the upper pharynx.

2. Dry powder inhaler

The dry powder inhaler disperses the drug particles through the kinetic energy of the user's active inhalation of air, and the flow rate of the dry powder mist particles is consistent with the user's inhalation flow rate. There are two types of dry powder inhalers commonly used in China: stored-dose eddy current dry powder inhalers, commonly known as Dubao, such as Primic Dubao and Oaks Dubao. The other is a quasi-injector, such as Shulidie.

How to use Dubao:

Rotate and remove the cap. Check the dose indication window to see if there is a sufficient dose of medication.

Hold Dubao in one hand, hold the bottom cover in the other hand, turn right to the bottom first, then turn left to the bottom. When you hear a "click", you can complete the filling of one dose.

Before inhaling, exhale gently (do not blow on the mouthpiece), put the mouthpiece in your mouth, and inhale deeply to complete an inhalation action. Hold your breath for about 5-10 seconds after inhaling the drug.

Close the cap tightly after use. Rinse mouth after 10 minutes.

How to use the accumulator:

Hold the susceptor case with one hand, and push the slider of the susceptor outward with the thumb of the other hand until it clicks, indicating that the susceptor is ready to take medicine.

Hold the quasi-receptor and keep it away from your mouth. Exhale as far as possible under the premise of ensuring a smooth breathing.

Put the mouthpiece into the mouth, inhale deeply and smoothly, inhale the medicine into the mouth, and hold your breath for about 10 seconds.

Take out the quasi-receiver, slowly resume exhalation, and close the quasi-receiver (closed when you hear a click).

Dry powder inhalants The main advantages of dry powder inhalants are that they do not require the use of propellants, and the stability of pre-loaded drug dry powder is good. In the past 10 years, in addition to the increasing number of powder inhalation devices, its varieties have also evolved from a single asthma treatment to antibiotics (such as tobramycin), biotechnology drugs and gene drugs, and a variety of compound powder aerosols have been marketed, such as Burkner (beclomethasone propionate) and sodium cromoglycate compound powder, salmeterol and fluticasone propionate powder and so on. Lung insulin dry powder inhalants being developed abroad include: AIR lung release products from Aventis / Lilly, AERx lung release products from Aradigm / Novo Nordisk, and insulin inhalation from Kos Pharmaceuticals Agents, Baxter's ProMaxx insulin microsphere lung inhalants, Bristol-Myers Squibb and Qdose insulin inhalers.

Necta Therapeutics / Pfizer / Aventis' insulin inhaler Exubera was approved by the US FDA in 2006, which is a revolution in non-injection administration of macromolecular drugs. Exubera is a white powder packaged in vesicles. Each single-dose package contains 1 mg or 3 mg of insulin. The prescription also contains sodium citrate, mannitol and sodium hydroxide. When in use, the vesicles are filled into the inhaler. After the button is pressed, the vesicles rupture, and the insulin fine powder is dispersed into an aerosol, which is automatically inhaled by the patient into the lungs. Lung deposition rate of 1 mg packaged insulin inhalant reaches 45%, while 3 mg packaged insulin inhaler has a lung deposition rate of 25%. Bespak has recently completed the industrial production of Exubera drug delivery devices.

Liquid inhaler

The key to liquid inhalants is to ensure a high rate of drug deposition to the lungs. The American Aerokin company has a novel patented liquid aerosol technology, which is characterized by small size, light weight and no propellant. This electronically controlled liquid aerosol applicator has been developed into two special products, of which Aero Dose is a single or multiple dose liquid inhaler for the lungs to release a range of respiratory drugs, proteins and peptide drugs. Higher lower respiratory tract or deep lung deposition rate, the release of macromolecular drugs is superior to other new lung drug release technologies (such as dry powder inhalants), which can reduce the cost of unit doses, improve the accuracy of doses and protein stability; Aero Neb is a noiseless, lightweight and portable spray that can stably disperse small droplets of the same size. The US FDA has approved this drug delivery device. Newly marketed nasal inhalants have also increased in recent years. Mediimmm's nasal spray administration of live influenza virus vaccine was approved by the US FDA and became the first nasal spray administration of influenza vaccine for healthy adults in the United States. Schwartz Pharmaceuticals has partnered with Nastech Pharmaceuticals to market vitamin B12 nasal gels for the treatment of vitamin B12 deficiency. Aventis has developed a triamcinolone nasal aerosol using hydroflurane propellant for the treatment of nasal symptoms caused by allergic rhinitis ^[1] .