What Is a Triamcinolone Injection?

Triamcinolone injection, indication is intramuscular injection of triamcinolone (Triamcinolone injection) for diseases treated by corticosteroids, such as allergic diseases (for patients in a severely debilitated state, using traditional medicine When ineffective), skin diseases, diffuse rheumatoid arthritis, other connective tissue diseases. When oral corticosteroids are not feasible, intramuscular administration is significant for these diseases. Triamcinolone can be injected intra-articularly or intra-capsularly, and can also be administered directly to the tendon sheath or joint capsule. This method of administration can provide effective local, short-term treatment for pain, swelling of the joints, stiffness (these symptoms are typical symptoms of trauma, rheumatoid arthritis, osteoarthritis, synovitis, mucocystitis, tendonitis). In the treatment of diffuse joint disease, intra-articular injection of triamcinolone assists the traditional method of treatment. On the other hand, under the conditions of limited treatment conditions such as joint trauma or bursitis, intramuscular injection of triamcinolone provides a new option for treating diseases.

Drug Name: Triamcinolone injection
Drug type: Prescription drugs, medicines for medical workers' injuries

Special medicine: Doping
Use classification: Glucocorticoid

Triamcinolone injection composition

Triamcinolone Chemical Name: 9-fluoro-11, 21-dihydroxy-16, 17 [(1-methylethylene) bis (oxy) pregnostol-1,4-diene-3.20-dione

Molecular formula: C ₂₄ H ₃₁ FO ₆
Molecular weight: 434.48
The auxiliary materials are: benzyl alcohol, sodium carboxymethyl cellulose, polysorbate 80, sodium chloride, and water for injection.

Triamcinolone injection properties

This product is a suspension of fine particles. After standing, the fine particles sink and form a uniform milky white suspension after shaking.

Triamcinolone injection indications

Triamcinolone (Triamcinolone injection) intramuscularly for corticosteroid treatment, such as allergic diseases (for patients in a severely debilitated state, ineffective with traditional medicines), skin diseases, diffuse Rheumatoid arthritis, other connective tissue diseases. When oral corticosteroids are not feasible, intramuscular administration is significant for these diseases.
Triamcinolone can be injected intra-articularly or intra-capsularly, and can also be administered directly to the tendon sheath or joint capsule. This method of administration can provide effective local, short-term treatment for pain, swelling of the joints, stiffness (these symptoms are typical symptoms of trauma, rheumatoid arthritis, osteoarthritis, synovitis, mucocystitis, tendonitis).
In the treatment of diffuse joint disease, intra-articular injection of triamcinolone assists the traditional method of treatment. On the other hand, under the conditions of limited treatment conditions such as joint trauma or bursitis, intramuscular injection of triamcinolone provides a new option for treating diseases.

Triamcinolone injection specifications

1ml: 40mg

Triamcinolone injection dosage

Systemic use: For adults and children older than 12 years: the initial recommended dose is 60 mg. Depending on the patient's response, the applied dose can be between 40-80 mg. However, in some patients, the condition can be effectively controlled at a dose of 20 mg or less. For patients with hay fever or asthma caused by hay fever, when desensitization or other traditional therapies do not work, 40-100 mg can be given in a single injection during the hay season.
For children 6-12 years old, the initial recommended dose is 40 mg, but the patient's condition needs to be considered at the same time, not just the dose based on the age and weight of the patient. Due to differences in the duration of drug action, subsequent administration should be when symptoms reappear.
The injection should penetrate deep into the hip muscles for effective absorption of the drug. The recommended minimum needle length for adults is 4cm. For obese patients, the needle length should be longer. Each injection must not be in the same location.
Topical application: The dose used for joint cavity, intrasac, and intrathecal injection depends on the degree of the disease and the size of the disease site. In general, for adults, 10 mg in a small area and 40 mg in a large area can effectively reduce symptoms. Progressive diseases of multiple joint diseases can be administered in different parts, and the total dose can reach 80 mg without adverse reactions. Triamcinolone is usually effective in alleviating symptoms with a single topical administration, but sometimes multiple administrations are required. There are individual differences in the response of patients after treatment: sometimes they can relieve symptoms for a long time after one or two doses; sometimes they need to be re-dosed a few months after administration. The duration of symptom relief can be prolonged after continuous administration, so it is recommended to repeat the administration after the onset of the disease rather than at a predetermined time interval.
Local anesthesia is usually required for intra-articular, intrasaccular, or intrathecal injection. Observe during anesthesia. In such cases, anesthetics should be given to the soft tissue surrounding the injection site before topical administration. A small amount of anesthetic solution can also be injected at the joint site. Since there are abundant exudates at the joint site, part of the synovial fluid can be withdrawn before administration, taking care not to withdraw all the fluid. This will alleviate the symptoms and not over-dilute the injected medication. After anesthesia at the injection site, the corresponding intra-articular injection technique is applied to the joints. The drug is administered intramuscularly, and the drug can be injected directly into the lumen of the cyst. For the treatment of tendinitis, tenosynovitis, and trigger finger disease (Notta disease), the drug should be injected into the sheath instead of the tendon.
Tenosynovitis, periarthritis of the shoulder, rheumatic nodules, fibrous tissue inflammation, traumatic cysts, and knee ligament damage (such as congestive swelling of the lateral tendon) can be administered at the same time as the painful area.
Note: Shake well before use. Immediately after aspiration of the drug with a syringe to prevent drug precipitation. Take care to prevent infection, do not inject intravenously.

Triamcinolone adverse reactions

This product belongs to adrenal corticosteroids. There may be adverse reactions caused by adrenal corticosteroids. Please follow the instructions of the medicine to reduce the adverse reactions of the medicine. If there is any adverse reaction, the doctor or pharmacist should be notified in time.

Triamcinolone injection contraindications

This product is the same as other glucocorticoid drugs and should not be used for active gastric ulcers, tuberculosis, acute glomerulitis or any infection not stopped by antibiotics.

Precautions for triamcinolone injection

Protein intake should be taken during medication. Infectious diseases should be used in combination with antibiotics. Although few cases are reported to be allergic to corticosteroid injections, patients with a history of drug allergies should also use appropriate methods to prevent allergies when using this product. It is forbidden to receive smallpox vaccine during the administration. The treatment of tuberculosis should be limited to those with infectious or explosive tuberculosis, and anti-tuberculosis treatment should be given at the same time when corticosteroids are given. When patients have latent pulmonary tuberculosis or the tuberculosis test is positive, corticosteroids should be given close observation to prevent recurrence of tuberculosis.

Triamcinolone injection for pregnant and lactating women

This product can only be used in pregnant women and infants when it is very needed and under direct medical monitoring conditions.

Triamcinolone injection for children

Children under 6 years are disabled. Children with long-term use of corticosteroids must carefully monitor their growth and development.

Triamcinolone injection for the elderly

Elderly patients are prone to hypertension and diabetes with glucocorticoids. The use of glucocorticoids in elderly patients, especially postmenopausal women, can easily aggravate osteoporosis.

Triamcinolone injection drug interactions

When aspirin is used in combination with corticosteroids, patients with hypothrombinemia must be used with caution. Triamcinolone in combination with nonsteroidal anti-inflammatory drugs increases the risk of peptic ulcers and gastrointestinal bleeding. Interaction with barbiturate, phenyldantoin or Rihpampicin will lead to the induction of enzymes, and its metabolic consequences will limit the effectiveness of triamcinolone. The response to anticoagulants may be reduced, or in some cases the response may be enhanced. Interaction with potassium-releasing diuretics, such as salazines or furosemide, can lead to significant loss of potassium.

Triamcinolone injection overdose

Overdose can cause the following symptoms: anxiety, depression, gastrointestinal cramps or bleeding, petechiae, full moon face, and excessive tension. Prolonged treatment or sudden withdrawal of medication can cause adrenal insufficiency. Cushing's syndrome can be triggered by long-term high-dose corticosteroid treatment.
There is no effective countermeasure against adrenal corticosteroid overdose, so some adjuvant treatment should be taken. At present, the treatment of gastrointestinal bleeding caused by this drug is the same as that of peptic ulcer.

Triamcinolone injection pharmacology and toxicology

Triamcinolone injection is a long-acting glucocorticoid with strong and long-lasting anti-inflammatory and anti-allergic effects. Its anti-inflammatory and anti-allergic mechanism is as follows:
Inhibit the phagocytosis and processing of antigen by macrophages;
Inhibit the transformation of B cells into plasma cells and interfere with humoral immunity;
Stabilize the lysosomal membrane and reduce the release of hydrolytic enzymes in the lysosome;
Inhibit the migration of leukocytes and macrophages out of blood vessels and reduce the inflammatory response;
Increase the stability of mast cell granules, reduce histamine release, thereby reducing vasodilation and reducing capillary permeability;
Increase blood vessel sensitivity, strengthen contractility, reduce local congestion and extravasation of body fluids;
It has a direct inhibitory effect on fibroblast DNA and inhibits the formation of granulation tissue.

Pharmacokinetics of triamcinolone injection

This product is effective after 1 to 2 hours of intramuscular injection. The maximum effect is achieved within 1 to 2 days. The effect can be maintained for more than 2 to 3 weeks. It is distributed in liver, plasma, cerebrospinal fluid, pleural fluid and ascites. Excluded from urine.

Triamcinolone injection storage

Protect from light and store below 25 ° C to avoid freezing.

Triamcinolone injection packaging

Silicone-coated glass bottles for injection, 1 bottle per small box

Triamcinolone injection expiration date

36 months

Triamcinolone injection standard

Import dosage of imported drugs JX20010128 ^[1]