What Is an Anti-Diarrheal?

Drugs to control diarrhea. Antidiarrheal effect is achieved by reducing intestinal motility or protecting the intestine from irritation. It is suitable for severe diarrhea or chronic chronic diarrhea to prevent the body from excessive dehydration, water and salt metabolism disorders, digestion and nutritional disorders.

Introduction to antidiarrheal drugs

Antidiarrheal drugs are symptomatic treatments for diarrhea. The antidiarrheal effect is achieved mainly by reducing intestinal motility or protecting the intestine from irritation. Antidiarrheal drugs are suitable for severe diarrhea or chronic chronic diarrhea to prevent excessive dehydration, dysregulation of water and salt metabolism, digestive or nutritional disorders. According to their pharmacological effects, they can be divided into two categories:

Drugs that change the function of the intestinal tract. These drugs can increase gastrointestinal tension, inhibit intestinal peristalsis, and prevent propulsive contractions. Representative drugs include morphine, compound camphor tincture, diphenoxylate, loperamide and so on.

Intestinal mucosal protective agents are also called adsorbents. It can adsorb intestinal gas, bacteria, virus and exotoxin through surface adsorption to prevent it from being absorbed or damage the intestinal mucosa. Medicines include medicinal charcoal, white clay, Smecta and so on. Among them is the drug Smecta. The main component is dioctahedron montmorillonite particles, which has a strong adsorption effect on viruses, bacteria and their toxins.

Detailed antidiarrheal medicine

What types of antidiarrheal medicines?

Antidiarrheal drugs can reduce the intestinal motility or protect the intestines from irritation to achieve antidiarrheal purposes, generally divided into the following categories.

(1) Opioids and their derivative preparations (such as loperamide hydrochloride, diphenoxylate, compound camphor tincture, etc.): Mainly play an antidiarrheal effect by increasing gastrointestinal tension, inhibiting intestinal movement, and preventing advancing contraction.

(2) Adsorbents (such as medicinal carbon): Adsorb water, air, bacteria, viruses, poisons in the intestine through the surface adsorption of drugs, prevent them from being absorbed by the intestinal mucosa or damage the intestinal mucosa and stop diarrhea.

(3) Astringent (such as tannic acid protein): Protects the intestine from harmful factors and reduces secretion by forming a protective layer of coagulated protein.

(4) Protective drugs (such as basic bismuth carbonate): it has the effect of forming a protective film of the intestinal tract, so that it is not stimulated to relieve diarrhea.

(5) Others: It can prevent diarrhea by treating intestinal indigestion, adjusting the growth and composition of normal intestinal flora, bacteriostasis or sterilization, such as lactase, bifidobacteria, berberine hydrochloride, etc.

What does an antidiarrheal medicine do?

Because diarrhea is caused by many different causes, the application of antidiarrheal drugs is a non-specific "palliative" treatment, which cannot produce a "curative effect". Antidiarrheal drugs reduce the number of defecations, the amount of defecation, and the symptoms associated with defecation (such as abdominal pain) to prevent the body from excessive dehydration, water and salt metabolism disorders, electrolyte disorders, digestion and nutritional disorders. Therefore, while applying antidiarrheal treatment, the implementation of treatment should not be ignored, so as not to affect the disease.

Under what circumstances should the drugs that inhibit bowel movements be used?

These drugs are suitable for patients with severe diarrhea.

Such drugs can cause intestinal peristalsis to slow down, thereby increasing the invasion of tissues by pathogenic microorganisms and their toxins, or slowing the clearance of pathogenic microorganisms, and are therefore contraindicated in patients with aggressive enteritis manifestations (such as high fever, chills, blood or pus and blood) , And patients with severe ulcerative colitis or who may develop toxic megacolon.

Antidiarrheal medicine classification

(1) Opioids and their derivatives: These drugs can increase gastrointestinal tension, inhibit intestinal peristalsis, and prevent advancing contractions, thus slowing the speed of food advancement, allowing sufficient time for water to absorb and stop diarrhea. Drugs include compound camphor tincture, phenelidine, loperamide hydrochloride (easy to stop) and so on.

(2) Adsorbent: Absorb the gas, bacteria, virus, and exotoxin in the intestine through the adsorption of the drug surface, and prevent them from being absorbed by or damage the intestinal mucosa. Medicines include medicinal charcoal and white clay.

(3) Convergent protective agent: the drug forms a protective film on the intestinal mucosa to prevent it from irritation. Drugs include tannic acid protein and bismuth hypocarbonate.

(4) Others: a. Stop diarrhea by treating intestinal indigestion: lactase. b. Aspirin is achieved by inhibiting intestinal prostaglandin synthesis and inhibiting cell secretion. c. Antidiarrheal through bacteriostatic or bactericidal: bacteriotrophic, berberine hydrochloride and intestinal bactericide. d. Antidiarrheal by complexing with bile acid in the intestine: cholestyramine. e. Adjust the growth and composition of normal intestinal flora: intestinal growth, Lizhu Changle.

Antidiarrheal

Antidiarrheal drugs

The antidiarrheal drug Smecta has a strong adsorption effect on the bacteria, viruses and toxins and gases produced in the digestive tract, thereby playing an antidiarrheal effect, but at the same time its strong adsorption effect will also affect antibiotics taken at the same time, etc. Drugs, which quickly adsorb the components of norfloxacin and the active probiotics in Pefilcon, and combine with them, so that the components of these two drugs cannot be fully absorbed by the gastric mucosa, and the efficacy is naturally reduced.

Not only that, many commonly used stomach medicines and antidiarrheal medicines have a certain adsorption effect. Most organic medicines such as antibiotics and vitamins may be adsorbed by the above medicines, making them unable to be absorbed by the gastrointestinal mucosa and affecting the efficacy.

Therefore, when taking medicine, stomach medicines and antidiarrheal medicines should be taken separately from antibiotics as much as possible. If you need to take them at the same time, you should stagger the time and take at least one hour away from other medicines. Pefilcon and others can adjust the intestinal flora balance. Drugs should be taken two hours apart from antibiotics. Effective antibacterial drugs should be used in combination with infectious diarrhea. Antidiarrheal drugs should not be used alone. ^[1]