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Opsumit's Chinese name is Macitatan, and the pharmaceutical company is Actelion Pharmaceuticals Inc.

Opsumit

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Opsumit's Chinese name is Macitatan, and the pharmaceutical company is Actelion Pharmaceuticals Inc.

Product Name: Opsumit
Common name: macitentan
Chinese name: Maxitantine Pharmaceuticals: Actelion Pharmaceuticals Inc.
Indication: Pulmonary hypertension (PAH).
Dosage specifications: This product is a film-coated tablet, 10 mg / tablet, the recommended dosage is 10 mg / day.
Mechanism of action: Massitidine is an endothelin receptor antagonist. Endothelin and its receptors (ETa and ETb) mediate a variety of harmful effects, such as vasoconstriction, fibrosis, hyperplasia, hypertrophy, inflammation, etc., endothelin is up-regulated in patients with pulmonary hypertension.
Clinical trials: 742 patients with PAH were divided into placebo group, 3 mg macetitant group, and 10 mg macetitant group, with death or malignant events (such as atrial septal ostomy, lung transplantation, 15% reduction in six-minute walking distance) As the primary clinical endpoint, 46.4% and 31.4% of patients in the placebo group and 10 mg of metformin group respectively reached the primary clinical endpoint, and the death tolls in the two groups were 17 and 16 respectively.
Boxed warning: embryo toxicity (banned in pregnant women).
Supplementary note: On October 18, 2013, the US Food and Drug Administration (FDA) announced that macitentan has been approved for the treatment of pulmonary hypertension (PAH). It is not currently listed in the country and is marketed in the United States by Haoeyou Pharmacy, a subsidiary of the California Healthcom Group.