What Is an Atropine Injection?

Atropine is an M-choline receptor blocker. Atropine injection is mainly used as an injection for treating gastrointestinal spasm and gastric motility. It can also be used for slow heart attacks such as sinoatrial block and atrioventricular block caused by vagal overexcitation Arrhythmia can also be used for ventricular ectopic secondary to secondary sinus node dysfunction.

Atropine injection

Atropine is an M-choline receptor blocker. Atropine injection is mainly used as an injection for treating gastrointestinal spasm and gastric motility. It can also be used for slow heart attacks such as sinoatrial block and atrioventricular block caused by vagal overexcitation. Arrhythmia can also be used for ventricular ectopic secondary to secondary sinus node dysfunction.

Drug Name

Atropine injection

Foreign name

ATROPINEINJECTION

Drug type

Gastrointestinal antispasmodic and gastric motility drugs

Character

Colorless transparent liquid

[Common name] Atropine injection [English name] ATROPINEINJECTION
[Pinyin name] ATUOPINZHUSHEYE
[Drug category] Gastrointestinal antispasmodic and gastric motility drugs [Character] Colorless and transparent

[Indications] 1. Various visceral colic, such as gastrointestinal colic and bladder irritation. It has poor curative effect on biliary colic and renal colic; 2. administration before general anesthesia, severe night sweats and salivation; 3. slow sinus atrial block and atrioventricular block caused by excessive vagal nerve excitement, It can also be used for ventricular ectopic secondary to sinus node hypofunction; 4. Anti-shock; 5. Rescue organophosphate poisoning.
[Usage and Dosage] 1. Subcutaneous, intramuscular or intravenous injection commonly used for adults: 0.3 ~ 0.5mg each time, 0.5 ~ 3mg a day; Extreme amount: 2mg once. Child subcutaneous injection: 0.01 ~ 0.02mg / kg each time, 2 ~ 3 times a day. Intravenous injection: for the treatment of Asthma syndrome, 0.03 ~ 0.05mg / kg each time, repeated once every 15 minutes if necessary, until the complexion flushes, the circulation improves, the blood pressure rises, and the interval is extended until the blood pressure stabilizes. 2. Antiarrhythmic adults can be injected 0.5 ~ 1mg intravenously, once every 1 ~ 2 hours as needed, the maximum amount is 2mg. 3. Detoxification 1) For Ass syndrome caused by antimony, 1 ~ 2mg intravenously, then 1mg after 15 ~ 30 minutes. If the patient has no seizure, 1mg is injected subcutaneously or intramuscularly every 3 ~ 4 hours as needed . 2) For organophosphate poisoning, intramuscular or intravenous injection of 1 ~ 2mg (increase 5 ~ 10 times in severe organophosphate poisoning), repeat every 10 ~ 20 minutes until the bruises disappear, continue to use the medicine until the condition is stable, then With maintenance, sometimes it takes 2 to 3 days. 4. Anti-shock improve circulation. Adults generally use 0.02 ~ 0.05mg / kg body weight, dilute with 50% glucose injection, or dilute with glucose water. 5. Medication before anesthesia 0.5 to 1 hour before surgery, intramuscular injection of 0.5 mg, pediatric subcutaneous injection dosage: 0.1 mg for people weighing less than 3 kg, 0.2 mg for 7 to 9 kg, 0.3 mg for 12 to 16 kg, and 20 to 27 kg for 0.4mg, 0.5mg above 32kg.
[Adverse reactions] The adverse reactions caused by different doses are roughly as follows: 0.5mg, mild heart rate slows, slightly dry mouth, and less sweat; 1mg, dry mouth, accelerated heart rate, and slightly dilated pupils; 2mg, palpitations, significant dry mouth 5. Pupil dilation, sometimes blurred vision; 5mg, the above symptoms are aggravated, and have unclear speech, irritability, dry skin, fever, difficulty in urination, and reduced bowel movements; above 10mg, the above symptoms are more severe, the pulse rate is weak, and the center The excitement is severe, the breathing accelerates and deepens, and delirium, hallucinations, and convulsions occur; in severe poisoning, the central excitement can be turned into inhibition, resulting in coma and respiratory paralysis. The minimum lethal dose is about 80 to 130 mg for adults and 10 mg for children. Fever, fast pulse, diarrhea and caution for the elderly.
[Contraindications] Those with glaucoma, prostate hypertrophy, and high fever are prohibited.
[Precautions] 1. Those who are intolerant to other belladonna alkaloids are also intolerant to this product. 2 Pregnant women with intravenous atropine can make fetal tachycardia. 3. This product can be secreted into milk, and has the effect of inhibiting lactation. 4 Infants and young children are very sensitive to the toxicity of this product, especially in children with spastic paralysis and brain injury. The response is stronger. When the ambient temperature is high, there is a risk of sudden rise in body temperature due to closed sweat. It should be closely observed during application. . 5 Elderly people are prone to anti-M choline-like side effects, such as dysuria, constipation, dry mouth (especially men), and also easily cause undiagnosed glaucoma. Once found, the drug should be discontinued. This product is especially easy for elderly people to cause sweat secretion to decrease and affect heat dissipation, so use it with caution in summer. 6. The following situations should be used with caution: 1) brain damage, especially children; 2) heart disease, especially arrhythmia, congestive heart failure, coronary heart disease, mitral stenosis, etc .; 3) reflux esophagitis, esophagus Weakening of the stomach and relaxation of the lower esophageal sphincter can delay gastric emptying, thereby promoting gastric retention and increasing gastric-esophageal reflux; 4) disabled in glaucoma patients, and latent glaucoma in patients over 20 years of age , There is a risk of induction; 5) ulcerative colitis, intestinal motility is reduced when used in large amounts, which can lead to paralytic intestinal obstruction and can aggravate toxic megacolon; 6) urinary tract infection caused by enlarged prostate (bladder tension (Reduction) and obstructive urinary tract diseases, which can lead to complete urinary retention. 7. Interference to diagnosis: The phenol sulfophthalein test can reduce the discharge of phenol sulfophthalein.
[Medication for pregnant women and lactating women] The safety of this product to pregnant women is not clear, and the pros and cons of medication should be considered for pregnant women. This product can be secreted into milk and has a lactation inhibiting effect. Use with caution in lactating women.
[Children's medication] Children's brain is sensitive to this product, especially when fever, it is easy to cause central disorders, use with caution.
[Medication for elderly patients] Elderly patients, especially those over 60 years of age, are easily affected by glandular secretion. Use this product with caution.
[Storage] Keep away from light, keep in a cool, airtight place.