What Is Antiandrogen Therapy?

Antiandrogen refers to drugs that antagonize androgens at the target organ receptor level, and are mainly androgen receptor antagonists (antagonist). In fact, substances that inhibit the biosynthesis and metabolism of androgens and gonadotropins, as long as they can reduce the production and function of androgens, are classified as antiandrogens. According to the chemical structure, it is divided into steroidal antiandrogens and nonsteroidal antiandrogens.

Antiandrogens

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Environmental antiandrogen (Environmental antiandrogen) is a large class of endocrine disruptors that can compete with androgen receptors (AR) to prevent the combination of androgens and AR in the body, thereby inhibiting androgen activity and exerting antiandrogenic

Environmental antiandrogen pollution

Effect. Its impact on human reproductive health has aroused widespread concern, so the establishment of a fast and effective method for screening and testing environmental anti-androgens has become an urgent task. Some chemicals in the environment can interfere with normal endocrine functions. They have effects similar to hormones in the body or hormones in antibodies, which affect the reproductive development and health of humans or other organisms. Vinclozolin and its metabolites M1 and M2, metabolites of DDT p, p2DDE, methoxychlor, promidmidone and synthetic pyrethroids, etc., can interact with androgens The receptor (AR) competitively prevents the combination of androgen and AR in the body, thereby inhibiting androgen activity and exerting an antiandrogenic effect. They can affect both normal hormone production, release, transport, metabolism or clearance, as well as homologous receptor binding and P or subsequent intracellular receptor effects. Both the effects of endogenous hormones (agonists) and the effects of endogenous hormones (antagonists) can be inhibited.

Environmental antiandrogens can interfere with the effects of androgens through different molecular mechanisms, affecting reproduction and development, and may have adversely affected human health.