What factors affect a sufficient dose of carbamazepine?

Anticonvulsive drug carbamazepine is most commonly used in the treatment of neuropathic pain, trigeminal neuralgia and seizure disorders such as epilepsy. Carbamazepine is also used as a therapeutic supplement in the treatment of schizophrenia and has shown some promise as a replacement for lithium in the treatment of bipolar disorder. Like many drugs in their class, the drug was experimentally prescribed for a wide range of unapproved uses, including a disorder of hyperactivity with lack of attention, interrupted explosive disorder, phantom limb syndrome, complex regional pain syndrome, paroxysmal extreme pain syndrome, neuromyotony and post -traumatic stress. However, due to the risk of side effects threatening life, this drug should only be used only if necessary and at the lowest adequate dosage level. Factors such as the patient's condition, the age and the drug regime may affect the initial dose of carbamazepine that the patient should receive, requires dose adjustment.

KdyPoskytováníThis drug for any condition should be used low initial daily carbamazepine dose and gradually increased to the point of therapeutic efficiency. Jakmile je daná dávka karbamazepinu schopna zvládnout stav, může být hladina pomalu snížena na nejnižší efektivní dávku. If it switches the patient to carbamazepine from another anti -vvulsant drug, it is essential that the patient is carefully monitored, while the carbamazepine dose gradually increases and other drugs are reduced. Výjimkou je lék fenytoin, protože může být nutné zvýšit, pokud je kombinován s karbamazepinem, spíše než snížený.

If the patient has never used any anticonvulsive medicines before, then the initial dose of carbamazepine with carbamazepine 100 mg should be administered to treat epilepsy. Může být uvedena dávka údržby 800 až 1 200 mg, i když ve většině CASES Denní dávka by neměla překročit 1 200 mg. Zvýšení o 200 mg na počáteční denní dávku bywas to be evaluated every week.

children under 13 years of age should receive lower initial and maximum dose of carbamazepine. Those between the age of six and 12 years of age can be given 100 mg of immediate or extended forms of release twice a day, plus a maintenance dose up to a maximum of 800 mg. The initial dose for children under six years of age should be a total daily dose of carbmesepine 10 to 20 mg per kg body weight in two to three divided doses. Increasing the dose should be evaluated every week, and children of younger six do not take more than 35 mg/kg per day and children between six and 12 do not take more than 1,000 mg per day.

The

dose of carbamazepine for the treatment of diabetic neuropathy is initially 100 mg administered orally twice a day, with 100 mg increasing to a daily dose rated every two weeks. The maintenance dose between 600 and 1,200 mg in three reads can be administered in three or four doses. In the treatment of trigeminal neuralgia can be used the same initial dose, alE The recommended maintenance dose is only 400 to 800 mg daily. The dose increase can be up to 200 mg daily in two divided doses. An attempt to reduce or discontinue the use of this drug for the treatment of neuralgia should be made every three months.