What Is Antipyrine?

Antipyrine Chinese aliases: Antipyrine, Aminopyrine, 1,5-Dimethyl-2-phenyl-3-pyrazolinone, Finazone, Dimethylphenylpyrazolone, English name: Antipyrine.

Chinese name

Chinese alias: phenazine; dimethylphenylpyrazolone; 2,3-dimethyl-1-phenyl-5-pyrazolone;

English name: antipyrine

English alias: 2,3-dimethyl-1-phenyl-3-pyrazolin-5-one; Azophen; Sedatin;

CAS number: 60-80-0

Molecular formula: C ₁₁ H ₁₂ N ₂ O

Molecular weight: 188.22600

Exact mass: 188.09500

PSA: 26.93000

LogP: 1.48440 ^[1]

Appearance and properties: colorless crystal

Density: 1,19 g / cm ³

Melting point: 109-111 ° C

Boiling point: 319 ° C

Flash point: 109.4ºC

Refractive index: 1.553

Water solubility: 1000 g / L (20 ºC)

Storage conditions: storeroom ventilated, low temperature and dry ^[1]

Packing level: III

Hazard category: 6.1 (b)

Customs Code: 2933110000

Dangerous Goods Transport Code: 3249

WGK Germany: 1

Danger category code: R22; R36 / 37/38

Safety instructions: S26-S36-S37 / 39

RTECS number: CD2450000

Dangerous goods mark: Xn ^[1]

CAS number: 60-80-0

MDL number: MFCD00003146

EINECS number: 200-486-6

RTECS number: CD2450000

BRN number: 157775

PubChem number: 24891029 ^[2]

1. Molar refractive index: 54.55

2. Molar volume (cm ³ / mol): 162.7

3. Isotonic specific volume (90.2K): 416.1

4. Surface tension (dyne / cm): 42.7

5. Polarizability (10 ^-24 cm ³ ): 21.62 ^[2]

1. Uncertain number of chemical bond stereocenters: 0

2.Number of hydrogen bond donors: 0

3.Number of hydrogen bond acceptors: 2

4.Number of rotatable chemical bonds: 1

5.Number of covalent bond units: 1

6. Topological molecular polar surface area 23.6

7.Number of heavy atoms: 14

8.Surface charge: 0

9.Complexity: 267

10.Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0 ^[2]

Derived from 1-phenyl-3-methylpyrazolone-5 by methylation and hydrolysis. In a dry methylation tank, add pyrazolone and then dimethyl sulfate, raise the temperature to 160 ° C, react for 6 hours, and heat the water to boil for 2 hours. The methylation reaction product was put into a hydrolysis tank containing a sodium hydroxide solution, and was hydrolyzed by stirring at 100-110 ° C for 3 hours. After standing and layering, the antipyrine oil layer was placed in a crystallization tank, diluted with distilled water, stirred, and cooled to below 10 ° C, crystals were precipitated, filtered, washed with water, and dried to obtain crude antipyrine. The crude product is recrystallized with distilled water, and the activated carbon is decolorized to obtain a finished product. The methylation operation can also use methyl chloride or methyl bromide as a raw material, make such methylation reagent into a methanol solution, and slightly react with 1-naphthyl-3-methylpyridone by stirring. The methanol was then distilled off, the reaction was dissolved in water, made slightly alkaline with sodium hydroxide, antipyrine was extracted with benzene, recrystallized from benzene, and finally purified with activated carbon and recrystallized with water. The other method is to prepare by equimolar N, N-phenylmethylhydrazine and ethyl acetoacetate under heating in an oil bath at 130-160 ° C. Antipyrine was extracted from the thick oily liquid with boiling water, and then water was evaporated to obtain crystals. ^[2]

1. Analytical reagents for nitric acid, nitrous acid and iodine. Determine the elements that can form complex cations (such as bismuth, tin, antimony, mercury, etc.). Gravimetric determination of titanium.

2. This product is an antipyretic and analgesic. This type of non-steroidal anti-inflammatory drug has strong antipyretic and analgesic, anti-inflammatory and anti-rheumatic effects. However, due to serious adverse reactions, clinical applications have been gradually reduced, and some of the older varieties have gradually been eliminated. Tablets such as antipyrine, aminopyrine, and anaijin are all obsolete drugs announced by the Ministry of Health in September 1982. Antipyrine is an analytical reagent. ^[2]

Common name: Antipyrine

English name: Phenazone

Chinese aliases: Ambi, Antipyrin, Finazong

English aliases: Analgesine, Antipyrin, Antipyrine, Fenazona

[Character]

Chemical formula of antipyrine

Colorless crystal or white crystalline powder, odorless and slightly bitter. Soluble in water, ethanol, and chloroform. Slightly soluble in ether.

[Indications]

It is often used in combination with other antipyretic and analgesics. Its tablets have been phased out.

Dosage

As directed by your doctor.

Adverse reactions

Toxic, prone to rash, cyanosis, indigestion, insomnia, depletion and granulocytosis. ^[2]