What is the use of inhaled colistin?
Colistin is an antibiotic that was first used in medicine in 1959. Although the drug fell from kindness at 70 years due to the potential of serious side effects, doctors at the beginning of the 21st century brought the drug back to the use of infections caused by organisms resistant to more modern drugs. Inhaled colistin is primarily used as treatment of lung infections of people with cystic fibrosis, but can also be used to treat pulmonary infections in other people who do not respond to other antibiotics.
Antibiotic resistance is an important problem facing medicine. The term "resistance" describes a situation where the bacterial species has killed a specific antibiotic, but is now immune. This represents problems when a person is infected with bacteria and regular treatment does not work. To fight against this, doctors must have other antibiotics in a reserve that can cure the infection.
Inhaled colistin is an example of antibiotics that the doctor may need to use the treatment of infection instead of regular treatment. CollisTIN is effective in killing bacteria that are part of a gram of a negative group. This group of bacteria contains some of the most important infectious organisms. One example is pseudomonas aeruginosa , which can be fatal for people with cystic fibrosis.
The main reason why Kolistin was rejected in favor of other drugs was concerns about security. This can cause kidney and nervous system damage. However, people suffering from dangerous lung infections may rather risk side effects against the potentially fatal effects of infection. The advantage of inhalation colistin over intravenous colistin for pulmonary infections is that the aerosolized drug can get directly into the affected tissues, but the doctor can also administer an antibiotic as an injection, so the drug gets into the Ntire.
In general, the main use of inhalation colistin since 2011 for people with pulmonary inDrug -resistant feces, who also suffer from cystic fibrosis. Sometimes, however, the drug can also be used in people who do not have cystic fibrosis, but who have lung infections threatening life such as pneumonia. In these cases, inhaled colistin may be used as a last option due to the risk of serious side effects. Further potential use of inhalation colistin, since 2011, is the preparation of patients with lung transplantation for surgical procedure. Theoretically, colistin can kill existing bacteria strains that are resistant to many antibiotics, so when the patient receives new lungs, the likelihood of infection is reduced by drug -resistant bacteria.