What Is Atropine Sulphate?

Atropine sulfate is an anticholinergic drug used in the treatment of gastrointestinal tract, biliary colic, mydriatic optometry, keratitis, organophosphorus pesticide poisoning, and septic shock. The storage conditions are easy to absorb moisture, and the storage temperature is 0-8 ° C. This product binds to the M choline receptor and fights the muscarinic effects of acetylcholine and other choline-like drugs. It mainly relieves the spasm of smooth muscle, inhibits the secretion of glands, and relieves the inhibition of the heart by the vagus nerve, so that the heartbeat is accelerated, the pupils are dilated, and the intraocular pressure is increased; the respiratory center is excited.

Atropine sulfate

Atropine sulfate is an anticholinergic drug used in the treatment of gastrointestinal tract, biliary colic, mydriatic optometry, keratitis, organophosphorus pesticide poisoning, and septic shock. The storage conditions are easy to absorb moisture, and the storage temperature is 0-8 ° C. This product binds to the M choline receptor and fights the muscarinic effects of acetylcholine and other choline-like drugs. It mainly relieves the spasm of smooth muscle, inhibits the secretion of glands, and relieves the inhibition of the heart by the vagus nerve, so that the heartbeat is accelerated, the pupils are dilated, and the intraocular pressure is increased; the respiratory center is excited.

Chinese name

Atropine sulfate

Product ID

YCY078

English name

Atropine sulfate

CAS number

55-48-1

Chinese alias: atropine sulfate; atropine sulfate (with a crystal water); atropine sulfate

Chemical name: - (hydroxymethyl) phenylacetic acid-8-methyl-8-azabicyclo [3.2.1] -3-octyl sulfate monohydrate

English alias: atropette; atropine, sulfate (2: 1); atropiniumsulfate; atropinsal; atropinsiran; atropinsulfat; atropinysiarczan

Linear molecular formula:

Atropine Sulfate Product Name: Atropine Sulfate, Belladine Sulfate, DL-Amberine English Name: atropine sulfate monohydrate Atropsiol CAS Number: 5908-99-6 Molecular Formula: (C17H23NO3) 2? H2SO4? H2O Molecular Weight: 694.86 Properties: This product is no Color crystal or white crystal powder. Melting point is 190-194 ° C. Its 1g crystal can be dissolved in 0.4ml water, 2.5ml boiling alcohol, 5ml alcohol, 2.5ml glycerol, 420ml chloroform, 3000ml ether. It is odorless, weatherable and easily deteriorated when exposed to light. The taste is extremely bitter. Very toxic. Main uses: Anticholinergic drugs, which can relieve smooth muscle spasm and inhibit glandular secretion. For gastric and duodenal ulcers, gastrointestinal tract, kidney, biliary colic, mydriatic examination and optometry, keratitis, iridocyclitis, and pre-anesthetic administration, etc. Acute cardiogenic cerebral ischemic syndrome caused by poisoning, septic shock and antimony preparations.

[Function and use]

This product is an anticholinergic drug that binds to the Mcholine receptor and fights the muscarinic effects of acetylcholine and other choline-like drugs. It mainly relieves the spasm of smooth muscle, inhibits the secretion of glands, and relieves the inhibition of the heart by the vagus nerve, so that the heartbeat is accelerated, the pupils are dilated, and the intraocular pressure is increased; the respiratory center is excited. Clinical use: rescue toxic shock and relieve

[Dose and usage]

1 Commonly used, subcutaneously or intravenously, 0.3mg 0.5mg / time, 0.5mg 3mg / day. Extremely, subcutaneously or intravenously, 1 mg / time. Infants are poorly tolerated and can be poisoned to death from 0.2mg to 10mg. Oral, 0.3mg ~ 0.5mg / time, 3 times / day, before meals. Extreme dose 1mg / time, 3mg / day. Pediatric 0.01mg / kg each time.

2 Administration before anesthesia, subcutaneous injection of 0.5mg.

3 Organophosphate poisoning, mild poisoning by intramuscular injection of 0.5mg ~ 1.0mg / time, 2 ~ 3 times / day, moderate poisoning by intramuscular or intravenous injection of 1mg ~ 2mg / time, once / 0.5 ~ 2 hours . When the condition improves, reduce the amount as appropriate. Severely poisoned coma should be applied early enough and repeatedly. General intravenous injection, 2mg / time, once every 15-30 minutes until it appears

side effect

1 Common dry mouth, palpitations, dilated pupils, blurred vision, dry skin, elevated body temperature, and urinary retention.

2 Excessive doses, symptoms of central nervous excitement such as irritability, delirium, and convulsions. Excessive excitement turns into suppression, difficulty breathing, and death.

The relief of atropine poisoning is mainly symptomatic, such as using a small dose

Method name:

Atropine sulfate-Determination of atropine sulfate-Non-aqueous titration method

Application:

This method uses a non-aqueous solution titration method to determine the content of atropine sulfate ((C17H23NO3) 2 · H2SO4).

This method is applicable to the determination of atropine sulfate.

Method principle:

The test sample is accurately weighed, plus

2010 Chinese Pharmacopoeia revised and updated content

Atropine sulfate

Liusuan Atuopin Atropine Sulfate

Page number: 2005 Part Two of Chinese Pharmacopoeia -735

[Revised]

Take this product for melting point. After drying at 120 ° C for 4 hours, immediately measure it according to the law (Appendix VI C). The melting point must not be lower than 189 ° C, and it will decompose at the same time when melting.

[Inspection] Take this product after losing weight and dry it at 120 for 4 hours. The weight loss should not exceed 5.0% (Appendix L).

[Updated]

[Inspection] Take this product and add water to make a solution containing 0.5mg of atropine sulfate per 1ml as the test solution; precisely measure 1ml of the test solution, place it in a 100ml volumetric flask, dilute to the mark with water, shake As a control solution. According to high performance liquid chromatography (Appendix VD). Using octadecylsilane bonded silica as a filler, 0.05 mol / L potassium dihydrogen phosphate solution (containing 0.0025 mol / L sodium heptane sulfonate) monoaceton (84:16) (adjust the pH value to 5.0 ) Is the mobile phase, the detection wavelength is 225nm; the resolution between the atropine peak and the adjacent impurity peaks should meet the requirements. 25 l of the control solution was accurately measured and injected into the liquid chromatograph, and the detection sensitivity was adjusted so that the peak height of the main peak was about 20% of the full range. Then, 25 l of each of the test solution and the control solution were accurately measured and injected into the liquid chromatograph, and the chromatography was recorded. The figure is twice the retention time of the main component peak. If there is an impurity peak (except for the solvent peak) in the chromatogram of the test solution, the sum of the area of each impurity peak must not be greater than the area of the main peak of the control solution (1.0%).

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