What Is Barbiturate Withdrawal?

Barbiturates (also known as Barbiturate) are a class of sedatives that act on the central nervous system and are derivatives of barbituric acid. Their applications range from mild sedation to complete anesthesia. Used as anxiolytics, sleeping pills, antispasmodics. Long-term use can lead to addiction. Barbiturates have been largely replaced clinically by benzodiazepines. The latter have far fewer side effects than the former. However, barbiturates are still used in the treatment of general anesthesia or epilepsy.

Barbiturates

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Synthesis of diethyl malonate. Take the preparation of isoprene barbiturate as an example: under the catalysis of ethylene glycol, the alpha carbon of diethyl malonate CH2 (COOC2H5) 2 is firstly loaded with a larger isoamyl group, and then a smaller ethyl group. Group, and finally condensed with urea CO (NH2) 2 ring closure.

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