What Is Buspirone HCL?

Buspirone hydrochloride tablets, the indication is for the treatment of generalized anxiety and other anxiety disorders.

Drug Name: Buspirone Hydrochloride Tablets

Drug type: Prescription drugs, medicines for medical workers' injuries
Use classification: Other anxiolytics

Buspirone Hydrochloride Tablets Ingredients

The chemical name, chemical structure formula, molecular formula and molecular weight of the active ingredient buspirone hydrochloride are as follows:
Chemical name: 8-azaspiro [4,5] decane-7,9-dione, 8- [4- [4- (2-pyrimidinyl) -1-piperazinyl] butyl] hydrochloride .
Chemical Structure:

Molecular formula: C ₂₁ H ₃₁ N ₅ O ₂ · HCl
Molecular weight: 421.97

Properties of Buspirone Hydrochloride Tablets

This product is a white tablet.

Indications of Buspirone Hydrochloride Tablets

This product is used to treat generalized anxiety and other anxiety disorders.

Buspirone hydrochloride tablets specifications

5mg

Buspirone hydrochloride tablets usage dosage

Orally, start with 5 mg (1 tablet) once, 2 to 3 times a day. The second week can be increased to 10mg (2 tablets), 2 to 3 times a day. The commonly used therapeutic dose is 20mg to 40mg (4 to 8 tablets) a day.

Adverse reactions of buspirone hydrochloride tablets

Dizziness, headache, dry mouth, nausea, vomiting and gastrointestinal disorders. Insomnia, sweating, constipation, tachycardia, blurred vision, loss of appetite, etc. are mild, and patients can generally tolerate them without special treatment. Occasionally an abnormal electrocardiogram (T wave low level, first degree atrioventricular block) and a slight increase in serum alanine chlorotransferase.

Buspirone hydrochloride tablets contraindications

1. Glaucoma, myasthenia gravis, leukopenia, and those who are allergic to this product are prohibited.
2. Banned for pregnant and lactating women.
3 Children disabled.

Precautions for buspirone hydrochloride tablets

1. Use with caution in patients with heart, liver, and kidney dysfunction and those with pulmonary dysfunction.
2. Periodically check liver function and white blood cell count during medication.
3 It is not advisable to drive vehicles, operate machinery or work at height during medication. Do not drink alcohol while taking the medicine.

Buspirone hydrochloride tablets for pregnant and lactating women

Banned for pregnant and lactating women.

Buspirone hydrochloride tablets for children

Disabled.

Buspirone hydrochloride tablets for elderly

Reduced dose.

Buspirone hydrochloride tablets drug interactions

Combining this product with monoamine oxidase inhibitors can increase blood pressure.

Buspirone hydrochloride tablets overdose

This experiment was not performed and there are no reliable references.

Pharmacology and Toxicology of Buspirone Hydrochloride Tablets

Pharmacological effect: This product is a 5-HT1A receptor agonist. Animal experimental models show that this product reduces the excessive 5-HT activity of anxiety and produces anti-anxiety through selective binding with 5-HT1A receptor in the brain effect. This product has no sedative, muscle relaxation and anticonvulsant effects.
Toxicology study: The experiment was not performed and there are no reliable references.

Pharmacokinetics of Buspirone Hydrochloride Tablets

Oral absorption is fast and complete, reaching the peak plasma concentration in 0.5 to 1 hour. There is a first-pass effect in the liver, with t1 / 2 of 1 to 14 hours, and the plasma protein binding rate is 95%. Most of them are metabolized in the liver, and their metabolites are 5-hydroxybuspirone and 1- (2-pyrimidinyl) -piperazine, which still have a certain biological activity. After oral administration, approximately 60% is excreted by the kidneys and 40% is excreted by feces. In liver cirrhosis, due to the reduction of the first-pass effect, the blood drug concentration can be increased, the drug clearance rate is significantly reduced, and the clearance rate is slightly reduced in renal dysfunction. There were no special changes in dynamics in elderly patients.

Storage of Buspirone Hydrochloride Tablets

Protected from light and sealed.

Packaging of Buspirone Hydrochloride Tablets

Aluminum plastic packaging, 10 pieces / board, 2 plates / box.

Expiry date of buspirone hydrochloride tablets

36 months

Buspirone hydrochloride tablet implementation standard

National Drug Standard WS1- (X-064) -2006Z ^[1]