What Is Cloxacillin Sodium?

Flucloxacillin sodium, Chinese alias is (2S, 5R, 6R) -6-[[3- (2-chloro-6-fluorophenyl) -5-methyl-1,2-oxazole-4-formyl ] Amino] -3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid sodium salt

Flucloxacillin sodium

Flucloxacillin sodium, Chinese alias is (2S, 5R, 6R) -6-[[3- (2-chloro-6-fluorophenyl) -5-methyl-1,2-oxazole-4-formyl ] Amino] -3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid sodium salt

Chinese name

Flucloxacillin sodium

Foreign name

flucloxacillin sodium

CAS number

1847-24-1

EINECS number

217-428-0

[Chinese name] Flucloxacillin sodium

[English name] flucloxacillin sodium

[English alias] Floxacillin sodium; Floxacillin Na salt; Floxapen sodium; Flucloxacillin sodium; Flucloxacillin sodium salt; MFI-PC; Monosodium flucloxacillin; NSC 277175; Sodium flucloxacillin; Stafopen sodium salt;

[CAS number] 1847-24-1

[EINECS number] 217-428-0

[Molecular formula] C19H16ClFN3NaO5S

Semi-synthetic penicillin antibiotics are mainly used for severe infection and sepsis of penicillin-resistant Staphylococcus aureus.

[Efficacy Indications] Soft tissue infections, such as abscesses, scabs, palate,

[Character] It is white or almost white crystalline powder, easily soluble in water (1: 1), soluble in ethanol (1:12), or acetone (1:12).

[Pharmacological action] This product is resistant to -lactamase produced by Staphylococcus. Intramuscular injection of the same amount of this product and clozacillin, the blood concentration of this product is significantly higher, and the effective concentration in blood is maintained for a longer time.

[Indications] Mainly used to treat severe infections of penicillin-resistant Staphylococcus aureus, as well as respiratory infections (such as acute pharyngitis, purulent tonsillitis), treatment of secondary bacterial infections of the cold, acute and chronic bronchitis, bronchitis, pneumonia, lung Abscess, empyema, osteomyelitis, septic arthritis, acute and chronic otitis media, paranasal sinusitis, periodontitis, palate, palate, erysipelas, cellulitis, tetanus, paronychia, wound and wound infections, burn infections , Urethritis, prostatitis, gonorrhea, endocarditis, gram-positive bacteria, especially septicaemia caused by Staphylococcus aureus caused by catheterization.

[Dosage and Administration] Intravenous injection and intravenous injection: 2 4g / day, divided into 2 4 injections. Dissolve in 20ml water for injection, and inject it intravenously or intravenously within 3 to 4 minutes. Intrathoracic injection: 250mg / day, dissolved in 5-10ml water for injection. Joint cavity injection: 250-500mg / day, dissolved in 5ml water for injection. Oral: 0.25 to 0.5 g / time, 4 to 6 times / day, 2 hours before meals. Children: 2 to 10 years old is half the adult dose, <2 years old is 1/4 of the adult dose.

[Precautions] Occasionally allergic reactions (such as rash), nausea, vomiting, epigastric discomfort, colitis, etc. Long-term application should check liver function. When combined infection is suspected, amoxicillin, ampicillin, ceftriazine, and ceftazidime can be used in combination. A skin test is required before use.

At present, the domestic manufacturers that have produced flucloxacillin sodium injection include: Guilin Nanyao Co., Ltd.

Instructions for Flucloxacillin Sodium Capsules

Approval Number

National Medicine Standard H20055810

Chinese name

Flucloxacillin sodium capsules

[Product English name]

Flucloxacillin Sodium Capsules

[Indications]

Soft tissue infections, such as abscesses, palate, palate, cellulitis, wound infections, burns, otitis media, skin graft protection, skin ulcers, eczema, acne, surgical preventive medications; respiratory infections, such as pneumonia, empyema, lung abscess , Sinusitis, pharyngitis, and tonsillitis; other infections, such as endocarditis, meningitis, sepsis, Neisseria infection, sepsis abortion, puerperal infection, and osteomyelitis.

chemical composition

Flucloxacillin sodium monohydrate.

[Pharmacological action]

Shijunning Jiaoxiang contains flucloxacillin sodium monohydrate equivalent to 250 mg of flucloxacillin; Shijunning powder contains flucloxacillin sodium monohydrate equivalent to 500 mg of flucloxacillin. The injection powder is dissolved in a certain amount of water for injection or 0.5% lidocaine to form a colorless transparent liquid. This drug is semi-synthetic isoxazole penicillin. It is acid-resistant penicillin. It has a protected central -lactam ring through side chain changes, which has the effect of anti-penicillinase. Penicillinase of Staphylococcus. The antibacterial spectrum of this medicine is similar to that of o-chloropenicillin. Staphylococcus aureus, Streptococcus pyogenes, Streptococcus aureus, Streptococcus pneumoniae, Bacillus anthracis, Listeria monocytogenes, Listeria monocytogenes, are resistant or sensitive to penicillin. , Corynebacterium diphtheria, Neisseria gonorrhoeae and Neisseria meningitis are effective.

medicine interactions

1 Bacteriostatic antibiotics (tetracycline and erythromycin) can fight the bactericidal effect of this medicine.

2 This medicine cannot be used in combination with colistin sodium methanesulfonate, gentamicin, kanamycin and polymyxin B.

3 Probenecid reduces renal excretion of this medicine.

4 This medicine cannot be mixed with amino acid solutions, fatty milk and blood.

Adverse reactions

1 Occasional gastrointestinal side effects such as mild and transient nausea, vomiting, and diarrhea.

2 Occasionally hepatitis and cholestatic jaundice.

3 Like other penicillins, pseudomembrane enteritis is rare.

4 Visible typical allergic reactions such as urticaria, purpura, macular rash and maculopapular rash.

5 High-dose parenteral administration can cause neurotoxicity, neutropenia, and leukocytopenia.

6 Thrombophlebitis has been observed intravenously.

Contraindications

People who are allergic to penicillin or other ingredients of this product.

[Product Specifications]

0.25g (as C19H17ClFN3O5S)

Dosage

Adults: One capsule each time, four times a day; should be taken at least half an hour before meals, severe infections, double the dose. Children's reference dosage: According to foreign species descriptions and literature records, children under 2 years old should be administered as 1/4 of the adult oral dose; 2-10 years old as the adult dose.

storage

The drug can be stored at room temperature (15-25 ° C). Validity: Capsules for 3 years.

Precautions

For chronic, recurring and severe infections or malabsorption, parenteral administration is preferred. The parenteral administration solution is best used within a few hours after the preparation of the medicinal solution. Shake well before use and inject slowly. This medicine can be added to commonly used intravenous fluids, such as normal saline, 5% glucose and 1/6 M sodium lactate. Drug rashes often occur in patients with infectious mononucleosis and lymphocytic leukemia. The combination of penicillins and cephalosporins can cause cross-allergy or cross-resistance. This drug is not suitable for subconjunctival and intrathecal injection. Occasionally, long-term use of drugs may lead to excessive growth of non-sensitive bacteria. Effects on pregnancy and lactation As far as is currently known, the use of flucloxacillin during pregnancy has not shown any danger to the fetus. Since this medicine can be secreted into milk in small amounts, there is a risk of sensitization of the baby, but this risk is small