What Is Desmopressin Acetate?

This product can shorten or normalize excessively long bleeding time during clinical invasive treatment or diagnostic surgery, or make bleeding time too long due to uremia, liver cirrhosis, congenital or drug-induced platelet dysfunction, and an unknown cause The patient's blood phenomenon was controlled. This product can be used for the control or prevention of bleeding in patients with mild hemophilia A and vascular hemophilia who have a positive test dose. For special cases, it can even be used to treat and prevent patients with moderate illness. Diabetes insipidus: 20 to 40 ug / d for adults; 10 to 20 ug / d for children, divided into 1 to 3 doses. Enuresis: 10 to 40 ug / d, used before bedtime. Renal concentration test: 40ug for adults, 10-20ug for children over 1 year old. Control bleeding or prevent bleeding before surgery: 0.3ug / kg intravenously.

Desmopressin acetate

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This product can shorten or normalize the excessively long bleeding time in clinical invasive treatment or diagnostic surgery, or cause uremic,

Drug Name: Desmopressin Acetate

English name: Desmopressin Acetate

Molecular weight: 1129.27

CAS number: 16789-98-3

Specification: 15ug / ml * 1ml * 10 sticks, 2ml * 10 sticks

category:

Control of major bleeding or prevent major bleeding before invasive surgery: 0.3ug / kg body weight, subcutaneously administered or diluted to 50-100ml with normal saline, intravenously infused within 15-30 minutes. If the effect is positive, repeat the administration 1-2 times according to the initial dose interval of 6-12 hours. Further repeated administration may reduce the effect.

Desmopressin acetate is natural ammonia salt

Fatigue, headache, nausea and stomach pain.

Excessive amounts increase the risk of water retention and hyponatremia. Management of hyponatremia varies from person to person. Patients with asymptomatic hyponatremia should discontinue desmopressin and limit fluid intake. For patients with symptomatic hyponatremia, isotonic or hypertonic sodium chloride should be added during infusion. . When water retention is severe (convulsions and unconsciousness), furazomib should be added for treatment. Habitual or mental thirst; unstable angina pectoris; metabolic dysfunction of cardiac function; patients with type IIB vascular hemophilia. Special attention should be paid to the danger of water retention. Fluid intake should be reduced to a small amount as much as possible, and body weight should be checked regularly. If body weight gradually increases, blood sodium decreases below 130mmol / L or plasma osmotic pressure is lower than 270mosm / kg, fluid intake should decrease sharply, and desmopressin should be stopped. Too young or old; diuretics are needed to treat patients with bodily fluids and / or other diseases of demature imbalance; use with caution in patients with an increased risk of intracranial pressure. Coagulation factors and bleeding time should be measured before using this drug. Plasma VIII: C and VWF: AG concentrations will increase significantly after administration, but it is not possible to establish a relationship between plasma levels of these factors and bleeding time before and after administration. relationship. Therefore, if possible, the effect of desmopressin on the bleeding time of individual patients and co-workers should be determined experimentally. The measurement of bleeding time should be standardized as much as possible, such as the Simulate II method. Effects on pregnancy and lactation. A reproductive test administered to rats and rabbits at doses more than one hundred times the human dose showed that desmopressin did not damage the embryo. One researcher has reported three cases of malformation in children with diabetes insipidus who use desmopressin during pregnancy, but other reports in more than 120 complete cases have shown that the use of past vasopressin during pregnancy Women have normal babies. In addition, a large number of data studies have shown that the rate of birth malformations of 29 babies born to pregnant women who used past vasopressin throughout the pregnancy did not increase. Analysis of the milk of lactating women who received large doses (300ug intranasally) showed that the amount of desmopressin passed to the infant was significantly lower than the amount needed to affect diuresis and hemostasis.

Preparations: Indomethacin may enhance patients' response to desmopressin, but will not prolong its duration. Some substances known to release antidiuretic hormones, such as tricyclic antidepressants, chlorpromazine and carbamazepine, enhance antidiuretic effects. Increased risk of water retention.