What Is Dextropropoxyphene?

Dextropropoxyphene is a white powder, odorless or almost odorless, and bitter. Almost insoluble in water; soluble in ethanol (1: 13-15), chloroform (1: 3-10), acetone and methanol. Also known as Daerfeng; Dextrodox; Dextropropoxyphene Napsylate; Propoxyphene. Dexpropoxyphene is similar in structure to methadone, and its hydrochloride is used clinically. Dextropropoxyphen hydrochloride is a white or slightly yellow crystalline powder, odorless and bitter. Soluble in water (1: 0.3) and ethanol (1: 1.5); soluble in acetone and chloroform; insoluble in ether, molecular formula: C22H30ClNO2, molecular weight: 375.93200. Clinically used to relieve mild to moderate pain. Combined with antipyretic and analgesics (such as acetaminophen, aspirin) to form compound tablets. ^[1-3]

Drug Name: Dexpropoxyphene
Alias: Daerfeng; Dextrodox; D-propoxyphene
Foreign name: dextropropoxyphene
Main indications: Relieves mild to moderate pain
Dosage: See below for details

Adverse reactions: Lethargy, dizziness, headache, nausea, vomiting, fatigue
Main medication contraindications: Disable allergic to dexpropoxyphene, breastfeeding children
Dosage form: Capsules, tablets
Drug type: chemical
CAS number: 469-62-5

Dexpropoxyphene Basic Information

Chinese name dexpropoxyfen

Chinese alias: acetonitrile standard sample; Daerfeng; Dextrox;

English name: dextropropoxyphene

English alias: Dextropropoxyphene;

[(2S, 3R) -4- (dimethylamino) -3-methyl-1,2-diphenylbutan-2-yl] propanoate;

Dextropropoxyphene hydrochloride;

PubChem number: 10100 ^[4]

CAS number: 469-62-5 ^[3]

Molecular formula: C22H29NO2

Molecular weight: 339.47100

Chemical Structure:

Exact mass: 339.22000

PSA: 29.54000

LogP: 4.27550 ^[3]

Dexpropoxyphene Regulatory Information

China

DEA regulated chemicals ^[3]

Physic Properties of Dexpropoxyphene

Appearance and properties: white crystalline powder

Density: 1.038 g / cm3

Melting point: 165 ± 3ºC

Boiling point: 444ºC at 760 mmHg

Flash point: 130.6ºC

Refractive index: 1.538 ^[3]

Dexpropoxyphene Safety Information

Packing level: III

Hazard category: 6.1 (b)

Dangerous Goods Transport Code: UN 3249 ^[3]

Overview of dexpropoxyphene related information

Dexpropoxyphene Drug Name

Chinese name dexpropoxyfen

English name: Dextropropoxyphene

Alias: Daerfeng; Dextrodox; Dextropropoxyphene Napsylate; Propoxyphene ^[2]

Dexpropoxyphene Classification

Nervous System Drugs> Analgesics> Strong Analgesics ^[2]

Dexpropoxyphene dosage form

1. Capsule: 32mg, 65mg;

2. Tablet: 50mg, 100mg. ^[2]

Dexpropoxyphene Pharmacological Action

Dexpropoxyphene is similar in structure to methadone. Clinical use of its hydrochloride. Dexpropoxyphene mainly binds to the opioid receptor, and its effect is similar to methadone. Its analgesic effect is weak, and it can only be used to relieve mild to moderate pain. There is almost no antitussive effect. ^[2]

Dexpropoxyphene Pharmacokinetics

It is quickly absorbed after oral administration and has a first pass effect, with a bioavailability of 30% to 70%. It is mainly excreted in the liver after being metabolized to norpropoxyphene in the liver. The apparent distribution volume is 10 ~ 26L / kg. Oral clearance is 1.3 to 3.6L per minute, and systemic clearance is 0.6 to 1.2L per minute. T 1/2 of dexpropoxyphene was 14.6 (8-24) h or 3.5-15 h; t1 / 2 of metabolite norpropoxyphenol was 22.9 h. ^[2]

Dexpropoxyphene indications

Used to relieve mild to moderate pain. Combined with antipyretic and analgesics (such as acetaminophen, aspirin) to form compound tablets. ^[2]

Deoxypropoxyphene Contraindications

Those who are allergic to dexpropoxyphene and breastfeeding children are prohibited. ^[2]

Dexpropoxyphene precautions

1. Patients with liver and kidney dysfunction should be used with caution; 2. Not for injection. ^[2]

3. Pay attention to any signs of poisoning during medication. ^[2]

Dexpropoxyphene adverse reactions

1. Drowsiness, dizziness, headache, nausea, vomiting, and fatigue can occur.

2. Abuse can produce physical and mental dependence.

3. Less common are constipation, abdominal pain, rash, headache, occasionally weakness, euphoria, dysphonia, and mild visual impairment.

4. Excessive poisoning and manifestations of respiratory depression, extreme drowsiness and fatigue, followed by coma, pupil reduction, local or general twitching, abnormal cardiac conduction, arrhythmia, pulmonary edema, and even apnea and cardiac arrest. There have been reports of overdose, which is related to the accumulation of norpropoxyphene. Ethanol and other central inhibitors can exacerbate excess poisoning. ^[2]

5. Intravenous injection can cause toxic psychosis. ^[2]

Dexpropoxyphene dosage

For chronic rheumatoid arthritis, migraine, etc. Each oral administration of 65mg of hydrochloride or 100mg of naphthalenesulfonate can be repeated for 4-6 hours. ^[2]

Interaction of Dexpropoxyphene with Other Drugs

1. Combined with other central nervous system inhibitors such as ethanol, sedative hypnotics, anxiolytic and analgesics, can enhance the effects of these drugs, and has been reported to be fatal. ^[2]

2. Can enhance the anticoagulant effect of oral anticoagulant warfarin.

3. Aspirin and acetaminophen can enhance the analgesic effect of dexpropoxyphene. ^[2]

4. Naloxone can counteract the respiratory depression of dexpropoxyphene. ^[2]