What Is Dispersible Aspirin?

Aspirin dispersible tablets, 1. Analgesia and antipyretic: relieve mild or moderate pain, such as headache, toothache, neuralgia, muscle pain, and menstrual pain. It is also used for antipyretics such as colds and flu. This product can only relieve symptoms and cannot treat the pain and The cause of fever, so other drugs should be used to treat the cause. 2. Anti-inflammatory, anti-rheumatic: commonly used drugs for the treatment of rheumatic fever. After treatment, it can relieve fever, relieve joint pain and other symptoms, and reduce erythrocyte sedimentation, but it cannot change the basic pathological changes of rheumatic fever, nor can it treat and prevent rheumatic heart damage and other complications. 3 Arthritis: In addition to rheumatoid arthritis. This product is also used to treat rheumatoid arthritis, which can improve symptoms, but it must be treated with the cause. In addition, this product is also used in osteoarthritis, ankylosing spondylitis, gouty arthritis, juvenile arthritis and other non-rheumatic inflammation of musculoskeletal pain, which can also relieve symptoms. But in recent years, this product has been rarely used. 4 Antithrombotic: This product has an inhibitory effect on platelet aggregation and can prevent thrombosis. It is clinically used to prevent transient ischemic attacks, myocardial infarction, atrial fibrillation, artificial heart valves, arteriovenous fistulas or other postoperative thrombosis. Can also be used to treat unstable angina. 5. Skin and mucosal lymph node syndrome (Kawasaki disease) in children. ^[1] .

Drug Name: Aspirin dispersible tablets
Hanyu Pinyin: A Si Pi Lin Fen San Pian

Drug type: Work Injury Medical Insurance Class A Double Span
Use classification: Anti-migraine drugs

Aspirin dispersible tablets ingredients

aspirin.

Aspirin scattered tablets

This product is a white tablet.

Aspirin dispersible tablets indications

1. Analgesia and antipyretic: relieve mild or moderate pain, such as headache, toothache, neuralgia, muscle pain, and menstrual pain. It is also used for antipyretics such as colds and flu. This product can only relieve symptoms and cannot treat the pain and The cause of fever, so other drugs should be used to treat the cause.
2. Anti-inflammatory, anti-rheumatic: commonly used drugs for the treatment of rheumatic fever. After treatment, it can relieve fever, relieve joint pain and other symptoms, and reduce erythrocyte sedimentation, but it cannot change the basic pathological changes of rheumatic fever, nor can it treat and prevent rheumatic heart damage and other complications.
3 Arthritis: In addition to rheumatoid arthritis. This product is also used to treat rheumatoid arthritis, which can improve symptoms, but it must be treated with the cause. In addition, this product is also used in osteoarthritis, ankylosing spondylitis, gouty arthritis, juvenile arthritis and other non-rheumatic inflammation of musculoskeletal pain, which can also relieve symptoms. But in recent years, this product has been rarely used.
4 Antithrombotic: This product has an inhibitory effect on platelet aggregation and can prevent thrombosis. It is clinically used to prevent transient ischemic attacks, myocardial infarction, atrial fibrillation, artificial heart valves, arteriovenous fistulas or other postoperative thrombosis. Can also be used to treat unstable angina.
5. Skin and mucosal lymph node syndrome (Kawasaki disease) in children.

Aspirin dispersible tablets specifications

50mg

Aspirin dispersible tablets

1. Adults usually take it orally.
(1) Antipyretic and analgesic: 0.3 ~ 0.6g once, 3 times a day, and once every 4 hours if necessary.
(2) Anti-inflammatory and anti-rheumatic: 3-6g a day, orally in 4 times.
(3) Inhibition of platelet aggregation: low-dose application.
Ischemic stroke and transient ischemic attack to prevent the occurrence of myocardial infarction, unstable angina pectoris, chronic stable angina pectoris, once 50 to 300 mg, once a day;
For acute myocardial infarction, the initial dose is 300 mg, and the maintenance dose is 50 to 100 mg per day;
Coronary Artery Bypass Grafting (CABG), 300 mg daily, can begin 6 hours after surgery;
Percutaneous transluminal coronary angioplasty (PTCA), an initial dose of 300 mg is given 2 hours before the operation, and the maintenance dose is 50 mg to 100 mg daily;
Carotid endarterectomy, it is recommended to start before surgery, once 100mg ~ 300mg once a day.
(4) Biliary tsutsugamushi: Take 1g orally once, 2 to 3 times a day, and then use it for 2 to 3 days. After paroxysmal colic is stopped for 24 hours, stop using it, and then perform deworming treatment.
2. Commonly used in children.
(1) Antipyretic and analgesic: Take oral body surface area 1.5g / m ^[2] daily orally 4 to 6 times, or each time according to body weight 5-10mg / kg, or 60mg per year, if necessary Once every 4 to 6 hours.
(2) Anti-rheumatic: Take a dose of 80 to 100 mg / kg daily, divided into 3 to 4 times. If no effect is obtained in 1 to 2 weeks, the dose can be adjusted according to the blood concentration. In some cases it is necessary to increase to 130 mg / kg daily.
(3) Pediatric cutaneous mucosal lymph node syndrome (Kawasaki disease): Start with daily weight of 80 to 100 mg / kg, 3 to 4 times a day; 2 to 3 days after fever reduction, change to 30 mg / kg, 3 to 3 4 times; reduce the dose to 3 ~ 5mg / kg once a day after the symptoms are relieved, once a day for 2 months or longer.

Aspirin dispersible tablets adverse reactions

The dosage generally used for antipyretic analgesia rarely causes adverse reactions. A large number of long-term medication (treatment of rheumatic fever), especially when the blood concentration of the drug is> 200 g / ml, adverse reactions are more likely to occur. The higher the blood concentration, the more obvious the adverse reactions.
1. Central nervous system: Reversible tinnitus and hearing loss occur, mostly after taking a certain course of treatment, and the blood concentration reaches 200-300 g ml.
2. Allergic reactions: In 0.2% of patients, asthma, urticaria, angioedema, or shock. Most of them are susceptible. Breathing difficulties occur quickly after taking the medicine, and severe cases can cause death, which is called aspirin asthma. Some are aspirin allergies, asthma, and triad of nasal polyps, often associated with genetic and environmental factors.
3 Damage to liver and kidney functions is related to the size of the dose, especially when the blood concentration of the ambassador exceeds 250 g / ml. The damage is reversible and can be recovered after stopping the drug, but it has been reported to cause renal papillary necrosis.

Aspirin dispersible tablets contraindications

The following conditions should be disabled:
1. Gastrointestinal bleeding due to active ulcers or other causes;
2. Hemophilia or thrombocytopenia;
3 People with allergies to aspirin or other non-steroidal anti-inflammatory drugs, especially those with asthma, neurovascular edema, or shock.

Precautions for aspirin dispersible tablets

1. Cross-allergic reactions. Allergic to this product may also be allergic to another non-steroidal anti-inflammatory drug. But not absolutely, you must be alert to the possibility of cross-allergies.
2. Interference to diagnosis:
(1) When the long-term daily dosage exceeds 2.4g, the copper sulfate urine glucose test may appear false positive, and the glucose enzyme urine glucose test may appear false negative;
(2) Can interfere with urine ketone test;
(3) When the blood drug concentration exceeds 130 g ml, the false high value can be obtained by measuring the blood uric acid with the colorimetric method, but the urase method is not affected;
(4) It can be interfered by this product when measuring 5-hydroxyindoleacetic acid (5-HIAA) by fluorescence method;
(5) The determination of urine vanillyl mandelic acid (VMA) can be high or low due to different methods used;
(6) As this product inhibits platelet aggregation, it can prolong bleeding time. Dose as small as 40mg / day can also affect platelet function, but there have been no clinical reports of small doses (<150mg / day) causing bleeding;
(7) In liver function tests, when the blood drug concentration is> 250 g / ml, alanine aminotransferase, aspartate aminotransferase, and serum alkaline phosphatase may be abnormally changed, and normalized when the dose is reduced.
(8) For large-dose applications, especially when the blood concentration is> 300 g / ml, the prothrombin time can be prolonged;
(9) Serum cholesterol can be reduced when the daily dosage exceeds 5g;
(10) As this product acts on the renal tubules, the potassium excretion increases, which can lead to a decrease in blood potassium;
(11) When this product is applied in large doses, lower results can be obtained by measuring serum thyroxine (T ₄ ) and triiodothyronine (T ₃ ) by radioimmunoassay;
(12) Due to the competitive excretion of this product with phenolsulfophthalein in the renal tubules, the excretion of phenolsulfophthalein is reduced (ie, the PSP excretion test).
3 The following situations should be used with caution:
(1) When having asthma and other allergic reactions:

(2) Those with glucose-6-phosphate dehydrogenase deficiency (this product occasionally causes hemolytic anemia);
(3) Gout (this product can affect the effect of uric acid medicine, which may cause uric acid retention at low doses);
(4) Hepatic dysfunction can aggravate liver toxic reactions and aggravate bleeding tendency. Patients with liver dysfunction and cirrhosis are prone to kidney adverse reactions;
(5) Cardiac insufficiency or hypertension. May cause heart failure or pulmonary edema when used in large amounts;
(6) Risk of aggravating renal toxicity during renal insufficiency;
(7) Those with thrombocytopenia.
4 Regular long-term use of drugs should be checked for hematocrit, liver function and serum salicylic acid content.

Aspirin dispersible tablets for pregnant and lactating women

Try to avoid it.
1. This product easily passes through the placenta. Animal test application of this product in the first 3 months of pregnancy can cause teratomy, such as spina bifida, skull fissure, facial fissure, leg deformities, and central nervous system, visceral and skeletal hypoplasia. There are also reports of fetal defects in humans after application of this product. In addition, long-term large-scale application of this product in the 3 months after pregnancy can prolong the pregnancy and increase the risk of postpartum syndrome and prenatal bleeding. Application in the last 2 weeks of pregnancy can increase the risk of fetal bleeding or neonatal bleeding. Long-term use in late pregnancy may also cause fetal arterial ducts to contract or lock up early, leading to persistent pulmonary hypertension and heart failure in the newborn. It has been reported that overdose or abuse of this product in late pregnancy increases the incidence of stillbirths or neonatal deaths (possibly due to blocked arterial ducts, prenatal bleeding, or underweight). However, the above-mentioned adverse reactions have not been found with the general therapeutic dose.
2. This product can be excreted in breast milk. Breastfeeding women take 650 mg orally. After 5 to 8 hours, the drug concentration in breast milk can reach 173 to 483 g / ml, so infants may have adverse reactions during long-term high-dose administration.

Aspirin dispersible tablets for children

Try to avoid it. Pediatric patients, especially those with fever and dehydration, are prone to toxic reactions. Acute febrile diseases, especially children with influenza and chickenpox, may be related to Reye's Syndrome, which can cause death in severe cases, which is rare in China.

Aspirin dispersible tablets for the elderly

Elderly patients are prone to toxic reactions when taking this product due to the decline in renal function.

Aspirin dispersible tablets drug interactions

1. The effect is not enhanced when used with other non-steroidal anti-inflammatory drugs, because this product can reduce the bioavailability of other non-steroidal anti-inflammatory drugs. This product is used together with acetaminophen for a long time, and it may cause kidney diseases including renal papillary necrosis, kidney cancer or bladder cancer.
2. When used with any drug that can cause hypothrombinemia, thrombocytopenia, reduced platelet aggregation, or gastrointestinal ulcer bleeding, there may be a risk of aggravating coagulopathy and causing bleeding.
3. Used together with anticoagulants (dicoumarin, heparin, etc.) and thrombolytic drugs (streptokinase, urokinase), can increase the risk of bleeding.
4 Urine alkalizing drugs (sodium bicarbonate, etc.) and antacids (large-scale long-term application) can increase the excretion of this product from the urine and reduce the blood concentration. But when the blood solubility of this product has reached a steady state, alkaline drugs are discontinued. It can also increase the blood concentration of this product to toxic levels. Carbonic anhydrase inhibitors can make urine alkaline, but can cause metabolic acidosis, which not only can reduce the blood concentration, but also increase the amount of this product penetrated into the brain tissue, thereby increasing the toxicity.
5. Uric acidification drug can reduce the excretion of this product and increase its blood concentration. Patients whose blood concentration has reached a stable state may increase the blood concentration of this product and increase the toxic reaction.
6. Glucocorticoids (hormones for short) can increase salicylate excretion. In order to maintain the blood concentration of this product, the dosage of this product should be increased when necessary. This product has been used together with hormones for a long time, especially when it is used in large quantities, which increases the risk of gastrointestinal ulcers and bleeding. For this reason, the simultaneous application of these two drugs is not advocated in clinical practice.
7. The hypoglycemic effect of insulin or oral hypoglycemic drugs can be strengthened and accelerated by the same use with this product.
8. When used with methotrexate (MTX), it can reduce the combination of methotrexate and protein, reduce its excretion from the kidney, increase the blood concentration and increase the toxicity.
9. The uric acid effect of probenecid or sulfinpyrazone can be reduced by the simultaneous application of this product; when the salicylate blood concentration is> 50 g / ml, it is significantly reduced, and more than 100 to 150 g / ml very. In addition, probenecid can reduce salicylate clearance from the kidneys, thereby increasing the plasma concentration of the latter.

Aspirin dispersible tablets overdose

Overdose or poisoning:
1. Mild, that is, salicylism, is more common in rheumatoid patients treated with this product, and manifests as headache, dizziness, tinnitus, deafness, nausea, vomiting, diarrhea, drowsiness, mental disorders, sweating, deep breathing, Thirst, involuntary movements of hands and feet (most common in the elderly), and visual impairment;
2. Severe, hematuria, convulsions, hallucinations, severe mental disorders, dyspnea, and unknown fever may occur; children with mental and respiratory disorders are more obvious; laboratory tests may have abnormal EEG, acid-base balance changes (respiratory bases) Poisoning and metabolic acidosis), hypoglycemia or hyperglycemia, ketonuria, hyponatremia, hypokalemia, and proteinuria. Handling: Rescue as usual.

Pharmacology and Toxicology of Aspirin Dispersible Tablets

This product is a non-steroidal anti-inflammatory drug.
1. Analgesic effect: It is mainly by inhibiting the synthesis of prostaglandins and other substances (such as bradykinin, histamine) that can make pain sensitive to mechanical or chemical stimuli, and belongs to peripheral analgesics. However, the possibility of central analgesia (which may act on the hypothalamus) cannot be ruled out;
2. Anti-inflammatory effect; the exact mechanism is not clear, it may be due to the effect of this product on inflammatory tissues, by inhibiting the synthesis of prostaglandins or other substances that can cause inflammatory reactions (such as histamine) and play an anti-inflammatory effect. Inhibition of lysosomal enzyme release and leukocyte chemotaxis may also be related to it;
3 Antipyretic effect: It may cause peripheral blood vessel dilatation, increase skin blood flow, sweat, and increase heat dissipation by acting on the hypothalamus thermoregulatory center. This central effect may be related to the inhibition of prostaglandin synthesis in the hypothalamus;
4 Anti-rheumatic effect: The anti-rheumatic mechanism of this product is mainly anti-inflammatory except for antipyretic and analgesic effects;
5. Inhibition of platelet aggregation: It works by inhibiting platelet cyclooxygenase and reducing the production of prostaglandins.

Pharmacokinetics of Aspirin Dispersible Tablets

After absorption of this product, most of it is hydrolyzed into salicylic acid in the liver. Salicylic acid has a plasma protein binding rate of 65% to 90%. The salicylate binding rate is 65% to 90%. Can be distributed in all tissues of the body, can also penetrate into the joint cavity and cerebrospinal fluid. Salicylic acid is metabolized to a combination of salicylic acid and glucuronic acid, and a small part is oxidized to gentisic acid. Free salicylic acid and bound metabolites are excreted from the kidneys. Excreted faster in alkaline urine; also excreted through milk.