What Is Fusidic Acid?
Fusidic acid is highly sensitive to various Gram-positive cocci related to skin infections, especially to staphylococci. It is also effective against drug-resistant Staphylococcus aureus, and it also has certain antibacterial effects on certain Gram-negative bacteria. No cross-resistance with other antibiotics.
- Drug Name
- Fusidic acid
- Foreign name
- Fusidic Acid
- Drug type
- Antibiotics
- Fusidic acid is highly sensitive to various Gram-positive cocci related to skin infections, especially to staphylococci. It is also effective against drug-resistant Staphylococcus aureus, and it also has certain antibacterial effects on certain Gram-negative bacteria. No cross-resistance with other antibiotics.
Fusidic Acid Basic Information
- Chinese name
- Chinese alias: brown mold acid
- English name: Fusic acid
- English alias: Fusidate sodium; Diethanolamine fusidate; FUCIDIN; fusdic acid; (2Z) -2-[(3R, 4S, 5S, 8S, 9S, 10S, 11R, 13R, 14S, 16S) -16-acetyloxy-3,11 -dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta [a] phenanthren-17-ylidene ] -6-methylhept-5-enoic acid; Fucidin acid; Ramycin; Fucidic acid; FusidicAcid; Fusidine; Fusidate; Fucithalmic;
- CAS number: 6990-06-3
- Molecular formula: C 31 H 48 O 6
- Molecular weight: 516.70900
- Exact mass: 516.34500
- PSA: 104.06000
- LogP: 5.66610
- Physical and chemical properties
- Appearance and properties: white solid
- Density: 1.16g / cm 3
- Melting point: 190-192ºC
- Boiling point: 635ºC
- Refractive index: 1.558
- Storage conditions: 2-8ºC [1]
Fusidic acid Fusidic acid related drug label information
Fusidic acid pharmacological action
- This product is an antibiotic with a steroid skeleton that inhibits protein synthesis by bacteria. And antibacterial or bactericidal effect. It has strong antibacterial effect on staphylococci (including methicillin-resistant strains or other antibiotic-resistant strains), and it also has certain antibacterial effects on streptococcus, enterococcus, diphtheria, clostridium, Neisseria, and tuberculosis. Effect, weaker on B. fragile.
- Pharmacokinetics
- Oral absorption is easy, taking 0.5g on an empty stomach, blood concentration can reach 30g / ml in 2 ~ 3h; repeated administration once every 8 hours for 4 consecutive days, blood concentration can reach 50 ~ 100g / ml. The blood concentration after taking sodium salt is higher than taking free acid. It is widely distributed in the body, but it is not easy to penetrate the blood-cerebrospinal fluid barrier. Trace drugs can only be seen during meningitis inflammation, but it can enter the fetal circulation or enter milk. The plasma half-life is 5-6 hours, and the plasma protein binding rate is as high as 97%. This product is metabolized in the body and is mainly concentrated and excreted by bile. Kidney excretion is minimal (less than 1%).
- Dosage form and specifications
- Tablet: 250mg.
Fusidic acid indication
- For drug-resistant Staphylococcus aureus infections, such as pneumonia, osteomyelitis, and sepsis. Severe patients need intravenous administration and should be used in combination with other anti-staphylococcal drugs. Topical treatment of skin and wound infections.
Fusidic acid contraindications
- Liver and kidney dysfunction is disabled.
Fusidic acid notes
- Use with caution in pregnant and lactating women.
Fusidic acid adverse reactions
- Common mild gastrointestinal reactions. Occasionally rash, cholestatic jaundice, liver function changes and intravenous injection can cause phlebitis.
Fusidic acid dosage
- Oral: 1. 0.5g each time, once every 8 hours, can be doubled for severe infections; children under 2.1 years of age 50mg / kg, divided into 2 to 3 times; 3.1 to 5 years old, 0.25g each time, 3 times a day. 4.5 to 12 years old can be given as an adult [2] .