What Is Hydroxyzine?

Hydroxyzine is a piperazine compound. It is a non-BDZ anxiolytic drug. It has a mild effect, has sedative, weak stability and muscle relaxation effects, and has antihistamine effect. Oral or intramuscular injection can be quickly absorbed and quickly distributed. It is effective when taken orally for 1 hour, and the elimination half-life is: 7 to 10 hours for adults, 6 to 7 hours for children, and 18 to 21 hours or longer for the elderly and renal insufficiency. Metabolized mainly by the liver. This product mainly passes through the liver and intestines and is finally excreted through feces.

Basic Information

Chinese name

Hydroxazine

Foreign name

Hydroxyzine

Chinese pronunciation

qingqín

CAS NO.

68-88-2

Hydroxazine indication

It is suitable for mild anxiety, nervousness, agitation and other mental states and neurosis. It can also be used for vomiting, sedation before surgery, urticaria and allergic diseases.

Clinical application of hydroxyzine

Oral: anti-anxiety, nervousness, anti-allergy: 25-50mg per adult, 3 times a day; sedation before surgery: 50-100mg per adult. intramuscular injection: 100 ~ 200mg each time.

Hydroxazine adverse reactions

Adverse reactions can include drowsiness, headache, itching, occasional thirst, constipation, and weakness; larger doses can cause dyskinesia, restlessness, tremor, and spasm.

Hydroxazine precautions

Long-term use can create dependencies. Leukopenia, epilepsy, allergic to this product, pregnant and lactating women, infants are prohibited. Use with caution in patients with liver and kidney dysfunction and those with pulmonary dysfunction. Liver function and white blood cell count should be checked regularly. It is not advisable to drive vehicles, operate machinery or work at height during medication. Do not drink alcohol while taking the medicine. Children under 6 years should be used with caution, the daily dose should not exceed 50mg. In combination with central nervous system inhibitors, opioid analgesics, and barbiturates, the effect of combined drugs is enhanced. This product is used in combination with ketamine, the anesthesia recovery time of the latter is extended by 30% to 40%.

(Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.)