What Is Ibuprofen Toxicity?

Ibuprofen is an antipyretic and analgesic, non-steroidal anti-inflammatory drug. This product inhibits cyclooxygenase, reduces prostaglandin synthesis, produces analgesic and anti-inflammatory effects, and acts as an antipyretic by regulating the center of hypothalamic body temperature.

Chinese name: Ibuprofen
Foreign name: Ibuprofen

Molecular formula: C13H18O2
Other name: Rage, Ibuprofen
CAS: 15687-27-1

Ibuprofen indication

Used to relieve mild to moderate pain such as headache, arthralgia, migraine, toothache, muscle pain, neuralgia, dysmenorrhea. It is also used for fever caused by common cold or influenza.

Clinical application of ibuprofen

Anti-rheumatic, oral: 0.4 to 0.6 g / time, 3 to 4 times / day.

For acute mild and moderate pain and fever, 0.2 to 0.4 g / time, once every 4 to 6 hours, the maximum limit is 2.4 g / day. Sustained-release capsules: 0.3-0.6 g / time for adults and children over 12 years, 2 times / day.

Ibuprofen adverse reactions

1. 16% of long-term users may have gastrointestinal adverse reactions, including indigestion, burning sensation, stomach pain, nausea, and vomiting. Generally, it is not necessary to stop the drug and continue to take it. Gastric ulcers and gastrointestinal bleeding occurred in less than 1%.

2. 1% to 3% of patients may experience neurological reactions such as headache, drowsiness, dizziness, and tinnitus.

3. Rare side effects include lower extremity edema, renal insufficiency, rash, bronchial asthma, abnormal liver function, and leukopenia.

Ibuprofen notes

Gastrointestinal reactions are the most common adverse reactions, with bone marrow suppression and liver function damage at high doses. Severe liver and kidney dysfunction or severe heart failure are contraindicated.

Ibuprofen contraindications

People who are allergic to aspirin or other non-steroidal anti-inflammatory drugs may have a cross-allergic reaction to this product and it is prohibited. Patients with active or previous history of peptic ulcer, gastrointestinal bleeding or perforation are contraindicated. Banned for pregnant and lactating women.

Ibuprofen drug interactions

1. When used with heparin and oral anticoagulants, there is a risk of increased bleeding.

2. When used with furosemide, the hypotensive effect of the latter is weakened.

3. When used with verapamil, nifedipine, probenecid, the blood concentration of ibuprofen increases.

4. Enhance the effect or increase the toxicity of methotrexate, digoxin, and hypoglycemic agents.

Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.