What Is Ipratropium Bromide?
[(1R, 5S) -8-methyl-8-isopropyl-8-azabicyclo [3.2.1] oct-3-yl] 3-hydroxy-2-phenylpropionate bromide
- Ipratropium bromide is used to relieve bronchospasm and wheezing caused by chronic obstructive pulmonary disease (COPD). Prevention and treatment of asthma, especially suitable for patients who cannot tolerate such drugs due to muscle tremor and tachycardia caused by beta receptor agonists.
- Drug name
- Ipratropium bromide
- Drug type
- Essential medicines
- English name
- Ipratropium Bromide
- Chinese alias
- Ipratropium bromide; Ipratropium bromide; Ipratropine
- English alias
- Actovent Nounosecretol; ScH1000; Isopropyl Atropine Brom
Ipratropium bromide chemical name
- [(1R, 5S) -8-methyl-8-isopropyl-8-azabicyclo [3.2.1] oct-3-yl] 3-hydroxy-2-phenylpropionate bromide
Ipratropium bromide molecular structure
Ipratropium bromide molecular formula
- C20H30BrNO3
Ipratropium bromide molecular weight
- 412
Physical and Chemical Properties of Ipratropium Bromide
- Its bromide is commonly used as a white crystalline powder with a bitter taste. Soluble in water, slightly soluble in ethanol, insoluble in other organic solvents. Melting point: 232 ~ 233 ° C.
Ipratropium bromide pharmacology
- It is a potent anticholinergic drug with high selectivity for bronchial smooth muscle M receptors. It has a strong effect on bronchial smooth muscle relaxation and a weak effect on the respiratory glands and the cardiovascular system. The dose of bronchiectasis is only 1/20 to 1/10 of the dose to inhibit glandular secretion and accelerate heart rate. The effect of aerosol inhalation of 40g or 80g on asthma patients is equivalent to the effect of aerosol inhalation of 2mg atropine, 70-200g isoprenaline or 200g albuterol. Neither the sputum volume nor the viscosity of sputum changed significantly after administration, but foreign reports have suggested that this product can promote the movement of cilia of the bronchial mucosa, which is conducive to sputum excretion. This product is a quaternary ammonium salt and should not be absorbed orally. The effect comes about 5 minutes after aerosol inhalation, and the effect reaches a peak in about 30 to 60 minutes, maintaining for 4 to 6 hours.
Ipratropium bromide indications
- It is used to relieve the symptoms of bronchospasm and wheezing caused by chronic obstructive pulmonary disease (COPD). Prevention and treatment of asthma, especially suitable for patients who cannot tolerate such drugs due to muscle tremor and tachycardia caused by beta receptor agonists.
Ipratropium bromide usage and dosage
- Due to different dosage forms and specifications, please read the drug instructions carefully or follow the doctor's advice.
Ipratropium bromide adverse reactions
- Dry mouth, headache, dry nasal mucosa, cough, and tremor are common. Occasionally, palpitations, bronchospasm, dry eyes, eye conditioning disorders, and urinary retention. Rarely allergic reactions.
Ipratropium bromide contraindications
- Prohibited in those who are allergic to this product and atropine drugs. Pyloric obstruction.
Ipratropium bromide precautions
- Use with caution in patients with glaucoma and benign prostatic hyperplasia. Avoid inhaling medicine into the eyes when inhaling. In patients with narrow-angle glaucoma, the combination of this product and -receptor agonist can increase the risk of acute attack of glaucoma. When using the compound preparation composed of -agonist, pay attention to the contraindications of both.
Ipratropium bromide drug interactions
- Combination with -receptor agonists (albuterol, fenoterol), theophylline, and sodium cromoglycate can mutually enhance the curative effect. Amantadine, phenothiazine antipsychotics, tricyclic antidepressants, monoamine oxidase inhibitors and antihistamines can enhance the effect of this product.
Ipratropium bromide
- Aerosol: 14g: 8.4mg (40g per )
Ipratropium Bromide Introduction
- [Identification] (1) The identification response of tropane alkaloids in this product (Appendix III of Part Two of Chinese Pharmacopoeia 2000 Edition). (2) This product is an identification reaction of aqueous chloride (Chinese Pharmacopoeia 2000 Edition, Appendix II). (3) The infrared light absorption spectrum of this product should be the same as that of the ipratropium bromide reference substance (Chinese Pharmacopoeia 2000 Version II Appendix IV C). [Inspection] Take 0.20g of this product, dissolve it by adding 20ml of water, and measure it according to law (Chinese Pharmacopoeia 2000 Edition Two Appendix VI H). The pH value should be 5.0 7.5. Clarity and color of the solution: Take 0.20g of this product, add 20ml of water and shake to dissolve. The solution should be clear and colorless. If it is turbid, it should not be more concentrated than the turbidity standard solution No. 1 (Appendix VIII B of Part Two of the Chinese Pharmacopoeia 2000 Edition). Relevant substances are taken from this product, dissolved in methanol to make a solution containing 10mg per 1ml, as a test solution: another appropriate amount of tropinic acid N-isopropylnortropine ester reference substance, and chloroform to make each 1ml The solution containing 0.1mg was used as the reference solution. According to the thin layer chromatography (Chinese Pharmacopoeia 2000 edition, Appendix VB) test, draw 10 ml of each of the two solutions, and point them on the same alumina G thin layer plate with sodium carboxymethyl cellulose solution as the binder. The methyl ethyl ketone-methanol-concentrated ammonia solution (5: 2: 0.2) is used as a developing agent. After the developing, it is allowed to dry, and after being developed in iodine vapor, it is inspected immediately. The color of the test solution, such as a spot of impurities, must not be darker than the main spot of the reference solution (1%). Loss on drying: Take this product and dry to constant weight at 105 ° C. Loss of weight should not exceed 0.5% (Chinese Pharmacopoeia 2000 Edition, Appendix II VIII L). The burning residue shall not exceed 0.1% (Appendix VIII N of the Second Part of Chinese Pharmacopoeia 2000 Edition). Take 1.0g of this product for heavy metals and check it according to law (the first method of Appendix VIII H of the Second Part of Chinese Pharmacopoeia 2000 Edition). The content of heavy metals must not exceed 20 parts per million. [Content determination] Take about 0.2g of this product, accurately weigh, add 20ml of glacial acetic acid, heat slightly to dissolve, let cool, add 4ml of mercury acetate test solution and 1 drop of crystal violet indicator solution, use perchloric acid 0.1 mol / L) titration to blue-green, and the titration results were corrected with a blank test. Each 1ml of perchloric acid titration solution (0.1mol / L) is equivalent to 41.24mg of C20H30BrNO3. [Category] Anticholinergics.