What is Kanamycin Resistance?
Kanamycin is an antibiotic that kills certain types of bacteria. Bacteria multiply rapidly and are capable of fast mutations that can produce new bacteria that are not vulnerable to antibiotics. In the case of canamcin resistance, this problem deteriorates because bacterial resistance to related antibiotics can also provide some resistance to canamycin.
Aminoglycoside group Antibiotics includes canamycin and substances such as gentamicin and streptomycin. This group of antibiotics attacks a wide range of bacterial pathogens. Their way of action is to disrupt the synthesis of the protein of the bacterial cell. They do this by sticking to structures known as ribosome 30 years. Years that help build protein springs.
Ribosome blocking 30s prevents the bacteria in the production of proteins it needs to survive and growth. It also causes the cell to spend energy producing proteins that are not useful. Kanamycin also makes cell membrane less robust, which is harmful to bacteriai. Bacteria
multiply very quickly and can be present in large numbers. The bacteria population may vary in genetic make -up and therefore in potential targets for antibiotics. If the infected person accepts an antibiotic, this medicine may kill all receptive bacteria and let the bacteria behind it has special resistance to this antibiotics. These can then grow again from control and be immune to the same antibiotics.
Examples of bacterial infections that could be treated with kanamycin include Escherichia coli, serratia Marcescens, and mycobacterium tuberculosis . In the case of tuberculosis, which is commonly resistant to several drugs, canamin is the treatment of the second line and is prescribed only after the initial treatment failure. It is usually taken in combination with other medicines to increase efficiency if the pathogen has canam resistance.
genes and mutations are reasonsResistance to Kanamycin. Bacteria can be naturally resistant to the drug. One such example is the NPTII gene, which naturally occurs in bacteria and produces an enzyme that inhibits the action of canamin in a bacterial cell. This type of natural resistance passes through bacterial generations.
various bacteria can also obtain a gene resistance to kanamycin in a horizontal way. The bacterial virus that previously infected one cell can randomly pick up the gene from this cell and transfer it to another cell. Bacteria can also provide small packages of genetic material in small DNA circles known as plasmids. Sometimes the cell simply lifts free genes from broken cells in the environment.