What Is Mebeverine Hydrochloride?

Mebeverine Hydrochloride Chemical Name 4- [ethyl- [1- (4-methoxyphenyl) prop-2-yl] amino] butyl 3,4-dimethoxybenzoyl Ester hydrochloride, molecular formula is C25H36ClNO5, molecular weight is 466.01000, melting point is 105-107ºC, boiling point is 543.8ºC at 760mmHg, stored at 2-8ºC.

Mebeverine Hydrochloride Chemical Name 4- [ethyl- [1- (4-methoxyphenyl) prop-2-yl] amino] butyl 3,4-dimethoxybenzoyl Ester hydrochloride, molecular formula is C25H36ClNO5, molecular weight is 466.01000, melting point is 105-107ºC, boiling point is 543.8ºC at 760mmHg, stored at 2-8ºC.

Chinese name

Mebeverine hydrochloride

Foreign name

MebeverineHydrochloride

CAS number

2753-45-9

Molecular formula

C25H36ClNO5

Molecular weight

466.01000

Brief introduction of mebeverine hydrochloride compounds

Basic information of mebeverine hydrochloride

Chinese name: mebeverine hydrochloride

Chinese alias: Maipifanlin hydrochloride; mebeverine hydrochloride; 4- [ethyl- [1- (4-methoxyphenyl) prop-2-yl] amino] butyl 3,4-di Methoxybenzoate hydrochloride;

English name: Mebeverine Hydrochloride

English alias:

Mebeverine hydrochloride; 4- [ethyl- [1- (4-methoxyphenyl) propan-2-yl] amino] butyl 3,4-dimethoxybenzoate, hydrochloride; MebeverineHydrochloride;

CAS number: 2754-45-9

Molecular formula: C ₂₅ H ₃₆ ClNO ₅

Molecular weight: 466.01000

Structural formula:

Exact mass: 465.22800

PSA: 57.23000

LogP: 5.40450 ^[1]

Physical and chemical properties of mebeverine hydrochloride

Melting point: 105-107ºC

Boiling point: 543.8ºC at 760mmHg

Flash point: 282.7ºC

Storage conditions: 2-8ºC

Vapor pressure: 6.92E-12mmHg at 25 ° C ^[1]

Pharmacology and toxicology of mebeverine hydrochloride

This product is a pro-myogenic antispasmodic drug that directly acts on the smooth muscles of the gastrointestinal tract to relieve the symptoms of spasm without affecting normal bowel movements. This effect does not pass through the autonomic nervous system, so there is no anticholinergic effect, so this product is also suitable for patients with prostatic hypertrophy and glaucoma ^[2]

Pharmacokinetics of mebeverine hydrochloride

Mebeverine hydrochloride is rapidly and completely absorbed in the duodenum after oral administration. The protein binding rate was 76%. Complete metabolism in the body, the metabolites are veratronic acid and mebeverin hydrochloride, of which mebeverin hydrochloride can be further metabolized into carboxylic acid and demethylated carboxylic acid. 95% to 98% of the oral dose is excreted from the urine by the kidney within 8 hours in the form of metabolites, and there is no prototype drug in the urine. ^[2]

Mebeverine hydrochloride indications

Symptomatic treatment of abdominal cramps caused by irritable bowel syndrome, intestinal dysfunction and intestinal discomfort, and treatment of intestinal cramps caused by organic diseases. ^[3]

Contraindications of mebeverine hydrochloride

1. Disable allergic to mebeverine hydrochloride.

2. Patients with intestinal obstruction are disabled.

3. Fecal impaction and colonic flaccidity (such as elderly megacolon) patients are prohibited.

4. Severe liver dysfunction is disabled. ^[3]

Precautions for mebeverine hydrochloride

1. Mebeverine hydrochloride should be taken 20 minutes before a meal, and should be swallowed whole without chewing.

2. Attention should be paid to the influence on the psychomotor ability of driving and operating robots.

3. Mild to moderate liver and kidney dysfunction should be used with caution. Use with caution in patients with cystic fibrosis and heart disease.

4. Animal experiments did not show embryo toxicity, there is no safety information on medication for pregnant women, and pregnant women should be used with caution.

5. Mebevirin hydrochloride suspension contains benzoic acid, so do not touch the eyes, skin and other mucous membranes.

6. Drug overdose can cause stress in the central nervous system. There is no specific rescue drug. Gastric lavage and symptomatic treatment are recommended. ^[2]

Adverse effects of mebeverine hydrochloride

Adverse reactions occasionally include headache, dizziness, bloating, nausea and skin allergies. Peritonitis has been reported in patients with cystic fibrosis. ^[3]

Mebeverine hydrochloride dosage

1. Adult oral tablet, 135 mg each time, 3 times a day; suspension, 150 mg each time, 3 times a day; controlled release preparation, 400 mg each time, 2 times a day.

2. Children orally over 10 years old are the same as adults; those aged 9 to 10 years old, the suspension is 100 mg each time, 3 times a day; ages 4 to 8 years old, the suspension is 50 mg each time, 3 times a day; For 3 years old, the suspension is 25mg each time, 3 times a day. ^[3]

Mebeverine hydrochloride drug interactions

This product is a pro-myogenic antispasmodic drug that directly acts on the smooth muscles of the gastrointestinal tract to relieve the symptoms of spasm without affecting normal bowel movements. This effect does not pass through the autonomic nervous system, so there is no anticholinergic effect, so this product is also suitable for patients with prostatic hypertrophy and glaucoma. ^[3]