What Is Methimazole?

Methylimidazole (4-MI for short) is an important organic intermediate. It is mainly used to synthesize the bulk stomach drug Cimetidine, and can also be used as epoxy resin curing agent and metal surface protective agent. A few years ago, China once set off a wave of production and development of this product, and made great progress in terms of technology. Facing the current international situation, experts in the industry pointed out that the task of China's 4-methylimidazole industry is still very arduous, and there is still much work to be done by related enterprises in improving product quality, reducing costs and protecting the environment.

Methylimidazole

Right!

Methylimidazole (4-MI for short) is an important organic intermediate. Mainly used to synthesize bulk stomach medicine

Since the 1980s, countries such as Germany and Japan have conducted a lot of research on 4-MI synthesis processes. At that time, the majority of foreign studies were mainly on the acetaldehyde process. In the process of pyruvaldehyde synthesis, in order to improve

use

The research on 4-methylimidazole synthesis technology in China began in the late 1980s. Tsinghua University, Tianjin University, Shanghai Institute of Petrochemical Technology and other scientific research institutions have studied their processes for a long time, but before 1994, Domestic demand for 4-methylimidazole mainly depends on imports, with prices as high as 168,000 yuan / ton.

In the 1990s, China began to research and develop the process of synthesizing 4-methylimidazole with pyruvaldehyde, and made some progress. The complete process technology for the production of 4-methylimidazole from synthetic pyruvaldehyde developed by the Shanghai Research Institute of Petroleum and Chemical Industry has successfully achieved industrial application. The yield of its finished products reached 83.6%. The purity of the reaction solution was higher than 98.5% after separation, salt exchange and vacuum distillation. The reaction conditions of the process are moderate. The unique salt exchange process and the use of water instead of methanol as a solvent are used in the post-treatment process, which better solves the environmental protection problem. Due to high synthetic yield, good product quality, ammonium oxalate recycling, low production cost and promising industrial application prospects. The 200-ton / year 4-methylimidazole production unit jointly developed by the institute and Jinling Petrochemical Company has been put into operation, and the product quality has reached the standards of similar foreign products, which can completely replace imports. At the end of 1999, the Shanghai Institute of Petrochemical Technology provided complete sets of technologies and catalysts to Jingjiang Synthetic Chemical Plant, and completed a 300-ton / year acetaldehyde and 150-ton / year 4-methylimidazole production unit.