What Is Metoclopramide Hydrochloride?

Metoclopramide hydrochloride is an antiemetic drug that can be used in chemotherapy, radiotherapy, surgery, craniocerebral injury, sequelae of traumatic brain injury, naval operations, and vomiting caused by drugs; it can also be used in acute gastroenteritis, biliary pancreas, urinary mutual disease, etc. Symptomatic treatment of nausea and vomiting of this kind of disease; Can also be used before the diagnosis of duodenal intubation to help smooth intubation; Gastrointestinal barium X-ray examination can reduce nausea and vomiting; Promote barium by.

Metoclopramide hydrochloride

Metoclopramide hydrochloride is

Metoclopramide hydrochloride

[Alias] metoclopramide,

This product is a clear, colorless liquid.

This product is a dopamine 2 (D2) receptor antagonist, and also has a 5-titan tryptamine 4 (5-HT4) receptor agonistic effect, and has a light charge inhibitory effect on 5-HT3 receptors. It can act on the dopamine receptors in the medulla oblongata chemically-sensing zone (CTZ) to increase the threshold of CTZ and has a strong central antiemetic effect. This product can also block the hypothalamic dopamine receptor, inhibit the lactopeptin inhibitory factor, and promote the secretion of prolactin, so it has a certain prolactin effect. It has less inhibitory effect on other parts of the center, has weaker stabilization effect, and less causes hypnotic effect. The effect on the gastrointestinal tract is mainly in the upper digestive tract, which promotes the movement of the stomach and upper intestine; increases the tension of the resting gastrointestinal sphincter, increases the tension of the lower esophageal sphincter and the extent of contraction, so that the lower pressure of the esophagus is increase. Blocks gastric-esophageal reflux, strengthens gastric and esophageal peristalsis, enhances the ability to clear the contents of the esophagus, promotes emptying of the stomach, promotes relaxation of the pylorus, duodenum and upper jejunum, and forms the stomach and upper body Intestinal function coordination. These effects can also enhance the antiemetic effect of this product. The transmission effect of this product on the small intestine and colon is uncertain.

After entering the blood circulation, 13% to 22% quickly bind to plasma proteins (mainly albumin). Metabolized by the liver. T2 / 1 is generally 4 to 6 hours, depending on the amount of use. The beginning time of the effect: intramuscular injection for 10-15 minutes, intravenous injection for 1 to minute, the duration is generally 1 to 2 hours, mainly excreted by the kidney as free, combined or metabolites, which can be excreted from milk.

Intramuscularly or intravenously. For adults, 10 to 20 mg (1 to 2 sticks) at a time, the daily dose does not exceed 0.5 mg / kg; for children, 0.1 mg / kg each time under 6 years old, 2.5 to 5 mg once per 6 to 14 years. For renal insufficiency, the dose is halved.

The more common adverse reactions are: lethargy, irritability, and fatigue; rare reactions are: breast swelling and pain, nausea, constipation, rash, diarrhea, sleep disturbance, dizziness, severe thirst, headache, and easy excitement; Increase in milk during medication, due to the stimulation of prolactin; injection can cause

Disabled in the following cases: those who are allergic to procaine or procainamide; the frequency and severity of seizures can be increased with medicine; gastrointestinal bleeding,

No effect on vomiting caused by motion sickness. Concentrations of aldosterone and serum prolactin can be increased by the use of metoclopramide. (3) The dose of patients with severe renal insufficiency must be reduced by at least 60%. Such patients are prone to extrapyramidal symptoms. Intravenous injection of metoclopramide must be slow. After 1 to 2 minutes of injection, rapid administration may cause restlessness, and then enter a lethargic state. Because this product can reduce

It has potential teratogenic effects and should not be used by pregnant women.

Children should not use it for a long time.

Long-term use in the elderly, prone to the symptoms of the pyramidal system.

with paracetamol powder,

Symptoms of overdose: deep drowsiness, unconsciousness; muscle spasms, such as neck and back muscle spasms, drag gait, head and facial convulsions, and extrapyramidal symptoms such as trembling and shaking hands. When overdose, the use of anticholinergic drugs, treatment of Parkinson's disease or antihistamines can help stop the extrapyramidal response.

1ml; 10mg