What Is Mosapride?

Mosapride is a drug. This drug is a selective serotonin 4 (5-HT4) receptor agonist, which can promote the release of acetylcholine, stimulate the gastrointestinal tract and exert promotive effects, thereby improving functional dyspepsia The patient's gastrointestinal symptoms did not affect gastric acid secretion.

This medicine has no affinity with dopamine D2 receptors, epinephrine 1 receptors, 5-HT1 and 5-HT2 receptors on the synaptic membrane of brain nerve cells, so it will not cause extrapyramidal syndrome and cardiovascular adverse reactions.

Chinese name: Mosapilli
Foreign name: Mosapride

Brain nerve: cell
Mosapilli: Mosapride citrate
Approval date: 2005

Mosapride drug name

Chinese common name: Mosapride

Common name in English: Mosapride

Other names: Meiweining, Belona, Gastron, Kuaili, Ruiqi, Xinluna, Gasmotin. Mosapride is a base, which is more stable when it forms salts with acids. Most of the acids used are citric acid (also useful in hydrochloric acid), so Mosapride is also called Mosapride Citrate)

Mosapride Quality Standard

Product name

Approval Number

Approval date

category

Expiration date

Packaging specifications

Mosapride citrate capsules

National Medicine Standard H20051719

Produced by Shanghai Xinyi Pharmaceutical Factory Co., Ltd.

2005

Western medicine

24 months

5mg

Quality Standard

project	Standard ( Huyuan Medicine )
Character	White or off-white crystalline powder; odorless.
Solubility	It is slightly soluble in ethanol, almost insoluble in water and chloroform, and easily soluble in glacial acetic acid.
Identify
A	HPLC
B	Differential response of citrate
C	IR
Fluorine (%)	2.6 ~ 3.2
Chloride (%)	0.01
Related substances (%)
Total impurities	1.0
Moisture ( Karfisch method ,%)	5.0 ~ 6.5
Ignition residue (%)	0.1
Heavy metal (ppm)	20
Content (%)	98.5
remaining solvent	Compliance

Clinical application of mosapride

1. For functional dyspepsia accompanied by heartburn, belching, nausea, vomiting, early satiety, upper abdominal distension, upper abdominal pain and other gastrointestinal symptoms.

2. It can also be used for gastric dysfunction in patients with gastroesophageal reflux disease, diabetic gastroparesis and partial gastric resection.

Mosapride Pharmacology

It is absorbed quickly after oral administration, and has a higher concentration in the gastrointestinal tract and local tissues of liver and kidney, followed by plasma, and there is almost no distribution in the brain. Healthy subjects took 5mg of the drug, the peak time (Tmax) of the blood concentration was 0.8 hours, the peak blood concentration (Cmax) was 30.7ng / ml, the half-life was 2 hours, and the area under the curve (AUC) was 67 (ng · H) / ml, the apparent volume of distribution (Vd) is 3.5L / kg, the plasma protein binding rate is 99%, and the total clearance rate is 80L / h. This drug is metabolized in the liver by cytochrome P4503A4, and the metabolite is mainly 4-fluorobenzyl mosapride. It is excreted mainly in the form of metabolites through urine and feces, and the original drug only accounts for 0.1% in urine.

Mosapride Precautions

1. Contraindications (1) Those who are allergic to this medicine. (2) Those with gastrointestinal bleeding and perforation. (3) Patients with intestinal obstruction.

2. Use with caution (1) Youth. (2) Hepatic and renal insufficiency. (3) People with a history of heart failure such as heart failure, conduction block, ventricular arrhythmia, and myocardial ischemia (foreign data). (4) Electrolyte disorders (especially hypokalemia) (foreign data).

3. The effect of drugs on children The safety of children's medication has not been determined (no experience in use), and children are advised to use this medication with caution.

4. The effects of drugs on the elderly The elderly should pay attention to observations when taking medications, and appropriate treatment should be given immediately when adverse reactions occur (such as reducing doses).

5. The impact of drugs on pregnancy The safety of pregnant women's medication has not been determined. It is recommended that pregnant women should avoid using this medicine.

6. The effect of drugs on lactation The safety of lactating women has not been determined, and it is recommended that lactating women should avoid using this medicine.

7. The effect of the drug on the test value or diagnosis The drug can cause eosinophilia and serum triacylglycerol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and -glutamyl transferase (-GT) and other test values increased.

8. Blood biochemical examinations should be routinely performed before, during, and after treatment, or during treatment. Patients with a history of cardiovascular disease or patients with antiarrhythmic drugs should undergo regular ECG examinations.

Mosapride adverse reactions

1. After taking this medicine, the main manifestations are diarrhea, abdominal pain, dry mouth, rash, burnout, dizziness, discomfort, palpitations, vomiting and other adverse reactions.

2. In addition, abnormal changes in the electrocardiogram may still occur.

3. Animal reproductive toxicity studies have shown that this drug has no obvious teratogenic effect and no mutagenic effect.

[Reference of adverse reactions abroad]

1. Case report of cardiovascular system, a 68-year-old male patient experienced QT interval prolongation and apical torsional ventricular tachycardia after 2 weeks of using this drug (15 mg a day), but it is not known whether it is related to this drug clear.

2. Central nervous system It has been reported that some patients experienced headaches during medication. No extrapyramidal adverse reactions have been reported.

3. Metabolic / endocrine system Some patients have increased serum cholesterol and triacylglycerol values after taking the drug, but the relationship with this drug is unclear.

4. A non-control study of the digestive system shows that the incidence of constipation and nausea can reach 10% in patients with chronic gastritis taking 1.5-15 mg of this drug a day, which shows that serum aminotransferase levels are increased and dry mouth is rare. ; Use this medicine (40mg once, 4 times a day, 2 days in a row) to treat gastroesophageal reflux disease, the most common adverse reactions are nausea, vomiting and abdominal pain.

5. Eosinophilia and lymphocytosis are occasionally seen in blood, but the relationship with this drug is unclear.

Mosapride Drug Interactions

· Drug-drug interaction

Combination with anticholinergic drugs (such as atropine sulfate, bromobutyl scopolamine, etc.) may reduce the effect of this drug.

Mosapride dosing instructions

1. After taking this medicine for a period of time (usually 2 weeks), if the functional gastrointestinal symptoms do not improve, the medicine should be discontinued.

2. When combined with anticholinergic drugs, there should be a certain interval.

3. Caution should be used in combination with drugs that can prolong the QT interval (such as procaine, quinidine, flukanib, sotalol, tricyclic antidepressants, etc.) to avoid increasing the risk of arrhythmia .

4. Caution should be exercised when combining this medicine with medicines that can cause hypokalemia to avoid increasing the risk of arrhythmia.