What Is OnabotulinumtoxinA?

Botulinum toxin (English: BTX, Botulinum Toxin), also known as botulinum toxin or botulinin, is a neurotoxin protein produced by botulinum toxin during reproduction. Botulinum toxin is a 150kD polypeptide, which is connected by a 100kD heavy (H) chain and 50kD light (L) chain through a disulfide chain. According to its toxicity and antigenicity, it is divided into 8 types: A, B, Ca, Cb, D, E, F, and G. Botox is one of the most toxic natural substances and one of the most toxic proteins in the world. 1 mg of purified and crystallized botulinum toxin can kill 200 million mice, with a human lethal dose of 40 IU / Kg. However, it is stable in nature and easy to produce, purify and refine. So it was first used in experimental research and clinical.

Botulinum toxin, referred to as botulinum toxin, is a bacterial endotoxin secreted by the deadly botulinum toxin during reproduction and has severe neurotoxicity. According to data, it is by far the most toxic biotoxin discovered by scientists, and its toxicity is equivalent to 10,000 times the equivalent amount of potassium cyanide. ^[1]

Botox is not caused by living

There are only three countries in the world that can produce botulinum botulinum for beauty: the United States, the United Kingdom, and China. The manufacturers in these three places gave it different names. In the United States, it is called Botox, in the United Kingdom it is called Dysport, and in China, It's called Btxa. There is no difference in the quality of botulinum toxin in the above three countries, but the British Dysport has not yet been approved by the China Food and Drug Administration SFDA. The smuggling of botulinum without tariffs has no quality guarantee and is dangerous to use.

Since botulinum toxin is a nerve anesthetic, it can temporarily paralyze muscles. The medical community has used it as a therapeutic drug for the first time in clinical treatment of strabismus. It has a history of 30 years and has now been developed to treat various diseases. This kind of local dystonia is stable and reliable.

At first, doctors used botulinum toxin to treat facial spasms and other muscle movement disorders, and used it to paralyze muscle nerves in order to stop muscle spasms. During the treatment, doctors found that botulinum toxin has a more significant effect in eliminating wrinkles. Soon, cosmetic surgery with injection of botulinum came into being, and it quickly swept the world.

Botulinum toxin paralyzes and relaxes the subcutaneous nerves, which can eliminate wrinkles or prevent the formation of wrinkles for a period of time, thereby achieving a cosmetic effect. Because botulinum toxin is more expensive and requires continuous injections to maintain its effect, it has always been a luxury that only Hollywood actresses and ladies have been able to spend for many years.

Botox injection surgery has certain risks. It must be performed by a professional dermatologist or facial surgeon to be safe and reliable. In general, beauty salons should not have this ability.

Since botulinum toxin is a nerve anesthetic, it can temporarily paralyze muscles. For the first time since 1979, the medical profession has used it as a therapeutic drug in clinical treatment.

Botulinum toxin is a neurotoxin secreted by Clostridium botulinum, and it is also the most toxic substance known to biological toxins and chemical toxins (potassium cyanide). kg, when a person eats food containing botulinum toxin, the incubation period is 6 hours to 12 days, usually 3 to 4 days, clinical symptoms appear, and the patient eventually died of respiratory failure. According to the different antigenicity of botulinum toxin protein, botulinum toxin is divided into 7 serotypes of AG, among which types A, B, E, and F are likely to cause human botulism, and types C and D are likely to cause botulism in animals. G Type is rare ^[2]

Botox eliminates wrinkles by paralyzing the muscles and making the muscles unable to beat, so it sometimes produces adverse reactions such as headaches, allergies, diplopia and unnatural expression. This is just for normal people. For special people, there are 5 types of people who cannot use botox to remove wrinkle and beauty: ^[4]

1. Pregnant women and lactating women

2. Patients with myasthenia gravis, multiple sclerosis

3.Ptosis of the upper eyelid

4. People who are very thin and have visceral diseases such as heart, liver and kidney

5. Those with allergies