What Is Prazosin?

Prazosin can block the sympathetic nerve's innervation of vascular smooth muscle, expand peripheral resistance vessels and volume vessels, reduce peripheral vascular resistance, and lower blood pressure. This product can still dilate the coronary arteries, reduce the pre- and post-load of the heart, reduce myocardial oxygen consumption, and improve myocardial function, but the cardiac output is slightly increased or unchanged. It sometimes even decreased without any significant effect on renal blood flow and tubular filtration rate. Effective after 0.5 to 2 hours after taking this product, the effect can be maintained for 6 to 10 hours. The antihypertensive effect is unbalanced with the plasma drug concentration.

Basic Information

Chinese name

Prazosin

Foreign name

Prazosin

Molecular formula

C19H21N5O4 · HCl

Preparation

Tablets, 0.5mg each; 1mg; 2mg 33mg

Prazosin indications

It is suitable for mild to moderate hypertension. As a second-line drug, it is often used or combined when the first-line drug treatment is not satisfactory. It is also used to treat congestive heart failure, mainly in severely refractory patients. It is also used to treat ergotamine overdose.

Clinical application of prazosin

Oral: Start 0.5 1mg / time, 3 times / day, then gradually increase to 6 15mg / day, and take in divided doses. Treatment of congestive heart failure and heart failure after myocardial infarction, the maintenance amount is usually 4-20mg / day, divided into doses.

Prazosin adverse reactions

Nausea, dizziness, headache, drowsiness, palpitations, orthostatic hypotension, known as the "first dose phenomenon", can be taken before bedtime or from 0.5mg to avoid it, occasionally dry mouth, rash, fever Polyarthritis and so on.

Prazosin precautions

Allergies are prohibited; drowsiness and orthostatic hypotension may be present when first served. May cause hypothermia in the elderly. The dose should be reduced when the renal function of the elderly is reduced. The dosage must be individualized, and blood pressure changes should be observed during the medication to reduce the blood pressure response. This medicine should be taken under the guidance of a physician. The first dose is 0.5mg. If there are no adverse reactions, the dose can be gradually increased. It should not be too fast or too much.

(Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.)