What Is Salbutamol Sulfate?

Salbutamol sulfate is suitable for bronchial asthma, wheezing bronchitis and emphysema, etc. It is usually used for aerosol inhalation, and can be administered orally for the prevention of seizures.

Salbutamol sulfate

Salbutamol sulfate, suitable for

Aerosol inhalation is usually used to relieve seizures, while oral administration can be used to prevent seizures. Oral: 2mg ~ 4mg / time for adults, 3 times / day; 0.1mg ~ 0.15mg / kg for children, 2 ~ 3 times / day. Controlled-release tablets: 8 mg / time, 2 times / day. Aerosol inhalation: 0.1 ~ 0.2mg (1 ~ 2 sprays) each time, if necessary, it can be repeated once every 4h, but it should not exceed 6 ~ 8 times within 24h.

Pregnancy class C. Use with caution in patients with cardiovascular insufficiency, hypertension, hyperthyroidism, diabetes, and pregnancy. Increased use of inhaled short-acting b2-receptor agonists to control symptoms and show a decline in control of asthma. If this occurs, the patient's treatment should be re-evaluated. Sudden and gradual decline in the control of asthma, patients' lives may be at risk and consideration should be given to starting or increasing

Method name: Salbutamol Sulfate-Determination of Salbutamol Sulfate-Non-aqueous Titration Method

Scope of application: This method uses a non-aqueous solution titration method to determine the content of salbutamol sulfate ((C13H21NO3) 2 · H2SO4).

This method is applicable to the determination of salbutamol sulfate.

Principle of the method: After the test product was dissolved in glacial acetic acid, let it cool, add 15 mL of acetic anhydride and 1 drop of crystal violet indicator solution, and titrate with perchloric acid titration solution (0.1 mol / L) until the solution was blue-green. The titration results are corrected with a blank test. Each 1mL of perchloric acid titration solution (0.1 mol / L) is equivalent to 57.67mg of (C13H21NO3) 2 · H2SO4.

Reagent: 1. Water (new boiling to room temperature)

Glacial acetic acid

Acetic anhydride

Crystal violet indicator liquid

5. Perchloric acid titrant (0.1mol / L)

6. Reference potassium phthalate

equipment:

Sample preparation: 1. Crystal violet indicator liquid

Take 0.5 g of crystal violet and add 100 mL of glacial acetic acid to dissolve.

2. Perchloric acid titrant (0.1mol / L)

Preparation: Take 750mL of anhydrous glacial acetic acid (calculated with water content, add 5.22mL of acetic anhydride per 1g of water), add 8.5mL of perchloric acid (70 ~ 72%), shake well, let cool, add an appropriate amount of anhydrous glacial acetic acid 1000mL, shake well and leave for 24 hours. If the test sample is easily acetylated, the water content of the solution must be determined by the moisture measurement method, and then the water content of the solution is adjusted to 0.01% ~ 0.2% with water and acetic anhydride.

Calibration: Take about 0.16g of standard potassium hydrogen phthalate dried to constant weight at 105 , accurately weigh, add 20mL of anhydrous glacial acetic acid to dissolve, add 1 drop of crystal violet indicator solution, and slowly titrate with this solution to Blue, and the titration results are corrected with a blank test. Each 1mL of perchloric acid titration solution (0.1mol / L) is equivalent to 20.42mg of potassium hydrogen phthalate. Calculate the concentration of this solution based on the consumption of this solution and the amount of potassium hydrogen phthalate taken.

3. Reference potassium phthalate

Storage: Place in a brown glass bottle and keep tightly closed.

Operation steps: Take about 0.4g of this product, accurately weigh, add 10mL of glacial acetic acid, dissolve at a slight temperature, let cool, add 15mL of acetic anhydride and 1 drop of crystal violet indicator solution, and use perchloric acid titrant (0.1 mol / L) Titrate until the solution turns blue-green, and correct the results of the titration with a blank test. Each 1mL of perchloric acid titration solution (0.1 mol / L) is equivalent to 57.67mg of (C13H21NO3) 2 · H2SO4.

Note 1: "Precision weighing" means that the weighed weight should be accurate to one thousandth of the weight. Precision requirements.

Note 2: "Determination of moisture" uses the drying method, taking 2 to 5 g of the test sample, and spreading it in a flat weighing bottle that is dry to constant weight, the thickness does not exceed 5 mm, and the loose test sample does not exceed 10 mm. Open the bottle cap and dry at 100 ~ 105 ° C for 5 hours. Place the cap on the dryer, cool it for 30 minutes, and weigh it precisely. Then dry it at the above temperature for 1 hour, cool, and weigh until two times in a row. The difference in weighing does not exceed 5 mg. Calculate the moisture content (%) in the test product based on the weight lost.

References: Pharmacopoeia of the People's Republic of China, compiled by the National Pharmacopoeia Committee, Chemical Industry Press, 2005 edition, Part Two, p.733.