What Is the Difference Between Amitriptyline and Nortriptyline?

Nortriptyline, a metabolite of amitriptyline, has an antidepressant effect and works quickly. It is suitable for patients with depression and anxiety. Can also be used for anxiety.

Drug Name: Nortriptyline
Foreign name: Nortriptyline

Dosage: Oral: 10mg
Tablets: 10mg; 25mg

Nortriptyline Basic Information

Chinese name:

English name: nortriptyline

English alias: allegron; Aventyl; Sesaval; notriptyline; Avantyl; desmethylamitriptyline; [14C] -Nortriptyline; NORTRIPTYLINE; Psychostyl; Ateben; noramitriptyline; lambeck; Noritren; Lumbeck;

CAS number: 72-69-5

Molecular formula: C ₁₉ H ₂₁ N

Molecular weight: 263.37700

Exact mass: 263.16700

PSA: 12.03000

LogP: 4.21730

Structural formula:

Physical and Chemical Properties of Nortriptyline

Density: 1.084 g / cm ³

Boiling point: 403.4ºC at 760 mmHg

Flash point: 194.9ºC

Refractive index: 1.633 ^[1]

Nortriptyline Safety Information

Customs Code: 2921499090

Nortriptyline Toxicology Data

Acute toxicity: Rat oral LD50: 502 mg / kg; rat intravenous LD50: 22 mg / kg;

Mice oral LD50: 370 mg / kg; mouse abdominal LD50: 70 mg / kg; mouse intravenous LD50: 17 mg / kg;

Nortriptyline molecular structure data

1. Molar refractive index: 86.76

2. Molar volume (m ^{3 /} mol): 242.8

3. Isometric Zhang Rong (90.2K): 636.9

4. Surface tension (dyne / cm): 47.3

5. Polarizability (10-24cm3): 34.39

Nortriptyline calculated chemical data

1. Hydrophobic parameter calculation reference value (XlogP): None

2. Number of hydrogen-bonded donors: 1

3. Number of hydrogen bond acceptors: 1

4. Number of rotatable chemical bonds: 3

5. Number of tautomers: none

6. Topological molecular polar surface area 12

7. Number of heavy atoms: 20

8. Surface charge: 0

9. Complexity: 307

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Uncertain number of chemical bond stereocenters: 0

15. Number of covalent bond units: 1 ^[2]

Nortriptyline Nortriptyline related drug label information

Nortriptyline Classification Name

First level classification: Nervous system drugs Second level classification: Antidepressant drugs Third level classification: Tricyclic drugs

Nortriptyline drug dosage form

Tablet: 10mg, 25mg.

Pharmacological effects of nortriptyline

This product is a diphenylcycloheptadiene tricyclic antidepressant. It is the main active metabolite of amitriptyline. The effect and application are similar to amitriptyline, and it works quickly.

Nortriptyline Pharmacokinetics

Nortriptyline indications

Nortriptyline contraindications

Severe heart disease, glaucoma and dysuria are prohibited.

Nortriptyline precautions

Safety for elderly, children, pregnant and lactating women: This medicine is not recommended for children. The effects on the fetus are unclear, so pros and cons should be weighed against the use of pregnant women.

Nortriptyline adverse reactions

Common dry mouth, lethargy, constipation, blurred vision, tachycardia, orthostatic hypotension in individual cases. Can cause liver damage, dyskinesias, and difficulty urinating.

Nortriptyline dosage

1. Treatment of depression: start oral 30mg per day, take in divided doses or once before bedtime; gradually increase to 75-100mg per day; severe depression does not exceed 150mg per day. The optimal blood concentration for its antidepressant effect is 50 to 150 mg / L. When the dose exceeds 100 mg per day, blood concentration should be monitored. The dose for adolescents and elderly patients is halved and taken in divided doses. 2. Treatment of enuresis in children: 10mg less than 7 years old, 10-20mg 8-8 years old, 25-30mg over 11 years old, taken once before bedtime, the total course of treatment does not exceed 3 months, including the time of withdrawal.

Corresponding effects of nortriptyline drugs

Nortriptyline efficacy review

This product has antidepressant effect, quick onset, and is suitable for depression patients with tension and anxiety. Can also be used for anxiety. According to foreign data, it can be used to relieve central pain, but further research is needed ^[3] .