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Condyloma acuminatum is a proliferative epithelial lesion caused by human papillomavirus infection and is one of the important sexually transmitted diseases. . The average incubation period of female genital warts is 2 to 3 months. The development of the lesions is not self-limiting. The symptoms are local itching and pain. A few patients have no symptoms. Growth site: vulva, vagina, cervix, perianal, two common parts occur at the same time, the local manifestation is light red or gray papule, wart-like protrusions, often merge to form cauliflower-like vegetation, have a history of sexual disorder, use 5% After the application of acetic acid, the lesions turned white. The incubation period of pseudocondyloma is 3 days to 3 weeks. It is self-limiting, generally asymptomatic, and some local itching is more common. The symmetry distribution of the labia minora is more common. Rarely occurs in two parts at the same time. Some were polyp-like, villi-like, non-fused, and had no history of sexual disorder. They did not become white after 5% acetic acid was applied. The cause is unknown, and some people believe that polyhormones, fungal infections, or other chronic irritation.

Condyloma acuminatum

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Condyloma acuminatum is caused by humans

Diagnosis requires strict mastery of standards.

1. Typical skin lesions are pimples on wet parts such as the genitals or perianum, nipple-shaped, cauliflower-like, or chicken crown-shaped fleshy neoplasms, and the surface is rough and keratinized.

2. The acetic acid white test is positive, and a similar erosion pattern can be seen in vivo. The middle is bright red to brown, and the color around it gradually fades.

3. Nucleic acid hybridization can detect HPV DNA related sequences, and PCR detection shows specific HPV DNA amplification bands.

4. Patients often have a history of unclean sex life or a spouse's infection. A few genital warts are infected through contact with contaminated equipment, and newborns can also be infected through the birth canal. The incubation period ranges from 1 to 8 months, with an average of 3 months.

5. Condyloma acuminata HPV virus is not soluble in the blood, but the information of the virus can be obtained by detecting serum antibodies in the blood. The advanced virus detection system can quickly test the sera to detect three items, namely "virus antibodies, virus types, and virus quantity".

Female patients suffer from genital warts of the labia very much. When the genital warts of women's labia occur in the vulva, the most typical symptom manifestation is very little reddish color, very soft and small pimples at the beginning of the onset. The development will further increase and increase, and the pimples will blend or overlap, and the surface looks very uneven, like a wart. Because some areas are very hot and humid and have chronic irritation, the warts will grow quickly and eventually become different in size, such as nipple-like, cauliflower-like, cockscomb-like or mushroom-like. These warts are very nature It is soft and bleeds very easily at the touch.

During the onset of some labia acuminatum patients, the secretions produced are white, dirty, or red, and infiltrate the surface of the wart, causing great inconvenience to the life of female patients. The root of the wart is very narrow, and it has a pedicle and a moist surface. There are often exudation, erosion, and skin damage. At the same time, there are very purulent secretions in the fissures pushing inside. Very prone to bacterial infections and a very strong stench. Symptoms felt by women themselves are very itching, burning or oppression.

Condyloma acuminatum acetic acid white test

Use 3 to 5% acetic acid to coat the wart body for 2 to 5 minutes. The lesion area will become white and slightly bulged, and anal lesions may take 15 minutes. The principle of this test is that keratin produced by HPV-infected cells is different from normal uninfected epithelial cells as a result of protein and acid coagulation and whitening. Only the former can be decolorized by acetic acid. The acetic acid white test is very sensitive in detecting HPV. It is better than conventional tests to observe histological changes. However, occasionally false positives appear in cases of thickened epithelium or traumatic abrasion. The signs of false positive whitening appear to be unclear and irregular. The US CDC suggests that the acetic acid white test is not a specific test, and false positives are more common.

Condyloma acuminatum

The peroxidase-resistant peroxidase method (ie, PAP) is commonly used to display viral proteins in genital warts to demonstrate the presence of viral antigens in wart lesions. When HPV protein is positive, the superficial epithelial cells of condyloma acuminatum may show a weak reddish positive reaction.

Histochemical examination of condyloma acuminatum

A small amount of diseased tissue was made into smears and stained with antibodies specific to human papilloma virus. If there is a viral antigen in the lesion, the antigen-antibody is bound to the peroxidase-antiperoxidase (PAP) method, and the nucleus can be stained red. This method is specific and quick to help diagnosis.