What Is Cloxacillin?

Dicloxacillin is a -lactam antibiotic. Dicloxacillin is resistant to acids and enzymes, and has antibacterial activity against staphylococci and gram-positive bacteria. Studies have shown that amoxicillin-diclocillin has a good antibacterial effect on common pathogenic bacteria and a good antibacterial effect on Salmonella typhimurium, and it can be used as one of the first choice drugs for the treatment of respiratory infections, simple skin and soft tissue infections and typhoid fever.

Dicloxacillin

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Dicloxacillin is a -lactam antibiotic. Dicloxacillin is resistant to acids and enzymes, and has antibacterial activity against staphylococci and gram-positive bacteria. Studies have shown that amoxicillin-diclocillin has a good antibacterial effect on common pathogenic bacteria and a good antibacterial effect on Salmonella typhimurium, and it can be used as one of the first choice drugs for the treatment of respiratory infections, simple skin and soft tissue infections and typhoid fever.

Chinese name

Dicloxacillin

English name

Dicloxacillin

nickname

Diclocyanine, Diclocillin, Diclofenac, Penicillin.

Chemical formula

C19H17Cl2N3O5S

Molecular weight

470.33

CAS Registry Number

3116-76-5

EINECS registration number

221-488-3

Dicloxacillin

Ingredients: This product is a compound preparation, and its components are 0.25 g of amoxicillin and 0.125 g of dicloxacillin.

Properties: This product is a film-coated tablet. It appears white or off-white after removing the coating.

1. This product is a penicillin drug, which may be severe or even fatal when treated with this product

Dicloxacillin is a broad-spectrum penicillin antibiotic, and dicloxacillin is isoxazole penicillin, which is not easily destroyed by penicillinase. This product in vitro against the following

Diclosillin

1, probenecid, aspirin,

Oral can cause gastrointestinal reactions: nausea, vomiting, loss of appetite, bloating, diarrhea, penicillin allergy are contraindicated. Individual cases can cause leukopenia, rash, fever, headache, palpitations, and neurological reactions such as large doses. Confusion, convulsions, and convulsions.

1. The most common allergic reaction to rash; oral administration can cause gastrointestinal reactions such as mild nausea, vomiting, diarrhea; renal toxicity can occur when used in large doses (200mg / kg daily).

2, more common allergic reactions: maculopapular rash (especially prone to infectious mononucleosis, cytomegalovirus infection,

HPLC determination of amoxicillin and diclocillin sodium capsules Objective: To establish a method for the determination of amoxicillin and diclocillin sodium capsules in amoxicillin and diclocillin sodium capsules.

Method: ShimadzuVP ODS column was used. The mobile phase was 0.008mol / L sodium lauryl sulfate (adjusted to pH 4.5 with phosphoric acid).

Chinese aliases diclocillin, diclofenacazole penicillin, diclofenac penicillin, diclofenac

English aliases Dicloxacillinum, Dicloxin, Maclicine, Stafopenin, Veracillin

Drug category penicillin antibiotics

Drug effect

This product has fast absorption and high blood concentration. It can reach high concentration blood drug peak within 30 minutes to 1 hour after intramuscular injection, and has no cross-resistance with other antibiotics. Low toxicity, 94% binding to serum proteins.

Indication

It is mainly used for the treatment of Staphylococcus aureus infection that is resistant to penicillin G or other antibiotics. This product is suitable for the treatment of gastrointestinal infections, urinary tract infections, respiratory infections, soft tissue infections, meningitis, sepsis, endocarditis, etc. caused by sensitive bacteria.

Dosage Oral: 0.25-0.5g / time, 4 times / day, before meals. Pediatric 25-50mg / kg daily 4 times. Intramuscular injection: 0.25-0.5g / time, once every 4-6 hours.

Important points are often allergic reactions, such as rash, urticaria, prurigo; occasional nausea, vomiting, loss of appetite, bloating, diarrhea, elevated transaminase and so on. Use with caution in newborns and those with poor liver function. Before use, penicillin potassium (sodium) is required for allergy tests.

Drug Specifications Tablet: 0.25g; powder injection: 0.5g

Function and use

This product is semi-synthetic penicillin, and its antibacterial spectrum is similar to that of clotrimazole. Its blood concentration and serum protein binding rate are high. It is mainly used for penicillin-resistant staphylococcal infections, including sepsis, endocarditis, osteomyelitis, respiratory infections, and wound infections.