What Is Thiabendazole?

Thiabendazole is a benzimidazole fungicide, its mechanism of action is to inhibit the formation of tubulin during fungal mitosis. Synthesis of Thiabendazole The mixture of 4-ethoxyformylthiazole, o-phenylenediamine, and polyphosphoric acid was stirred and heated to 125 ° C, and then heated at 175 ° C for 2h. The mixture was poured into ice water and neutralized with sodium hydroxide solution to At pH 6, crystals were precipitated, filtered, extracted with hot acetone, the extract was decolorized with activated carbon, concentrated, and dried under vacuum to prepare thiabendazole. The reaction of 4-thiazolecarboxamide (or acyl bromide) and o-phenylenediamine in condensed phosphoric acid at 240 ° C for 3h, the reactants were poured into ice water, and the filtrate was washed with 30% sodium hydroxide solution to Ph = 6, benzimidazole crystals precipitated, filtered, washed with water, dried to obtain a crude product, and then recrystallized from ethanol to obtain a finished product. ^[1]

Thiabendazole is commonly known as Tectol, Albimir, Thienazole, Thibenzimidazole, and Thibenazole. It has a systemic absorption to the top, but not to the base. Long duration, cross-resistance with benzimidazole fungicides. It has inhibitory activity on ascomycetes, basidiomycetes and semi-know fungi, and is used to prevent and cure a variety of crop fungal diseases and preserve and preserve fruits and vegetables. It is a high-efficiency, broad-spectrum, internationally-used fungicide. It is used to process 42% thiabendazole suspending agent, 60% thiabendazole wettable powder, 3% thiabendazole smoke agent, fruit cling paper, etc. Prevent and control various diseases caused by fungi on agricultural and commercial crops. Industrial antifungal agent, can be used for antifungal feed, antifungal coating, as antifungal and antiseptic for textiles, paper, leather, wire and cable and daily commercial products. Insect repellent for human and livestock intestines.
Application and dosage of Thicarbin with 15-30 grams of active ingredient sprayed on water can prevent rice blight, rice blast, citrus flower rot, cucumber, strawberry powdery mildew, strawberry, grape gray mold, celery leaf withered Sclerotinia sclerotiorum; after picking the citrus, soak the fruit with an effective concentration of 1000-1500 mg / kg for 30 seconds, remove it and dry it to prevent green and green mold during storage; after harvesting, use The effective concentration is 750 1000mg / kg after soaking the fruit for 1 3 minutes, then it is dried and stored to prevent crown rot during storage. 3% smoke agent is a patented medicine for various fungal diseases of protected vegetables. At the beginning of the disease, 300 to 400 grams of smoke agent per mu was evenly placed on the ground. The matches were lit overnight, and the doors and windows were opened for ventilation the next morning.

It is a low-toxic fungicide. The acute oral LD50 of the original drug rat is 6100 mg / kg, which has a slight irritation effect on rabbit eyes and no irritation effect on the skin. There was no carcinogenic, teratogenic and mutagenic effects at the test dose, and it had a certain toxic effect on fish.

The citrus storage disease is immersed in fruit for 4 to 5 minutes with 1000-5000 mg / kg of 45% suspension, and kept fresh for 2-3 months at low temperature.

Banana preserved with 45% suspension 500-700 mg / kg soaked in fruit for 3 minutes, removed and dried, stored at low temperature, the shelf life is more than 1 month.

1.

Toxic to fish, do not pollute ponds and water sources. The original medicine is kept tightly closed, away from children, and empty bottles should be handled properly.