What Is Tinidazole?
This product is 2-methyl-1- [2- (ethylsulfonyl) ethyl] -5-nitro-1H imidazole. Tinidazole can quickly eliminate inflammation caused by oral anaerobic bacteria, reduce symptoms, and has a better effect than the control drug.
- Drug Name
- Tinidazole
- Foreign name
- Tinidazole
- Main indications
- Septicaemia caused by anaerobic bacteria, respiratory infections, etc.
- Dosage
- Medication based on condition
- Adverse reactions
- Have gastrointestinal symptoms, individual dizziness, metallic taste in the mouth, etc.
- Main medication contraindications
- Disabled in early pregnancy and lactating women
- Pinyin name
- Tixiaozuo
- English name
- Tinidazole
- Molecular formula
- C8H13N3O4S
- This product is 2-methyl-1- [2- (ethylsulfonyl) ethyl] -5-nitro-1H imidazole. Tinidazole can quickly eliminate inflammation caused by oral anaerobic bacteria, reduce symptoms, and has a better effect than the control drug.
Tinidazole compounds
- Chinese name: tinidazole
- Chinese alias: Sulfamethanazole; Livzon Quick Service Net; Lejing; Shuanghe Yunda; for you; Methanesulfuronazole; Metronidazole; Metronidsulfonyl imidazole; Metronid ethylsulfonimidazole; Sulfonate Sulfamidazole
- English name: 1- (2-ethylsulfonylethyl) -2-methyl-5-nitroimidazole
- English alias: Simplotan; 1- (2- (Ethylsulfonyl) ethyl) -2-methyl-5-nitro-1H-imidazole; Fasigyn; Tinidazole; Tinidazolum; Fasigyn; Finidazol; Simplotan
- CAS number: 19387-91-8
- Molecular formula: C 8 H 13 N 3 O 4 S
- Molecular weight: 247.27200
- Exact mass: 247.06300
- PSA: 106.16000
- LogP: 2.13840
- Physical and chemical properties
- Appearance and properties: almost white or light yellow, crystalline powder
- Density: 1.43 g / cm 3
- Melting point: 117-121 ° C (lit.)
- Boiling point: 528.4ºC at 760 mmHg
- Flash point: 3 ° F
- Refractive index: 1.599
- Stability: stable. Incompatible with strong oxidants.
- Storage conditions: Keep sealed.
- Vapor pressure: 1E-10mmHg at 25 ° C
- Security Information
- Customs Code: 2933290090
- WGK Germany: 3
- Danger category code: R20 / 21/22; R40
- Safety instructions: S26-S36
- RTECS number: NI6255000
- Dangerous goods mark: Xn [1]
- use
- Anti-trichomonal drugs, mostly used in gynecology. It is widely used in the prevention and treatment of anaerobic infections and protozoal diseases, and is superior to metronidazole [1] .
Tinidazole Pharmacopoeia Standard
Tinidazole source (name), content (potency)
- This product is 2-methyl-1- [2- (ethylsulfonyl) ethyl] -5-nitro-1H imidazole. Calculated on dry basis, containing C8H13N3O4S shall not be less than 98.5% (for oral use) or 99.0% (for injection).
Tinidazole traits
- This product is white to light yellow crystal or crystalline powder; slightly bitter.
- This product is soluble in acetone or chloroform, slightly soluble in water or ethanol.
- Melting point
- The melting point of this product (Appendix VIC in Part Two of the 2010 Pharmacopoeia) is 125 to 129 ° C.
- Absorption coefficient
- Take this product, accurately weigh it, dissolve it with water and dilute it quantitatively to make a solution containing about 12 g per 1 ml. According to the UV-visible spectrophotometry (Appendix IVA of Pharmacopoeia Part II of the 2010 edition), measure the absorbance at 317nm and absorb. The coefficient () is 352 ~ 378.
Tinidazole identification
- (1) Take about 0.1g of this product, put it in a test tube, heat it on a small fire and melt it, that is, irritating sulfur dioxide gas will occur, and the filter paper that can wet the mercury nitrate test solution will turn black.
- (2) Take about 0.1g of this product, add 5ml of sulfuric acid solution (3 100) to dissolve, and add 2ml of trinitrophenol test solution, which will produce yellow precipitate.
- (3) The infrared light absorption spectrum of this product should be consistent with the control spectrum ("Infrared Spectra of Drugs" 665).
Tinidazole test
- Color of solution
- Take about 0.50g of this product, add 10ml of hydrochloric acid solution (4.5 100), and shake to dissolve. If it develops color, compare with the yellow-green standard colorimetric solution No. 4 (Appendix A of the second edition of the Pharmacopoeia of 2010, the first method). Deeper.
- relative substance
- Take an appropriate amount of this product, add the mobile phase to dissolve and dilute it to make a solution containing about 1mg per 1ml as the test solution; take 1ml precisely, place it in a 100ml volumetric flask, dilute to the mark with the mobile phase, and shake as Control solution. Tested according to high performance liquid chromatography (Appendix VD of Part Two of the 2010 Pharmacopoeia), using octadecylsilane bonded silica as a filler; 0.05 mol / L potassium dihydrogen phosphate solution (pH adjusted to 3.5 with phosphoric acid)- Methanol (80:20) was the mobile phase; the detection wavelength was 310 nm. The number of theoretical plates calculated from the tinidazole peak is not less than 2000, and the resolution of the tinidazole peak and the adjacent impurity peaks should meet the requirements. Take 20l of the control solution and inject it into the liquid chromatograph, adjust the detection sensitivity so that the peak height of the main component chromatographic peak is about 10% of the full range; precisely measure 20l each of the test solution and the control solution and inject them into the liquid chromatograph Record the retention time of the chromatogram to the main component peak twice. If there is an impurity peak in the chromatogram of the test solution, a single impurity must not exceed 0.5 times (0.5%) the main peak area of the control solution, and the sum of the peak areas of each impurity must not be greater than the main peak area (1.0%) of the control solution.
- Loss on drying
- Take this product and place it in a phosphorus pentoxide dryer and dry it at 60 ° C under reduced pressure to constant weight. The weight loss shall not exceed 0.5% (Appendix L of the second edition of the Pharmacopoeia of 2010 Edition).
- Residue on ignition
- Take 1.0g of this product and check it according to law (Appendix N of Part Two of the 2010 Pharmacopoeia). The residual residue shall not exceed 0.1%.
- Heavy metal
- Take the residue left under the burning residue and check it according to law (Appendix H of the 2010 edition of the Pharmacopoeia, the second method), the heavy metal must not exceed 20 parts per million (for oral use) or 10 parts per million (for injection use).
Tinidazole determination
- Take about 0.2g of this product, accurately weigh, add 10ml of acetic anhydride, dissolve slightly, let cool, add 1 drop of malachite green indicator solution, titrate with perchloric acid titration solution (0.1mol / L) until the solution is yellow-green And correct the titration results with a blank test. Each 1ml of perchloric acid titration solution (0.1mol / L) is equivalent to 24.73mg of C8H13N3O4S.
Tinidazole Category
- Anti-anaerobic bacteria, anti-trichomonas drugs.
Tinidazole storage
- Shaded and sealed.
Tinidazole preparations
- (1) Tinidazole tablets (2) Tinidazole vaginal effervescent tablets (3) Tinidazole suppositories (4) Tinidazole capsules (5) Tinidazole glucose injection (6) Tinidazole sodium chloride injection liquid
Tinidazole Drug Analysis
- Method name:
- Determination of tinidazole-neutralization titration
- Application:
- This method uses titration to determine the content of tinidazole. This method is applicable to tinidazole.
- Method principle:
- After the test product is dissolved by adding acetic anhydride slightly, add malachite green indicator solution, titrate with perchloric acid titrant (0.1mol / L) until the solution is yellow-green, record the amount of perchloric acid titrant, calculate, that is, Got.
- Reagent:
- 1. Water (newly boiled to room temperature)
- 2. Perchloric acid titrant (0.1mol / L)
- 3. Malachite green indicator fluid
- 4. Reference potassium hydrogen phthalate
- 5. Acetic anhydride
- equipment:
- Sample preparation:
- 1. Perchloric acid titrant (0.1mol / L)
- Preparation: Take 750mL of anhydrous glacial acetic acid (calculated with water content, add 5.22mL acetic anhydride per 1g of water), add 8.5mL perchloric acid (70% -72%), shake well, and slowly add acetic anhydride dropwise at room temperature. 23mL, shake while adding, shake evenly after adding, let cool, add an appropriate amount of anhydrous glacial acetic acid to 1000mL, shake well, and leave for 24 hours. If the test sample is easily acetylated, the water content on this page must be determined by moisture measurement, and then the water content of this solution should be adjusted to 0.01% -0.2% with water and acetic anhydride.
- Calibration: Take about 0.16g of standard potassium hydrogen phthalate dried to constant weight at 105 , accurately weigh, add 20mL of anhydrous glacial acetic acid to dissolve, add 1 drop of crystal violet indicator solution, and titrate slowly with Blue, and the results of the titration are corrected with a blank test. Each 1mL of perchloric acid titration solution (0.1mol / L) is equivalent to 20.42mg of potassium hydrogen phthalate. Calculate the concentration of this solution based on the consumption of this solution and the amount of potassium hydrogen phthalate taken.
- Storage: Place in a brown glass bottle and keep tightly closed.
- 2. Malachite green indicator fluid
- Take 0.3g of malachite green and add 100mL of glacial acetic acid to dissolve.
- Steps:
- Accurately weigh 0.2g of this product, add 10mL of acetic anhydride to dissolve, add 1 drop of malachite green indicator solution, titrate the solution yellow-green with perchloric acid titrant (0.1mol / L), and correct the titration result with a blank test. Record the volume of perchloric acid titrant consumed (mL). Each 1mL of perchloric acid titrant (0.1mol / L) is equivalent to 24.73mg of tinidazole (C8H13N3O4S), that is, obtained.
- Note 1: "Precise weighing" means that the weighed weight should be accurate to one thousandth of the weighed weight. "Precision weighing" means that the accuracy of the measured volume should conform to the national standard for the volume of the pipette. Precision requirements [2] .
Tinidazole Drug Description
Tinidazole pharmacological effects
- Tinidazole and metronidazole are both nitroimidazoles. It has good activity on protozoa (lysolytic amoeba, trichomoniasis, etc.) and anaerobic bacteria. It has better effects on amoeba and Giardia lamblia than metronidazole. Gram-positive anaerobic bacteria (Pseudococcus, Digestive Streptococcus, Lactobacillus), Clostridium and Clostridium difficile are all sensitive to this product; this product is sensitive to B. fragile, Fusobacterium Gram-negative anaerobic bacteria such as Cocci are slightly better than metronidazole, and Campylobacter jejuni is moderately sensitive to this product. Actinomyces and Propionibacterium are resistant to this product. Its mechanism of action is to inhibit the synthesis of pathogenic DNA and to quickly enter cells [3] .
Tinidazole pharmacokinetics
- The oral absorption is complete. After taking a single dose of 150mg, the peak plasma concentration is 4.91mg / L in 3 hours, and the oral blood concentration is 2g.
- Tinidazole
Tinidazole indications
- This product is often used in combination with other anti-aerobic drugs to treat various anaerobic bacteria [4] caused by sepsis, respiratory infections, abdominal and pelvic infections, unclean abortion, cellulitis, etc. to obtain satisfactory results. This product can also be used in combination with aminoglycosides and other antibiotics to prevent postoperative infections in surgical colon, rectal surgery, oral surgery, and obstetrics and gynecology. Tinidazole has a cure rate of more than 90% for trichomoniasis, Giardia lamblia, and amoebiasis. For the treatment of urogenital trichomoniasis in men and women; infections caused by sensitive anaerobic bacteria (such as Bacteroides fragile, Bacteroides, Clostridium, Clostridium, etc.), such as pneumonia, pulmonary abscess and other respiratory tracts Gynecological infections such as infections, intraperitoneal infections, endometritis, fallopian tube abscesses, oral infections such as periodontitis, pericoronitis, etc. Systemic and local infections for anaerobic bacteria, such as infections of the abdominal cavity, gynecology, surgical wounds, skin and soft tissues, lungs, chest, etc. as well as sepsis, intestinal or urogenital trichomoniasis, piriformis, and intestines And liver amoebiasis [3] .
Tinidazole dosage
- Anaerobic system infection: oral 2g daily, in severe cases can be intravenously infused, 1.6g daily, once or divided into two administrations. Prevention of surgical infection: take 2g 12 hours before the operation, and infuse 1.6g (or 2g orally) infusion during or after the operation. Non-specific vaginitis: 2g daily for 2 days. Acute odontitis: 2 g orally once. Urogenital trichomoniasis: 2 g orally once, repeated once if necessary. Or 0.15g each time, 3 times a day for 5 days. Men and women must be treated together to prevent reinfection. Children once 50 75mg / kg, repeat once if necessary. Patients with combined Candida albicans infection must undergo antifungal therapy at the same time. Piriformis flagellosis: 2g at a time. Intestinal amoebiasis: 2 g daily for 2 to 3 days. Children 50 60mg daily for 5 days. Liver amoebiasis: 1.5 to 2 g daily for 3 consecutive days, and can be extended to 5 to 10 days if necessary. The pus should be drained at the same time. Oral tablets should be taken between meals or after meals. The intravenous drip should be no less than 20 minutes per 400 mg (200 ml). Sometimes there are various neurological disorders, such as dizziness, dizziness, and ataxia, and medication should be discontinued when abnormal neurological symptoms occur. The drip rate of this product should be slow, for those with a concentration of 2mg / ml, about 40 to 90 minutes per bottle, and for those with a concentration of more than 2mg / ml, the drip rate should be extended 1 to 2 times.
- 1. Trichomoniasis: 2g serving, repeated once every 3 to 5 days.
- 2. Intestinal amoebiasis: 500 mg each time, 2 times a day for 5 to 10 days; or 2 g serving, once a day, for 2 to 6 days.
- 3 Parenteral amoebiasis: 2g, once a day, once a day for 3 to 5 days.
- 4 Giardiasis: 2g serving.
- 5. Anaerobic infection: 2g first dose, 1g daily thereafter; or 0.5g each time, 2 times daily for 5 to 6 days.
- 6. Prevention of anaerobic infections after surgery: take 2g once a day before surgery.
- 7. This product has little effect on amoeba cysts, and should be added with cysticidal drugs.
Tinidazole adverse reactions
- Adverse reactions are few and mild, occasional gastrointestinal symptoms, individual dizziness, irritation of oral metal, rash, head
- Tinidazole
- 1. Metallic taste in the mouth, digestive tract discomfort (such as nausea, vomiting, stomach pain, etc.).
- 2. Allergic reactions, such as rash, hives, itching.
- 3 Headache, tiredness, dizziness, dark urine, etc. A small number of patients can see gastrointestinal reactions, such as nausea, vomiting, decreased appetite, and oral sweetness. Individual patients can see symptoms of neurological disorders, such as dizziness, headache, dizziness, and ataxia, and occasional transient seizures. Occasionally, slight phlebitis at the infusion site. Rare allergic reactions, such as rash, pruritus, urticaria, angioedema, and transient leukopenia [3] .
Tinidazole contraindications
- Although this product is not teratogenic, it can be excreted through the placenta or through breast milk, so it is best not to use it in early pregnancy and lactating women. Those who are allergic to this product are prohibited. Avoid alcohol and alcohol-containing beverages during the medication. Otherwise, a sulfur-like reaction to quit alcohol may occur, which may cause abdominal cramps, facial flushing or vomiting. Those who are allergic to tinidazole and nitro-nitrosonitroimidazole derivatives are contraindicated. Hematological patients or those with a history of blood disease are prohibited. Disabled in patients with organic neurological diseases. Disabled or unsuitable for patients under 12 years of age.
Tinidazole drug interactions
- This product has the effect of inhibiting acetaldehyde dehydrogenase and strengthening the effect of alcohol. Disulfiram-like reactions can occur after drinking medicine or taking alcohol-containing beverages, which can cause abdominal cramps, burning sensation and vomiting. Avoid drinking alcohol. When this product is used together with anticoagulants, it can enhance the efficacy of anticoagulants. Pay attention to the prothrombin time and adjust the dosage.
Tinidazole Hazard
- 1. Tinidazole can cause carcinogenic and mutagenic effects. Animal tests or in vitro tests have found that the product has carcinogenic and mutagenic effects, but there is no data in humans [5] .
- 2. Tinidazole can interfere with the test results of alanine aminotransferase, lactate dehydrogenase, triglycerides, hexokinase, etc., making its measured value fall to zero.
- 3. Alcoholic beverages should not be consumed during medication, as it can cause acetaldehyde accumulation in the body and interfere with the oxidation process of alcohol, leading to disulfiram-like reactions. Patients may experience abdominal cramps, nausea, vomiting, headache, facial flushing, etc.
- 4. If this product is used in patients with Candida infection, the symptoms will be aggravated and antifungal treatment should be given at the same time.
- 5. In patients with liver dysfunction, the metabolism of the product is slowed down, and the drug and its metabolites are easy to accumulate in the body. It should be reduced and monitored for blood drug concentration.
- 6, can be continuously cleared from gastric juice, some placed in the stomach tube to attract decompression, can cause blood concentration to drop.
Tinidazole preparations
- 1. Treatment of genitourinary trichomoniasis:
- a. Single therapy: Adults and children over 12 years old take 2g single serving, their spouses should take at the same time; children over 6 years old take 1g single serving; single cases need to be repeated once, or as directed by a doctor.
- b. Multiple therapies: Adults take once a day, 1g each time, double for the first time, even for 3 days, or as directed by a doctor.
- 2. Treatment of anaerobic infections: Adults and children over 12 years old take 2g orally on the first day, and then take 1g every 24 hours. The medication is usually 5-6 days, depending on the condition, or as prescribed by your doctor.
- 3 Treatment of oral infections: Adults take 1g once a day, double for the first time, even for 3 days, or as directed by a doctor. 100ml: Tinidazole 0.4g + glucose 5g. Tablets: 0.5g each. Injection: 400mg / 200ml or 800mg / 400ml (containing 5.5% glucose) per bottle. Glass bottle.
Tinidazole capsule preparation
- English name: TinidazoleCapsules
- Category: Western medicine
- Pharmacological action
- This product has high activity on protozoa and anaerobic bacteria. It has antibacterial activity against Bacteroides, Clostridium, Clostridium, Pseudococcus, Digestive Streptococcus, Weissococcus, and Gardnerella, etc., at a concentration of 2 to 4mg / L, which can inhibit most anaerobe Microaerobic bacteria, Helicobacter pylori are sensitive to it; MIC to Trichomonas vaginalis is similar to metronidazole, and its metabolites are stronger than tinidazole. The mechanism of action of this product has not been fully elucidated. Nitroreductase of anaerobic bacteria plays an important role in energy metabolism of sensitive strains. The nitro group of this product is reduced to a kind of cytotoxicity, which acts on the DNA metabolism process of bacteria and promotes the death of bacteria. Drug-resistant bacteria often lack nitroreductase and are resistant to this product. The anti-amoeba protozoa mechanism of this product is to inhibit its redox reaction, to break the nitrogen chain of the protozoa, thereby killing the protozoa. This product is a capsule.
- dynamics
- The product is completely absorbed after oral administration, and the peak time (Tmax) of healthy women after a single oral dose of 2g is 2 hours, and the peak plasma concentration (Cmax) is 51mg / L. Tinidazole was excreted slowly, with plasma concentrations of 19.0 mg / L, 4.2 mg / L, and 1.3 mg / L at 24 hours, 48 hours, and 72 hours after oral administration of 2 g. Oral administration of 1g daily, blood concentration can be maintained above 8mg / L. Tinidazole is widely distributed in the body. It can reach higher concentrations in the reproductive organs, intestines, abdominal muscles, and breast milk. It has low concentrations in the liver and fat. The concentrations in bile and saliva are similar to those in the same period. The penetrability to the blood-cerebrospinal fluid barrier is higher than that of metronidazole. The concentration of cerebrospinal fluid in the meninges without inflammation is 80% of the blood concentration in the same period, which is related to the higher fat solubility of tinidazole. Tinidazole can pass through the blood placental barrier and can reach high concentrations in the fetus and placenta. The protein binding rate was 12%. In liver metabolism, about 16% is excreted from the urine in the original form after a single dose of 0.25g. The blood elimination half-life (t1 / 2) was 11.6 to 13.3 hours, with an average of 12.6 hours.
- Indication
- 1. It is used for various anaerobic infections, such as sepsis, osteomyelitis, abdominal infection, pelvic infection, pulmonary bronchial infection, sinusitis, skin cellulitis, periodontal infection and postoperative wound infection.
- 2. It is used for preoperative prevention of colorectal surgery, gynecological and obstetric surgery and oral surgery.
- 3 For intestinal and extra-intestinal amoebiasis, trichomoniasis, giardiasis, Gardnerella vaginitis, etc.
- 4 It can also be used as a substitute for metronidazole for the treatment of gastrosinusitis and peptic ulcer caused by Helicobacter pylori.
- Dosage
- oral. 1. Anaerobic infection: 1g at a time, once a day, the first dose is doubled, the general course of treatment is 5-6 days, or according to the condition.
- 2. Prevention of anaerobic infection after surgery: take 2g once a day 12 hours before surgery.
- 3 Protozoal infection:
- (1) Vaginal trichomoniasis and giardiasis: A single dose of 2 g of administered to children, 50 mg / kg of administered to children, repeated once every 3 to 5 days.
- (2) Intestinal amoebiasis: 0.5g once, twice a day, for a course of 5 to 10 days; or 2g, once a day, for a course of 2 to 3 days; children at 50mg / kg a day, take the meal , 3 days of treatment.
- (3) Parenteral amoebiasis: 2g at a time, once a day for 3 to 5 days.
- Adverse reactions
- Adverse reactions are rare and mild. They are mainly nausea, vomiting, epigastric pain, decreased appetite and oral metal smell, headache, dizziness, pruritus, rash, constipation, and general malaise. In addition, there may be neutropenia, disulfiram-like reactions, and black urine. High doses can also cause seizures and peripheral neuropathy.
- Taboo
- Patients who are allergic to this product or pyrrole drugs and those with active central nervous disease and hematological disease are prohibited.
- Precautions
- 1. Carcinogenic and mutagenic effects: Animal tests or in vitro tests have found that this product has carcinogenic and mutagenic effects. There is no data in humans.
- 2. If adverse reactions of the central nervous system occur during the course of treatment, the drug should be stopped in time.
- 3 This product can interfere with the test results of alanine aminotransferase, lactate dehydrogenase, triglyceride, hexokinase, etc., making its measured value fall to zero.
- 4 Alcoholic beverages should not be consumed during medication, as they can cause acetaldehyde accumulation in the body and interfere with the oxidation process of alcohol, leading to disulfiram-like reactions, and patients with abdominal cramps, nausea, vomiting, headache, facial flushing, etc.
- 5. In patients with liver dysfunction, the metabolism of the product is slowed down, and the drug and its metabolites are easy to accumulate in the body. It should be reduced and monitored for blood drug concentration.
- 6. The product can be continuously cleared from gastric juice, and some gastric tubes can be used to attract decompression, which can cause blood concentration to decrease. During hemodialysis, the product and its metabolites are quickly removed, so there is no need to reduce the amount of this product.
- 7. Candida infection patients who use this product will worsen their symptoms and need to be given antifungal treatment at the same time.
- 8. This product has little effect on amoeba cysts, and should be added with cysticidal drugs.
- 9. When treating vaginal trichomoniasis, their sexual partners need to be treated at the same time. still uncertain. The product can enter the fetal circulation quickly through the placenta. Animal experiments have found that intraperitoneal administration is toxic to fetuses, while oral administration is non-toxic. The effect of this product on the fetus has not been adequately and closely controlled, so it should be disabled within 3 months of pregnancy. Pregnant women over 3 months should only use this product if they have clear indications. The concentration of this product in milk is similar to that in blood. Animal tests have shown that this product has a carcinogenic effect on young rats, so lactating women should avoid using it. If medication is necessary, breastfeeding should be suspended and breastfeeding should not be allowed until 3 days after the medication is stopped. Due to liver failure in the elderly, the pharmacokinetics of this product have changed, and blood concentrations need to be monitored.
- Overdose
- 1. This product can inhibit the metabolism of warfarin and other oral anticoagulants, strengthen their effect, and cause prolonged prothrombin time.
- 2. When combined with phenytoin sodium, phenobarbital, and other drugs that induce liver microsomal enzymes, it can accelerate the metabolism of the product, reduce the blood concentration, and slow the excretion of phenytoin sodium.
- 3 When combined with cimetidine and other drugs that inhibit liver microsomal enzyme activity, it can slow down the metabolism and excretion of the product in the liver, and prolong the blood elimination half-life of the product (t1 / 2 (), which should be based on the blood concentration The results of the measurement adjust the dose.
- 4 This product interferes with the metabolism of disulfiram. When the two are used together, the patient may have mental symptoms after drinking. Therefore, those who use disulfiram within 2 weeks should not use this product again.
- 5. This product can interfere with the determination of serum aminotransferase and lactate dehydrogenase, and can reduce cholesterol and triacylglycerol levels.
- 6. When combined with oxytetracycline, oxytetracycline can interfere with the effect of this product in removing trichomoniasis.
- preparation
- (1) 0.2g
- (2) 0.25g
- (3) 0.5g
Tinidazole manufacturer
- Zhejiang Keli Si'an Pharmaceutical Co., Ltd., Guangdong Pidi Pharmaceutical Co., Ltd., Hubei Sihuan Pharmaceutical Co., Ltd., Tianquan Biochemical Pharmaceutical Co., Ltd. in Longyan City, Fujian Province, Jiangsu Huanghe Pharmaceutical Co., Ltd., and Jiangsu Huanghai Pharmaceutical Co., Ltd. , Shaanxi Qindong Pharmaceutical Factory, Xi'an Tianyuan Pharmaceutical Co., Ltd., Sichuan United University Hualian Pharmaceutical Co., Ltd., Sichuan Bazhong Pharmaceutical Factory, Shantou Nanbei Pharmaceutical Factory Co., Ltd., Hainan Sanye Pharmaceutical Group Co., Ltd., Zhongda Luoma Pharmaceutical Co., Ltd. Responsible company, Guangzhou Qiaoguang Pharmaceutical Co., Ltd., Guangdong Qingfa Pharmaceutical Co., Ltd., Hunan Dinuo Pharmaceutical Co., Ltd., Hubei Guangji Pharmaceutical Co., Ltd., Shandong Luoxin Pharmaceutical Co., Ltd., Shandong Fangming Pharmaceutical Co., Ltd. Zhejiang Yulian Huali Si'an Pharmaceutical Company, Mudanjiang Wenchun Pharmaceutical Factory in Heilongjiang Province, Jiangsu Banqiao Pharmaceutical Co., Ltd., Dongtai Kangyi Pharmaceutical Co., Ltd., Xuzhou Enhua Pharmaceutical Group Fourth Pharmaceutical Factory, Shanghai Changzheng Fumin Pharmaceutical Industry Co., Ltd., Hangkang Marine Biological Pharmaceutical Co., Ltd., Suzhou Tonghua Pharmaceutical Co., Ltd., Jinzhou Jiutai Pharmaceutical Co., Ltd. Ltd., Jinzhou Jiutai Pharmaceutical Co., Ltd., Shijiazhuang Shineway Pharmaceutical Co., Ltd., Shijiazhuang No. 4 Pharmaceutical Co., Ltd.