What Is Tolnaftate?

Tolnaftate chemical name is N-methyl-N- (3-m-tolyl) thiocarbamate-2-naphthyl ester, white powder, molecular formula is C19H17NOS, molecular weight is 307.40900, density is 1.223 g / cm3 , Melting point is 110.5-111.5ºC, boiling point is 453.4ºC at 760 mmHg, flash point is 228ºC, refractive index is 1.697.

Chinese name: Tonamate
Foreign name: Tolnaftate
CAS number: 2398-96-1

Molecular formula: C19H17NOS
Molecular weight: 307.41
Density: 1.223 g / cm3

Introduction of tonaphthoate compounds

Tonaphthoate Basic Information

Chinese name: tonaphthyl ester

Chinese alias: N-methyl-N- (3-m-tolyl) thiocarbamate-2-naphthyl ester

English name: tolnaftate

English alias: Timoped; Tinactin; Tinavet; Dermoxin; sorgoa

CAS number: 2398-96-1

Molecular formula: C ₁₉ H ₁₇ NOS

Molecular weight: 307.40900

Structural formula:

Exact mass: 307.10300

PSA: 44.56000

LogP: 4.94830 ^[1]

Tonaphthate

Appearance and properties: white powder

Density: 1.223 g / cm ³

Melting point: 110.5-111.5ºC

Boiling point: 453.4ºC at 760 mmHg

Flash point: 228ºC

Refractive index: 1.697

Storage conditions: 2-8ºC

Vapor pressure: 2.08E-08mmHg at 25 ° C ^[1]

Tornamate

1. Hydrophobic parameter calculation reference value (XlogP): 5.5

2.Number of hydrogen bond donors: 0

3.Number of hydrogen bond acceptors: 2

4.Number of rotatable chemical bonds: 3

5.Number of tautomers: none

6.Topological molecular polar surface area: 44.6

7.Number of heavy atoms: 22

8.Surface charge: 0

9.Complexity: 386

10.Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Uncertain number of chemical bond stereocenters: 0 ^[2]

15.Number of covalent bond units: 1

Tonarate use

Topical antifungal. Used for superficial skin fungal infections, including ringworm, jock itch, tinea pedis, tinea versicolor, but not effective on fungal infections of the hair and nails. ^[1]

Tornaftate

Tonapate is an antifungal drug used to treat and prevent various types of superficial fungal infections, such as tinea capitis, tinea pedis, tinea corporis, and ringworm, especially tinea pedis. In the treatment of fungal infections, tonate esters have been used as OTC drugs for many years abroad, and their efficacy and safety have been fully confirmed. The incidence of skin fungal infections is high, and it is easy to recur. It is second only to dermatitis and eczema in dermatology cases, and there are relatively few clinical treatment drugs. the Lord. These drugs are generally expensive and irritating, while tonaphthoate is cheap and non-irritating, and the effect is exact. In this area, therapeutics are increasing at a rate of 15% per year. At present, the domestic antifungal external drug market capacity is 2.5 billion yuan, and the market potential is huge. There is no imitation product, and there are no patent and administrative protection issues.

Troponate pharmacological action

This product inhibits Epidermophyton, Microsporum, Trichophyton and Microspore rash (Sclerotinia sclerotiorum), but has no effect on Candida and bacteria. ^[3]

Tonarate

This product is a local antibacterial agent and can be used to treat various ringworm diseases such as ringworm, ringworm, and ringworm. When Candida infection, this product is combined with nystatin. Not suitable for deep infections of nail beds or hair sacs. ^[3]