What Are Islet Cell Antibodies?
Anti-islet cell antibodies are organ-specific antibodies. The antigen is an islet cytoplasmic component or a microsomal component, mainly of the lgG class, and is a marker of -cell damage in islet cells.
Anti-islet cell autoantibodies
Right!
- Chinese name
- Anti-islet cell autoantibodies
- Category
- Medical
- Attributes
- antibody
- About
- Islet cells
- Anti-islet cell antibodies are organ-specific antibodies. The antigen is an islet cytoplasmic component or a microsomal component, mainly of the lgG class, and is a marker of -cell damage in islet cells.
- Clinical significance of anti-islet cell antibody (ICA):
- (1) The diagnosis rate of insulin-dependent diabetes mellitus is 60% to 70% in patients with insulin-dependent diabetes mellitus. It can often be detected in the early stage of clinical onset and decreases after a few weeks. The detection rate is about 20 years after onset. %.
- (2) As a type of diabetes, the positive rate of IDDM patients at the time of onset is 65% to 85%, while the positive rate of NIDDM patients at the time of onset is about 10%.
- (3) To judge the outcome of non-insulin-dependent diabetes, and the clinical manifestations of patients with NIDDM, ICA still predicts the occurrence of IDDM and secondary indicators of failure of oral hypoglycemic agents.
- (4) As a monitoring indicator after islet gland transplantation, after allogeneic pancreas transplantation, patients with ICA in the blood of patients are prone to rejection of the graft.
- Note: The detection rate of ICA and GADA in patients with type 1 diabetes mellitus is positively correlated. The coincidence rate of the two antibodies is 90% in the early stage of disease and 54% in the course of the disease. [1]