What Does a Research Associate Do?

Tang Tieshan, male, Ph.D., researcher, doctoral supervisor; director of Molecular Neurobiology Research Group, Institute of Zoology, Chinese Academy of Sciences.

Tang Tieshan

(researcher)

In 2008, he was recruited into the "Hundred Talents Program-Introducing Outstanding Talents Abroad" from the Institute of Zoology, Chinese Academy of Sciences, and established the "Molecular Neurobiology Research Group" in the State Key Laboratory of Biofilm and Membrane Engineering. He obtained his Ph.D. in 1998 from the Open Laboratory of Molecular Development, Institute of Developmental Biology, Chinese Academy of Sciences. Post-doctoral research and lecturer at the Department of Physiology, Southwestern Medical Research Center, University of Texas, since 2000.

The main research direction is the functional regulation of calcium signals in nerve cells under physiological and pathological conditions.

Wang QC1, Zheng Q1, Tan H1, Zhang B1, Li X1, Yang Y, Yu J, Liu Y, Chai H, Wang X, Sun Z, Wang JQ, Zhu S, Wang F, Yang M, Guo C, Wang H , Zheng Q, Li Y #, Chen Q #, Zhou A *, Tang TS * (2016) TMCO1 is an ER Ca2 + load-activated Ca2 + (CLAC) channel.

Yi-Han Wang1, Jiu-Qiang Wang1, Qiaochu Wang1, Yun Wang, Caixia Guo, Quan Chen, Tuanyao Chai *, Tie-Shan Tang * (2016) Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy

Jinting Yan, Hui Zhang, Yang Liu, Feilong Zhao ,. Shu Zhu, Tie-Shan Tang *, and Caixia Guo * (2016) Germline Deletion of Huntingtin Causes Male Infertility and Arrested Spermiogenesis in Mice

Wang Z, Huang M, Ma X, Li H, Tang TS *,. Guo C * (2016) REV1 promotes PCNA monoubiquitination through interacting with ubiquitinated RAD18.

Yang Y #, Liu Z #, Wang F #, Temviriyanukul P, Ma X, Tu Y, Lv L, Lin YF, Huang M, Zhang T, Pei H, Chen BP, Jansen JG, de Wind N, Fischhaber PL, Friedberg EC , Tang TS *, Guo C * (2015) FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress.

Xiaoling Li, Hongmei Liu, Paula L. Fischhaber *, Tie-Shan Tang * (2015) Towards therapeutic targets for SCA3: insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance.

Qin Y, Guo T, Li G, Tang TS, Zhao S, Jiao X, Gong J, Gao F, Guo C, Simpson JL, Chen ZJ * (2015) CSB-PGBD3 Mutations Cause Premature Ovarian Failure. PLoS Genet.

Wenjuan Xie, Jiu-Qiang Wang, Qiao-Chu Wang, Yun Wang, Sheng Yao *, Tie-Shan Tang * (2015) Adult neural progenitor cells from Huntington's disease mouse brain exhibit increased proliferation and migration due to enhanced calcium and ROS signals.

Fengli Wang, Paula L. Fischhaber, Caixia Guo, Tie-Shan Tang * (2014) Epigenetic modifications as novel therapeutic targets for Huntington's disease.

Liu Y, Yang Y, Tang TS, Zhang H, Wang Z, Friedberg E, Yang W, Guo C *. (2014) Variants of mouse DNA polymerase reveal a mechanism of efficient and accurate translesion synthesis past a benzo [a] pyrene dG adduct.

Xiaoling Li, Fengqin Qu, Wenjuan Xie, Fengli Wang, Hongmei Liu, Shuhui Song, Tingting Chen, Yang Zhang, Shu Zhu, Yun Wang, Caixia Guo, Tie-Shan Tang * (2014) Transcriptomic analyses of neurotoxic effects in mouse brain after intermittent neonatal administration of thimerosal.

Lv L, Wang F, Ma X, Yang Y, Wang Z, Liu H, Li X, Liu Z, Zhang T, Huang M, Friedberg E, Tang TS, Guo C *. (2013) Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation.

Wang F, Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C *, Han C *, Tang TS *. (2013 ) Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease.

Xiuli Zhang #, Lingna Lv #, Qian Chen #, Fenghua Yuan, Ting Zhang, Yeran Yang, Hui Zhang, Yun Wang, Liangyue Qian, Benjamin Chen, Yanbin Zhang, Errol C Friedberg, Tie-Shan Tang *, Caixia Guo * ( 2013) Mouse DNA Polymerase Kappa Has A Functional Role in the Repair of DNA Strand Breaks.

Jiu-Qiang Wang, Qian Chen, Xianhua Wang, Qiao-Chu Wang, Yun Wang, He-Ping Cheng, Caixia Guo, Qinmiao Sun, Quan Chen, Tie-Shan Tang * (2013) Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington's Disease.

Zhifeng Wang #, Fengli Wang #, Tie-Shan Tang *, Caixia Guo * (2012) The role of PARP1 in the DNA damage response and its application in tumor therapy. Front Med.

Guo C, Tang TS, Friedberg EC. (2010) SnapShot: Nucleotide Excision Repair.

Hongyu Wang, Xi Chen, Yuemei Li, Tie-Shan Tang * and Ilya Bezprozvanny * (2010) Tetrabenazine is neuroprotective in Huntington's disease mice.

Guo C, Kosarek JN, Tang TS and Friedberg EC. (2009.

Tang, TS, Guo, C., Wang, H., Chen, X., Bezprozvanny, I. (2009) Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model. J Neuroscience.

* Highlighted in: The Journal of Neuroscience Feb 4; 29 (5): i. I.

Chen, X., Tang, TS, Tu, H., Nelson O., Pook, M., Hammer, R., Nukina, N., Bezprozvanny, I. (2008) Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3 .

Schneider, JW, Gao. Z., Li, S., Farooqi, M., Tang, TS, Bezprozvanny, I., Frantz, D., Hsieh, J. (2008) Small molecule activation of neuronal cell fate.

Guo, C., Tang, TS, Bienko, M., Dikic, I. and Friedberg EC (2008) Requirements for the Interaction of Mouse Pol With Ubiquitin, and its Biological Significance.

Tang, TS, Chen, X., Liu, J., Bezprozvanny, I. (2007) Dopaminergic signaling and apoptosis of medium spiny neurons in Huntington's disease. J.

Guo C, Sonoda E, Tang TS, Parker JL, Bielen AB, Takeda S, Ulrich HD, Friedberg EC. (2006) REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo.

Guo C, Tang TS, Bienko M, Sonoda E, Parker JL, Bielen AB, Takeda S, Ulrich HD, Dikic I, Friedberg EC. (2006) Ubiquitin-Binding Motifs in Rev1 Protein are Required for Its Role in the Tolerance of DNA Damage

Wu, J., Tang, TS, and Bezprozvanny, I. (2006) Evaluation of clinically-relevant glutamate pathway inhibitors in in vitro model of Huntington's disease.

Tang, TS, Slow, E., Lupu, V., Stavrovskaya, IG, Sugimori, M., Llinas, R., Kristal, BS, Hayden, MR, Bezprozvanny, I. (2005) Disturbed Ca2 + signaling and apoptosis of medium spiny neurons in Huntington's disease.

[This work has been reported or reprinted by Medical News Today, EurekAlert, Innovations Report, BETTERHUMANS, News-Medical in Medical Research News, Datamonitor NewsWire].

Ying Chen, Uwe Beffert, Mert Ertunc, Tie-Shan Tang, Ege T. Kavalali, Ilya Bezprozvanny, Joachim Herz (2005) Reelin modulates NMDA receptor activity in cortical neurons.

Tang, TS, Bezprozvanny, I. (2004) Dopamine receptor-mediated Ca2 + signaling in striatal medium spiny neurons.

Tu *, H., Tang *, TS, Wang, Z., Bezprozvanny, I. (2004) Association of type 1 inositol 1,4,5-trisphosphate receptor with AKAP9 (Yotiao) and protein kinase A

Tang, TS, Tu, H., Orban, PC, Chan, EY, Hayden, MR, Bezprozvanny, I. (2004) HAP1 facilitates effects of mutant huntingtin on inositol- (1,4,5) trisphosphate-induced Ca2 + release in striatal medium spiny neurons

Tang, TS, Tu, H., Chan, EY, Maximov, A., Wang, Z., Wellington, CL, Hayden, MR, Bezprozvanny, I. (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol- (1,4,5) trisphosphate receptor type 1.

a) Anurag Varshney and Barbara E. Ehrlich (2003) Intracellular Ca2 + Signaling and Human Disease: The Hunt Begins with Huntington's.

b) Colin Taylor, University of Cambridge, UK (2003) The Scientist.

c) Faculty of 1000 Biology: evaluations for Tang TS et al.

Tang *, TS, Tu *, H., Wang, Z., and Bezprozvanny, I. (2003) Modulation of the type 1 inositol (1,4,5) -trisphosphate receptor function by PKA and PP1-alpha.

Maximov *, A, Tang *, TS, Bezprozvanny, I. (2003) Association of the Inositol (1,4,5) -trisphosphate receptors with 4.1N protein in neurons.

Tang, TS, Dong, JB, Huang, XY and Sun, FZ (2000) Ca2 + oscillations induced by a cytosolic sperm protein factor are mediated by a maternal machinery which functions only once in mammalian eggs.

Dong, JB, Tang, TS and Sun, FZ (2000) Xenopus and chicken sperm contain a cytosolic soluble factor which can trigger calcium oscillations in mouse eggs.

Dong, Y., Tang, TS, Lu, CL, He, C., Dong, JB, Huang, XY, Sun, FZ, Bao, X. (2000) Pituitary adenylate cyclase activating polypeptide ameliorates the damage and inhibits the increase of intracellular calcium concentration in cultured hippocampal neurons induced by glutamate.

Guo, CX, Tang, TS, and Liu, YX (2000) Germ cell apoptosis and regulation in testis.

Guo, CX, Tang, TS, Mu, XM, Li, SH, Fu, GQ, Liu, H. and Liu, YX (1999) Cloning of novel temperature-related expressed sequence tags in rat testis during spermatogenesis

Deng, MQ, Huang, XY, Tang, TS and Sun, FZ (1998) Spontaneous and fertiliz. ation-induced Ca2 + oscillations in mouse immature germinal vesicle-stage oocytes.

Tang, TS and Dou, ZY (1993) Progress in establishment of embryonic stem (ES) cell lines from mammals. Acta Univ. Agric ^[1] .

The relationship between the intracellular calcium signal disorder of nerve cells and Huntington's neurodegenerative disease (chorea disease) was first discovered internationally; and gene therapy was used to stabilize the calcium signal of neurons in chorea model mice, significantly delaying it Disease Model Mouse Degenerative Lesion of Striatum Neurons. The research results obtained in recent years have been published in international core academic journals, including Neuron, PNAS, J Neuroscience, Development, J Biol Chem, etc. So far, he has published more than 25 SCI-indexed papers and obtained one US patent. Future research will focus on model animals such as mice, fruit flies, and zebrafish as a research system, and use molecular and cell biology, genetics, and biochemical technologies to explore neuronal calcium signal disorders, DNA damage repair, and neurodegenerative diseases. To explore the treatment of neurodegenerative diseases based on the nerve calcium signaling pathway, DNA damage and repair pathways as the entry point. Currently, as the project leader, he has undertaken the Chinese Academy of Sciences Hundred Talents Program, the Chinese Academy of Sciences Knowledge Innovation Project important direction project, and the National Natural Science Foundation of China ^[1] .

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