What Does an Animal Researcher Do?

Researcher of Institute of Zoology, Chinese Academy of Sciences, and leader of reproductive pathology research group.

Wang Yanling

(Researcher, Institute of Zoology, Chinese Academy of Sciences)

Graduated in 1993

Research on the cell and molecular mechanism of embryo implantation, pathogenesis of pregnancy-related diseases, early embryonic development regulation, etc. He presided over the National 973 Project, the National Natural Science Foundation of China's key projects, general projects, and important projects of the Knowledge Innovation Project of the Chinese Academy of Sciences. He has published more than 40 academic papers in domestic and foreign magazines since 1999, of which more than 30 have been included in SCI. In 2006, he won the second prize of the National Science and Technology Progress Award, and in 2005 he won the first prize of the Beijing Municipal Science and Technology Award.

His research focuses on the regulatory mechanism of placental development and the pathogenesis of major pregnancy diseases such as preeclampsia. We have established and stabilized various in vitro models that study the interaction between trophoblast cells and endometrium at the human maternal-fetal interface, and have established animal models of placental-specific gene manipulation through lentivirus and adenovirus infection; and established eclampsia through prospective analysis Pre-plasma and placenta specimen bank; screening and identification of plasma markers predicted early in preeclampsia. The established in vivo and in vitro research models are being used to explore the role of marker-related signaling pathways in early placental development, and to study the molecular associations of genetic and epigenetic abnormalities in key factors with preeclampsia. Our research goals are to explain the key regulatory aspects of human placental development, reveal the genetic and epigenetic basis of preeclampsia, and develop a comprehensive strategy for early diagnosis and intervention of preeclampsia.
He has published more than 30 academic papers in SCI journals such as Molecular Aspects of Medicine, Journal of Clinical Endocrinology and Metabolism, RNA Biology, PLoS ONE, Molecular Endocrinology, Human Reproduction, Biology of Reproduction . ^[2]

Wang Yanling Scientific Research Project

National Natural Science Foundation of China: Placental steroid hormone regulating body coagulation-fibrinolysis balance and pregnancy outcome mechanism, project leader, 750,000 yuan

Major project of National Natural Science Foundation of China: Molecular mechanism of maternal-fetal interactions to regulate recurrent miscarriage caused by disorders and preeclampsia and other pregnancy diseases, project leader, 18 million yuan

China-Canada Health Research Cooperation Program (NSFC-CIHR) project: mechanism study of microRNA as a target for pre-eclampsia diagnosis and treatment, project leader, 1 million yuan.

National Outstanding Youth Fund: Placental development and preeclampsia pathogenesis, 2 million yuan

National Major Scientific Research Program: Study on the molecular mechanism of pregnancy establishment and maintenance, the main research backbone, 2 million yuan

Important Directional Project of Knowledge Innovation Project of Chinese Academy of Sciences: Research on Molecular Markers and Diagnosis and Treatment Strategies of Important Pregnancy-related Diseases, Project Leader, RMB 6 million

NSFC-CIHR collaborative research project the role of microRNA in the occurrence of preeclampsia, project leader, 450,000 yuan ^[3]

On behalf of Wang Yanling

Luo R, Wang Y, Xu P, Cao G, Zhao Y, Shao X, Li YX, Chang C, Peng C, Wang YL *. Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A

Li S, Wang Y, Cao B, Wu Y, Ji L, Li YX, Liu M, Zhao Y, Qiao J, Wang H, Wang H, Han C, Wang YL * .Maturation of GDF15 in human placental trophoblast cells depends on the interaction with matrix metalloproteinase-26 (MMP-26)

Luo R, Shao X, Xu P, Liu Y, Wang Y, Zhao Y, Liu M, Ji L, Li YX, Chang C, Qiao J, Peng C *, Wang YL * MicroRNA-210 contributes to preeclampsia by down-regulating KCMF1

Xu P, Zhao Y, Liu M, Wang Y, Wang H, Li YX, Zhu X, Yao Y, Wang H, Qiao J, Ji L, Wang YL *. Variations of micrornas in human placentas and plasma from preeclamptic pregnancy

Burton GJ *, Sebire NJ, Myatt L, Tannetta D, Wang YL, Sadovsky Y, Staff AC, Redman CW (2014). Optimising sample collection for placental research

Ji L, Brki J, Liu M, Fu G, Peng C *, Wang YL *. Placental trophoblast cell differentiation: physiological regulation and pathological relevance to preeclampsia

Yu L, Li D, Liao Q, Yang H, Cao B, Fu G, Ye G, Bai Y, Wang H, Cui N, Liu M, Li YX, Peng C, Wang YL *. High levels of ActivinA detected in preeclamptic placenta induce trophoblast cell apoptosis by promoting Nodal signaling

Yang Y, Wang Y, Zeng X, Ma XJ, Zhao Y, Qiao J, Cao B, Li YX, Ji L, Wang YL *. Self-control of HGF regulation on human trophoblast cell invasion via enhancing c-Met receptor shedding by ADAM10 and ADAM17

Bai Y, Yang W, Yang H, Liao Q, Ye G, Fu G, Ji L, Xu P, Wang H, Li YX, Peng C, Wang YL *. Downregulated miR-195 detected in preeclamptic placenta affects trophoblast cell invasion via modulating ActRIIA expression

Gao WL, Liu M, Li D, Yang H, Liao Q, Yang Y, Bai Y, Li YX, Peng C, Wang YL *. The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1 (NOMO1)

Gao WL, Li D, Xiao Z, Liao QP, Yang HX, Li Y, Ji L, Wang YL *. Detection of global DNA methylation and paternally imprinted H19 gene methylation in preeclamptic placentas ^[3]

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