What Are the Common Venlafaxine Side Effects?

Main ingredients of this product: Venlafaxine hydrochloride Chemical name: (±) 1 [2 (dimethylamino) 1 (4methoxyphenyl) ethyl] cyclohexanol hydrochloride Molecular formula : C ₁₇ H ₂₇ NO ₂ HCl
Molecular weight: 313.87

Venlafaxine hydrochloride tablets are suitable for various types of depression, including depression with anxiety, and generalized anxiety.

Drug Name: Venlafaxine Hydrochloride Tablets
Hanyu Pinyin: Yan Suan Wen La Fa Xin Pian

Drug type: Occupational injury medical insurance
Use classification: Other antidepressants

Venlafaxine hydrochloride tablets ingredients

Indications of venlafaxine hydrochloride tablets

Suitable for all types of depression, including depression with anxiety, and generalized anxiety.

Dosage and Administration of Venlafaxine Hydrochloride Tablets

Orally, starting dose is 25mg once, 2-3 times a day. Depending on the condition gradually increased to 75mg-225mg a day, take 2-3 times. The maximum amount is 350 mg per day. Can be taken with food. Or as directed by your doctor.

Venlafaxine hydrochloride adverse reactions

Common loss of appetite, constipation, nausea, vomiting, dizziness, dry mouth, sedation, sweating (including night sweats), weakness / tiredness, high blood pressure, nervousness, yawning, abnormal sexual function, etc. When venlafaxine is suddenly discontinued, doses are reduced or gradually reduced, the following symptoms are reported: hypomania, anxiety, agitation, nervousness, confusion, insomnia or other sleep disturbances, fatigue, lethargy, paresthesia, headache Fainting, convulsions, dizziness, headache, tinnitus, sweating, dry mouth, anorexia, diarrhea, nausea or vomiting. The vast majority of discontinuations are mild and recover without treatment.

Venlafaxine hydrochloride taboo

1.Use with caution in patients with angle-closure glaucoma and epilepsy;
2.Use with caution in patients with severe heart disease, hypertension, thyroid disease, and blood disease;
3. Use with caution in patients with liver and kidney dysfunction;
4. Pregnant women and children should be used with caution.

Precautions for Venlafaxine Hydrochloride Tablets

1. Patients who use venlafaxine should closely observe clinical symptoms worsening and suicidal behavior, especially during treatment initiation or dose or dose regimen changes. The risk of possible suicide attempts must be considered, especially for patients with depression, the minimum starting amount of the drug should be used to reduce the risk of overdose;
2. Deterioration of clinical symptoms and suicidal risk: Adults and children with depression, whether or not they take antidepressants, their depression may worsen, and suicidal ideation and suicidal behavior and abnormal behavior changes may occur This risk continues until there is a noticeable remission.

Venlafaxine hydrochloride tablets for pregnant and lactating women

Use with caution in pregnant women.

Venlafaxine hydrochloride tablets for children

Children should be used with caution.

Venlafaxine Hydrochloride Tablets Drug Interactions

Combining this product with a monoamine oxidase inhibitor will cause serious and even fatal side effects. Patients using monoamine oxidase inhibitors need to stop taking the drug for 14 days before using this product, patients using this product need to stop using the drug for 7 days before using monoamine oxidase inhibitors. This product can reduce the clearance of venlafaxine when used in combination with cimetidine. This product has a weak inhibitory effect on the cytochrome P450D6 enzyme, so it may interact with other drugs metabolized by this enzyme.

Venlafaxine hydrochloride tablets overdose

The general treatment measures are similar to those of other antidepressant overdose, to ensure airway patency and proper oxygen and ventilation, monitor heart rate and vital signs, and use general support and symptomatic treatment. Emetic is not recommended, and gastric lavage can be performed for patients who have symptoms or have not taken medicine recently to keep the airway open during gastric lavage. Consider using activated carbon (which can limit drug absorption). Because the drug has a large distribution volume, strong diuresis, dialysis, hemoperfusion, and blood exchange therapy may not be effective. No special antidote is currently available. When dealing with drug overdose. Consideration should be given to the possibility of taking multiple drugs simultaneously. The doctor should contact the poison control center for further information.

Pharmacology and Toxicology of Venlafaxine Hydrochloride Tablets

Pharmacological effects Non-clinical studies have shown that venlafaxine and its active metabolite O-desmethylvenlafaxine are strong inhibitors of 5-HT and NE reuptake and weak inhibitors of dopamine. In vitro tests did not find that venlafaxine and O-desmethylvenlafaxine have significant affinity for M choline receptors, H1 histamine receptors, and 1-adrenergic receptors. Venlafaxine and O-desmethylvenlafaxine have no MAO inhibitory activity.

Toxicological studies Genotoxicity Venlafaxine and O-desmethylvenlafaxine Ames test, CHO / HGPRT mammalian cell positive gene mutation test results were negative. Venlafaxine BALB / c-3T3 mouse cell transformation test, CHO cell sister chromosome exchange test, rat micronucleus test results were all negative. O-desmethylvenlafaxine CHO chromosome aberration test result was negative, and rat micronucleus test result was positive.

Reproductive toxicity is calculated as mg / m2 (the same applies hereinafter). When the oral dose of male rats reaches twice the maximum recommended human dose, there is no effect on fertility. Rats and rabbits were administered orally during pregnancy and lactation, when the doses were 2.5 times and 4 times the maximum recommended daily dose, respectively. No abnormalities were observed, but rat pups lost weight, stillbirth increased, and breastfeeding The number of pups that died in the first 5 days increased. The cause of death of the animal is unknown, and the dose that has no effect on the death of the pups is 0.25 times the maximum recommended daily dose for humans.

Carcinogenic mice were orally given venlafaxine at a dose of up to 120 mg / kg / day (1.7 times the maximum human recommended dose) for 18 consecutive months, and rats were orally given a venlafaxine dose of up to 120 mg / kg / day (The blood concentration of venlafaxine in male and female rats is 1 and 6 times the human blood concentration at the maximum recommended human dose, respectively, but O-desmethylvenlafaxine levels are lower than humans) For 24 consecutive months, no increase in tumor incidence was seen.

Pharmacokinetics of Venlafaxine Hydrochloride Tablets

This product is fast and good for oral absorption. When administered in a single dose, only 12.6% enters the circulation. Food has no effect on the absorption of this product and its metabolites. The average t _1/2 is 4 hours, and the apparent volume of distribution is 6 L / kg. It is mainly metabolized in the liver. Most of the original drug and its metabolites are excreted by the kidneys. Impaired renal function reduces venlafaxine and its metabolites by approximately 55%, and the elimination half-life is significantly prolonged. Therefore, in patients with nephropathy with creatinine clearance <30ml / min, attention should be paid to the dose adjustment. Dosage reduction for those with impaired liver function