What Are the Dangers of Pesticide Exposure?

Pesticide pollutants refer to substances that have been contaminated with pesticides and can cause harm to humans through prolonged exposure. Long-term low-dose exposure to pesticides can cause potential chronic damage to human health. Such chronic damage includes the effects on the nerves, respiratory, reproductive system and skin after long-term exposure to pesticides, as well as damage to immune function. For example, the environmental endocrine disrupting organochlorine pesticides that have been banned from use have a large fat-solubility. They are bio-enriched into the human body through the food chain, and are difficult to metabolize and detoxify. Toxicity is also difficult to reduce, thereby harming the central nervous system and inducing liver enzyme changes. It is DDTs and BHCs that have carcinogenic potential and genetic toxicity, which cause fetal malformations and affect human lifespan and offspring health.

The assessment of pesticides' exposure to human health is based on comprehensive analysis of basic research, toxicological test results, and epidemiological surveys of the population, and a qualitative and quantitative comprehensive assessment of the potential ability of pesticides to harm human health in order to determine The probability, extent, and severity of damage that may occur. The assessment of pesticide exposure in humans needs to consider the dose, frequency, and duration of exposure to pesticides in the environment. These data are generally obtained through questionnaires. For example, the route of indoor pesticide exposure for the general population may come from the surrounding air, food, water, particulate matter and indoor dust, and enter the human body through inhalation and non-inhalation; in addition, the opportunities for different activities to produce different pollutants are also different. Therefore, in addition to In addition to assessing the source of exposure, the intensity of the exposure is also necessary. ^[1]

It has been reported in the literature that organochlorine, organophosphorus, pyrethroid and urethane pesticide exposures are related to chronic diseases of the population, such as cancer, diabetes, neurodegenerative disease (Parkinson's syndrome), muscular atrophy Lateral spinal cord (birth defect, reproductive toxicity, chronic respiratory diseases, asthma, chronic obstructive pneumonia, arteriosclerosis and coronary heart disease, etc.) In addition, many cases of long-term exposure to pesticides have caused a variety of organ and tissue effects, such as long-term The spraying personnel exposed to organic pesticides have irreversible damage to the ability of renal tubules to reabsorb phosphate. Those who have been exposed to pesticides throughout the year have significantly lower liver demethylation function than the control group; some Hawaiians use pyrethroids, dichlorvos In the households of pesticides such as diazepam and diazepam, some people are exposed to asthma and respiratory tract damage. Pesticides are exposed to genetic damage, endocrine interference, mitochondrial dysfunction, oxidative stress, endoplasmic reticulum compression, unfolded protein response, and ubiquitin proteasome system Mechanisms such as injury affect human health. ^[1]