What Are the Different Causes of Blood Clotting?

The process of changing blood from a flowing liquid state to an immobile jelly-like clot is blood coagulation. This is a process of limited hydrolysis of a series of proteins involved in coagulation factors.

Blood clotting

The process of changing blood from a flowing liquid state to an immobile jelly-like clot is blood coagulation. This is caused by

The substances in blood and tissues that are directly involved in clotting are collectively called

The blood of vertebrates can coagulate into a clot called so-called blood cake when bleeding. Regarding the mechanism of blood coagulation, led by the "Morawitz doctrine (1903)", many doctrines have been created, but in 1963, the International Hemocoagulation Factor Name Selection Committee published a diagram of human coagulation mechanism models, which has been widely accepted. The coagulation is divided into four steps.

The study of the coagulation mechanism has promoted the understanding of many bleeding diseases, such as the cause of hemophilia (patients with very slow coagulation process and even small injuries without bleeding), mainly due to the lack of clotting factor VIII in plasma. Another example is found that coagulation factors II, VII, IX, and X are all synthesized in the liver, and vitamin K is required to participate in their formation. Lack of vitamin K will cause bleeding tendency; the application of vitamin K can improve the symptoms of coagulopathy. In addition, in the laboratory or clinical work, different measures can be taken according to the needs of each link in the coagulation process to achieve the purpose of delaying coagulation or effective hemostasis. For example, to prevent bleeding after surgery, coagulation substances such as thrombin and fibrin can be applied to the surgical site. Warm gauze, cotton or gelatin sponge can be used to press the wound to stop bleeding.