What are the different diseases associated with plasma cells?

There are a number of diseases that can affect plasma cells, white blood cells that produce antibodies within the body's immune response. Amyloidosis is a disorder where the body produces abnormal antibody proteins, which then accumulate in one or many organs. Two other diseases, lonely plasmacytoma and multiple myeloma, occur when plasma cell production is excessive and other cells create tumors in the bone marrow. The condition known as monoclonal gamopathy of undetermined significance, or MGU, causes an increase in the protein produced by the plasma cells of the body. Some people can develop a rare cancer called Waldenstrom's macroglobulinemia, which is characterized by an overproduction of IgM antibodies.

Amyloidosis patients have plasma cells that produce abnormal proteins. These proteins then accumulate in organs such as liver, heart or kidneys. When they accumulate, the ability of the organs becomes prevented from functioning properly. Are the three -headed types of amyloidosis: primaryAmyloidosis, where plasma cells begin to violate a non -functional reason without a known reason, secondary amyloidosis, which is caused by another disease, and hereditary amyloidosis that occurs in patients with certain genetic abnormalities.

Some diseases cause tumors to form in the bone marrow where plasma cells are located. Tumors are the result of myeloma cells, unnecessary plasma cells that are formed when plasma production gets out of control. In some cases, only one tumor in one bone will form; This is known as lonely plasmacytoma. Other patients develop multiple myeloma, the type of cancer that occurs when myeloma cells are present and form tumors in more bones. In many cases, when the patient begins with lonely plasmhatoma, the disease later proceeds to multiple myeloma.

Another disease that can affect plasmaThe cells of monoclonal gammapathy of undetermined significance. Patients with MGU produce an abnormal amount of a certain type of protein, leading to elevated blood protein levels. However, these levels often remain stable and do not cause problems for patients with disorder. Treatment is often unnecessary and only monitoring the condition with blood tests is required.

Waldenstrom's macroglobulinemia is a rare cancer that results from increased production of antibodies by IgM plasma cells. These antibodies are relatively large, so a high number of them can cause blood intensification, which is known as hyperviscosity. This can lead to problems with circulation and nervous system problems.