What Are the Pros and Cons of Hepatitis A Immunization?

Hepatitis A vaccine is a vaccine used to prevent hepatitis A. It has become one of the main vaccines for children in China. It was listed as one of the expanded immunization vaccines in May 2008. Some provinces and cities have provided free hepatitis A vaccine.

Hepatitis A vaccine

Hepatitis A

The human immune response is divided into specific immunity and non-specific immunity. The foreign material that invades the human body is called an antigen. Each viral antigen is generally composed of a protein capsid. The capsid has an epitope that determines the specificity of the immune system. After the antigen is bound to the antibody, the antibody tries to digest the antigen and simultaneously produces Epitope-associated

Hepatitis A inactivated vaccine is

Those who are susceptible to hepatitis A virus, children over 1 year old, and adults should be vaccinated. Hepatitis A inactivated vaccine is suitable for children, medical workers, food industry practitioners, and people with occupational exposure to hepatitis A virus. The initial exemption time for children is one year old, and there is no age limit for adults. In cases of fever, acute disease, and chronic chronic disease, vaccination should be postponed. Booster immunization can be performed 3 years after vaccination.

Live vaccine: add 1.0 mL of sterilized injection water, use after completely dissolving and shaking. Outside of upper arm

There are two major types of hepatitis A vaccines: inactivated hepatitis A vaccine and live attenuated vaccines. Live attenuated vaccines are further divided into ordinary live attenuated vaccines and freeze-dried live attenuated vaccines according to the difference in storage time and requirements. Hepatitis A vaccine basically has domestic and imported options to choose from, and there is less difference in the effect of preventing disease in the human body.

For the injection of hepatitis A vaccine, the live attenuated hepatitis A vaccine only requires one shot. The inactivated hepatitis A vaccine needs to be vaccinated twice, with an interval of six months (6 months). For those who need to be vaccinated against hepatitis A, choosing any one can resist the attack of hepatitis A virus.

Hepatitis A vaccine is the most effective way to prevent hepatitis A. The vaccines used to prevent hepatitis A in the domestic market can be divided into two types: domestic live attenuated hepatitis A vaccines and imported hepatitis A purified inactivated vaccines. Domestic

China has become the largest demand and supply market for global vaccine products. After many years of development, the gap between the number of vaccine varieties in China and developed countries has been small, but there is still a certain gap in the production capacity, key production processes, and quality of some vaccines of certain vaccine varieties, especially the production capacity of many vaccine varieties in China It is seriously inadequate, and production technology needs to be improved urgently. China is increasing investment in scientific research in related fields and striving to become a strong country in vaccine research and development and production.

In the next few years, the vaccine industry will become the core area for the development of the world pharmaceutical industry. In the domestic market, due to the steady increase in demand, the strengthening of the public's concept of immunization, and the government's policy guidance and support, the vaccine market will also develop and grow at a high speed in a good soil.

Many people in daily life think that preventing hepatitis A can prevent hepatitis A as long as you pay more attention to dietary hygiene. There is no need to get hepatitis A vaccine. Zhengzhou Zhongda Liver Disease Hospital experts clearly stated that in fact, paying attention to diet hygiene can prevent hepatitis A, but not to prevent the spread of hepatitis A. In addition to diet, other blood and fecal bacteria may infect hepatitis A. Therefore, injection of hepatitis A vaccine is necessary.

1. Hepatitis A is more serious. After the hepatitis A virus invades the human body, it can be replicated in the liver in a short period of time, which causes liver cell damage and causes many symptoms such as fever, anorexia, and diarrhea. Therefore, everyone should go to a regular medical institution as soon as possible. Hepatitis A vaccine.

2. Hepatitis A has a greater impact on the fetus. Infection in early pregnancy can cause miscarriage. Infection in late pregnancy can cause premature delivery, major bleeding, and severe cases can cause fetal death. Therefore, it is necessary to inject hepatitis A vaccine.

3. The transmission route of hepatitis A virus is mainly fecal-oral transmission, that is to say, hepatitis A is mainly transmitted through the digestive tract, and the spread is wide, which can easily cause an outbreak of infection in collective units. Therefore, experts from Zhengzhou Zhongda Liver Hospital recommend that in order to prevent infection Everyone should be vaccinated against Hepatitis A in a timely manner, especially children in kindergartens and schools, and people living in remote mountainous areas with poor sanitation. They should also be vaccinated against Hepatitis A in a timely manner for prevention.

4. Hepatitis A virus is highly contagious and viable. Investigation and research show that in the general environment contaminated by the source of infection, hepatitis A virus can survive for one month and aquatic shellfish for about three months. Therefore, for people with poor immunity, especially children, the hepatitis A vaccine should be injected in time to effectively prevent hepatitis A.

After a few shots, local pain, redness and swelling may occur. Systemic reactions include headache, fatigue, fever, nausea, and decreased appetite. It usually resolves itself within 72 hours. Occasionally, a rash does not require special treatment and can be treated symptomatically if necessary.

Data on adverse events were obtained from clinical studies prior to approved use. No serious adverse events have been identified for the hepatitis A vaccine. In adults, the most frequently reported side effects within three days after a dose of 1440 el.u were (cdc, 1996): pain at the injection site (56%), headache (14%), and discomfort (7%). In clinical studies in children, the most frequently reported side effects were pain at the injection site (15%), feeding problems (8%), headache (4%), and induration at the injection site (4%). Balcarek et al. (1995) found that 29.8% of preschool children receiving 360el.u.

What vaccine manufacturers get after approving use

Fever after a vaccination is normal. Because the vaccine itself is a virus that reduces activity, certain side effects are bound to occur after vaccination. To let your baby drink more water and rest, you can also use thin raw potato chips on

Store and transport in a dark place below 8 ° C, valid for 1 year and 6 months. Use within the validity period indicated on the box or bottle label.

The in-depth research on HAV immunobiology and molecular biology provides a new way for the development of hepatitis A vaccine. Hepatitis A vaccines currently under study include

After being vaccinated with hepatitis A vaccine, the body will produce hepatitis A antibodies. This kind of antibody will neutralize the ability of hepatitis A virus infection, which will prevent the body from getting sick and obtain lasting immunity. During the epidemic period, contacts with hepatitis A patients should be injected with the hepatitis A vaccine. It is best to go to a specialist hospital to ask a doctor to check whether there are contraindications for the injection of the hepatitis A vaccine or whether the situation is inappropriate:

1. Patients recovering from viral hepatitis and acute infectious diseases.

2. People with fever or severe heart disease, kidney disease, active tuberculosis, and severe hypertension.

3. Patients with immunodeficiency and immunosuppressive agents such as adrenocortical hormone.

4, pregnant women or those with allergies.

5. Domestic fever caused by domestic hepatitis A vaccine 37.5 degrees.

6. Those who are allergic to imported hepatitis A vaccine. ^[1]

Live vaccine vaccinates humans with attenuated hepatitis A virus strain (H2 strain)

Live vaccine: 1.0ml per vial after reconstitution, 1.0ml per human dose, the amount of live virus should not be less than 6.5LgCCID50; inactivated vaccine: 360 ELISA ux 1

The human body is well tolerant of the hepatitis A vaccine, and most people do not have any adverse reactions to the hepatitis A vaccine after vaccination. A small number of people may have mild redness or pain at the vaccination site. The adverse reactions of the hepatitis A vaccine generally subsided within 24-72 hours, which is a normal adverse reaction of the hepatitis A vaccine. Very few people may develop symptoms such as fatigue, fever, anorexia, diarrhea, nausea, and allergic rash of vomiting. The adverse reactions of this hepatitis A vaccine are usually transient, and most of them can resolve on their own within 24 hours.

Generally speaking, mild adverse reactions can occur without special treatment, and can heal by themselves. When the local reaction is severe, it can be applied locally after 72 hours, several times a day for 10-15 minutes each time. For serious adverse reactions of hepatitis A vaccine, symptomatic treatment can be taken if necessary. For first-time vaccination, you should stay on site for half an hour after injection to prevent rapid allergic reactions. If you have any abnormal reaction or delayed allergic reaction within 72 hours after returning home, you should go to the hospital for treatment as soon as possible to avoid delays opportunity.